公开(公告)号：US07112265B1

公开(公告)日：2006-09-26

申请号：US09869887

申请日：2000-01-11

申请人： Jerome F. McAleer ,  Manuel Alvarez-Icaza ,  Geoff Hall ,  Elliot V. Plotkin ,  David Scott ,  Oliver W. H. Davies

发明人： Jerome F. McAleer ,  Manuel Alvarez-Icaza ,  Geoff Hall ,  Elliot V. Plotkin ,  David Scott ,  Oliver W. H. Davies

IPC分类号： G01N27/327

CPC分类号： C12Q1/006 ,  G01N27/3272

摘要： An improved disposable glucose test strip for use in a test meter of the type which receives a disposable test strip and a sample of blood from a patient and performs an electrochemical analysis using a non-conductive integrated reagent/blood separation layer (17) containing a filler, an enzyme effective to oxidize glucose, e.g., glucose oxidase, and a mediator effective to transfer electrons from the enzyme. The integrated layer formulation is printed over a conductive carbon element (16) to form a working electrode. The filler, for example a silica filler, is selected to have a balance of hydrophobicity such that on drying it forms a two-dimensional network on the surface of the conductive element. The response of this test strip is essentially temperature independent over relevant temperature ranges and is substantially insensitive to the hematocrit of the patient.

摘要翻译： 一种改进的一次性葡萄糖测试条，用于接收来自患者的一次性测试条和血液样本的测试计，并使用非导电的集成试剂/血液分离层（17）进行电化学分析， 填充剂，有效氧化葡萄糖的酶，例如葡萄糖氧化酶和有效从酶转移电子的介质。 集成层制剂印在导电碳元件（16）上以形成工作电极。 选择填料，例如二氧化硅填料以具有疏水性的平衡，使得在干燥时，其在导电元件的表面上形成二维网络。 该测试条的响应在相关温度范围内基本上是温度独立的，并且对患者的血细胞比容基本上不敏感。

公开(公告)号：US07807031B2

公开(公告)日：2010-10-05

申请号：US11453174

申请日：2006-06-13

申请人： Jerome F. McAleer ,  Manuel Alvarez-Icaza ,  Geoff Hall ,  Elliot V. Plotkin ,  David Scott ,  Oliver W. H. Davies

发明人： Jerome F. McAleer ,  Manuel Alvarez-Icaza ,  Geoff Hall ,  Elliot V. Plotkin ,  David Scott ,  Oliver W. H. Davies

IPC分类号： G01N27/327

CPC分类号： C12Q1/006 ,  G01N27/3272

摘要： An improved disposable glucose test strip for use in a test meter of the type which receives a disposable test strip and a sample of blood from a patient and performs an electrochemical analysis is made using a non-conductive integrated reagent/blood separation layer containing a filler, an enzyme effective to oxidize glucose, e.g., glucose oxidase, and a mediator effective to transfer electrons from the enzyme. The integrated layer formulation is printed over a conductive carbon element to form a working electrode. The filler, for example a silica filler, is selected to have a balance of hydrophobicity and hydrophilicity such that one drying it forms a two-dimensional network on the surface of the conductive element. The response of this test strip is essentially temperature independent over relevant temperature ranges and is substantially insensitive to the hematocrit of the patient.

摘要翻译： 一种改进的一次性葡萄糖测试条，用于接收来自患者的一次性测试条和血液样本并进行电化学分析的测试计，其使用含有填料的非导电整合试剂/血液分离层 ，有效氧化葡萄糖的酶，例如葡萄糖氧化酶和有效从酶转移电子的介质。 将集成层制剂印刷在导电碳元件上以形成工作电极。 选择填充剂，例如二氧化硅填料，以具有疏水性和亲水性的平衡，使得其一次干燥在导电元件的表面上形成二维网络。 该测试条的响应在相关温度范围内基本上是温度独立的，并且对患者的血细胞比容基本上不敏感。

公开(公告)号：US06241862B1

公开(公告)日：2001-06-05

申请号：US09228855

申请日：1999-01-12

申请人： Jerome F. McAleer ,  Manuel Alvarez-Icaza ,  Geoff Hall ,  Elliot V. Plotkin ,  David Scott ,  Oliver W. H. Davies

发明人： Jerome F. McAleer ,  Manuel Alvarez-Icaza ,  Geoff Hall ,  Elliot V. Plotkin ,  David Scott ,  Oliver W. H. Davies

