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    N-Arylsulfonylpyrroles, their preparation, and therapeutic agents containing these compounds
    3.
    发明授权
    N-Arylsulfonylpyrroles, their preparation, and therapeutic agents containing these compounds 失效
    N-芳基磺酰吡咯，它们的制备和含有这些化合物的治疗剂

    公开(公告)号：US4288449A

    公开(公告)日：1981-09-08

    申请号：US154036

    申请日：1980-05-28

    申请人： Jens-Uwe Bliesener ,  Karl-Heinz Geiss ,  Dieter Lenke ,  Claus D. Mueller

    发明人： Jens-Uwe Bliesener ,  Karl-Heinz Geiss ,  Dieter Lenke ,  Claus D. Mueller

    IPC分类号： C07D207/48 ,  C07D307/68 ,  C07D333/28 ,  C07D333/38 ,  A61K31/40

    CPC分类号： C07D333/28 ,  C07D207/48 ,  C07D307/68 ,  C07D333/38

    摘要： Compounds of the formula 1 ##STR1## where R.sup.1 is a saturated, unsubstituted or substituted aliphatic radical of 1 to 8 carbon atoms, an unsaturated alkyl radical of 2 to 8 carbon atoms, a cycloalkyl radical of 3 to 7 carbon atoms in the ring or an alkyl radical of 1 to 4 carbon atoms which is substituted by phenyl or by a 5- or 6-membered aromatic heterocyclic ring containing an N, O or S atom, the phenyl ring or the heterocyclic ring itself being unsubstituted, monosubstituted or polysubstituted, andR.sup.2 is hydrogen orR.sup.1 and R.sup.2 together with the nitrogen are a 4-membered to 6-membered cycloaliphatic saturated heterocyclic ring,R.sup.3 is hydrogen or alkyl of 1 to 5 carbon atoms,R.sup.4 and R.sup.5 are identical or different and each is hydrogen or alkyl of 1 to 5 carbon atoms,X is oxygen, sulfur or >SO- or >NH- andAr is unsubstituted, monosubstituted, disubstituted or trisubstituted phenyl,and their therapeutically useful ammonium salts, alkali metal salts or acid addition salts, which compounds and salts thereof exhibit valuable pharmacological properties, their preparation, therapeutic agents containing these products, and their use as drugs.

    摘要翻译： 式1的化合物其中R1是1至8个碳原子的饱和，未取代或取代的脂族基团，2至8个碳原子的不饱和烷基，环中3至7个碳原子的环烷基，或 由苯基或含有N，O或S原子的5-或6-元芳族杂环取代的具有1至4个碳原子的烷基，苯环或杂环本身未被取代，单取代或多取代， 并且R 2是氢或R 1和R 2与氮一起是4元至6元环脂族饱和杂环，R 3是氢或1至5个碳原子的烷基，R 4和R 5是相同或不同的，各自是氢或 1至5个碳原子的烷基，X是氧，硫或> SO-或> NH-，Ar是未取代的，单取代的，二取代的或三取代的苯基及其治疗上有用的铵盐，碱金属盐或酸加成盐， 其盐显示出有价值的药理学性质，其制备方法，含有这些产品的治疗剂及其作为药物的用途。