IPC分类号： G01N2726

CPC分类号： C12Q1/002 ,  C12Q1/004 ,  C12Q1/006 ,  C12Q1/54 ,  G01N27/3272 ,  G01N33/5002

摘要： An improved disposable glucose test strip for use in a test meter of the type which receives a disposable test strip and a sample of blood from a patient and performs an electrochemical analysis is made using a non-conductive integrated reagent/blood separation layer containing a filler, an enzyme effective to oxidize glucose, e.g., glucose oxidase, and a mediator effective to transfer electrons from the enzyme. The integrated layer formulation is printed over a conductive carbon element to form a working electrode. The filler, for example a silica filler, is selected to have a balance of hydrophobicity and hydrophilicity such that one drying it forms a two-dimensional network on the surface of the conductive element. The response of this test strip is essentially temperature independent over relevant temperature ranges and is substantially insensitive to the hematocrit of the patient.

摘要翻译： 一种改进的一次性葡萄糖测试条，用于接收来自患者的一次性测试条和血液样本并进行电化学分析的测试计，其使用含有填料的非导电整合试剂/血液分离层 ，有效氧化葡萄糖的酶，例如葡萄糖氧化酶和有效从酶转移电子的介质。 将集成层制剂印刷在导电碳元件上以形成工作电极。 选择填充剂，例如二氧化硅填料，以具有疏水性和亲水性的平衡，使得其一次干燥在导电元件的表面上形成二维网络。 该测试条的响应在相关温度范围内基本上是温度独立的，并且对患者的血细胞比容基本上不敏感。

公开(公告)号：US06733655B1

公开(公告)日：2004-05-11

申请号：US09521163

申请日：2000-03-08

申请人： Oliver W. H. Davies ,  Christopher P. Leach ,  Manuel Alvarez-Icaza

发明人： Oliver W. H. Davies ,  Christopher P. Leach ,  Manuel Alvarez-Icaza

IPC分类号： G01N2728

CPC分类号： C12Q1/001 ,  C12Q1/006 ,  G01N27/3272 ,  G01N33/5438

摘要： In a method of measuring the concentration of a substance such as glucose in a sample liquid such as blood or interstitial fluid, a measuring device is provided having a working sensor part (6b), a second working sensor part (8b) and a reference sensor part (4b). The sample liquid is applied to the measuring device and an electric current proportional to the concentration of the substance in the sample liquid is measured at each sensor part (6b, 8b). The electric currents are compared to establish the difference. If the difference is greater than a predetermined threshold, an error indication is given. A disposable test strip with two working sensors (6b, 8b) is also disclosed.

摘要翻译： 在测量诸如血液或间质液的样品液体中的诸如葡萄糖的物质的浓度的方法中，提供了具有工作传感器部分（6b），第二工作传感器部分（8b）和参考传感器 部分（4b）。 将样品液体施加到测量装置，并且在每个传感器部分（6b，8b）处测量与样品液体中物质浓度成比例的电流。 比较电流以确定差异。 如果差大于预定阈值，则给出错误指示。 还公开了具有两个工作传感器（6b，8b）的一次性测试条。

公开(公告)号：US07250105B1

公开(公告)日：2007-07-31

申请号：US10431140

申请日：2003-05-07

申请人： Oliver W. H. Davies ,  Christopher P. Leach ,  Manuel Alvarez-Icaza

发明人： Oliver W. H. Davies ,  Christopher P. Leach ,  Manuel Alvarez-Icaza

IPC分类号： G01N27/327 ,  G01N27/333

CPC分类号： C12Q1/001 ,  C12Q1/006 ,  G01N27/3272 ,  G01N33/5438

摘要： In accordance with the present invention a measuring device compares the current generated by two working sensor parts and gives an error indication if they are too dissimilar, i.e., the current at one sensor part differs too greatly from what would be expected from considering the current at the other. Not only can this method detect when one of the sensor parts has not been properly covered with sample liquid, but it can also detect if there is a manufacturing defect in either sensor part or if either has been damaged after manufacture, since even with complete coverage of the working sensor parts, an anomalous current will be generated at the affected sensor part under such circumstances.

摘要翻译： 根据本发明，测量装置比较两个工作传感器部件产生的电流，并给出错误指示，如果它们太不相似，即，一个传感器部分处的电流与考虑到 另一个。 当传感器部件之一没有被样品液体适当地覆盖时，该方法不仅可以检测，而且还可以检测传感器部件是否存在制造缺陷，或者在制造后是否已经损坏，因为即使完全覆盖 的工作传感器部件，在这种情况下，在受影响的传感器部件将产生异常电流。