PARTITIONING SYSTEMS AND METHODS FOR DETERMINING MULTIPLE TYPES OF CANCERS

    公开(公告)号:US20240011995A1

    公开(公告)日:2024-01-11

    申请号:US18469458

    申请日:2023-09-18

    申请人: Analiza, Inc.

    IPC分类号: G01N33/574 G01N33/50

    CPC分类号: G01N33/57488 G01N33/5002

    摘要: The present disclosure generally relates to systems and methods for partitioning species. In some embodiments, such systems can be used for determining one or more types of cancer. For example, certain aspects are generally directed to aqueous multi-phase partitioning systems that can be used, for example, for distinguishing between different types of cancers, diagnosing subjects with cancer, or the like. In some cases, such systems can be identified using solvent properties such as the solvent dipolarity/polarizability difference (Δπ*), the solvent hydrogen bond donor acidity difference (Δα), the solvent hydrogen bond acceptor basicity difference (Δβ), and the electrostatic property difference (c) between two phases of the partitioning system. These may be within certain ranges in accordance with various embodiments. Additionally, these ranges can be precisely tuned by controlling the compositions of the phases of the partitioning system to produce novel partitioning systems that are unexpectedly efficient at distinguishing between even relatively minor structural changes of proteins or other species, which accordingly can be used to distinguishing different types of cancers, or for other applications.

    SAMPLE IMAGE CAPTURING SYSTEM AND METHOD, AND COMPUTERREADABLE STORAGE MEDIUM

    公开(公告)号:US20240004181A1

    公开(公告)日:2024-01-04

    申请号:US18367428

    申请日:2023-09-12

    发明人: Bin JIANG

    摘要: The disclosure relates to a sample image capturing system, including: a sample holding apparatus configured to hold a sample slide on which a sample film is applied; an imaging apparatus configured to capture the sample on the sample slide; a sample appearance image obtaining apparatus configured to obtain a sample appearance image, where the sample appearance image includes at least an appearance image of the sample film; and a controller configured to: obtain the sample appearance image, identify an appearance characteristic of the sample film based on the sample appearance image, determine a capturing parameter based on the appearance characteristic, and control the imaging apparatus to capture, with the capturing parameter, sample components on the sample slide. The disclosure further relates to a sample image capturing method and a computer-readable storage medium. The disclosure can use a characteristic of the appearance image to achieve accurate capturing of sample images.

    Partitioning systems and methods for determining multiple types of cancers

    公开(公告)号:US11796544B1

    公开(公告)日:2023-10-24

    申请号:US18030849

    申请日:2022-10-13

    申请人: Analiza, Inc.

    IPC分类号: G01N33/574 G01N33/50

    CPC分类号: G01N33/57488 G01N33/5002

    摘要: The present disclosure generally relates to systems and methods for partitioning species. In some embodiments, such systems can be used for determining one or more types of cancer. For example, certain aspects are generally directed to aqueous multiphase partitioning systems that can be used, for example, for distinguishing between different types of cancers, diagnosing subjects with cancer, or the like. In some cases, such systems can be identified using solvent properties such as the solvent dipolarity/polarizability difference (Δπ*), the solvent hydrogen bond donor acidity difference (Δα), the solvent hydrogen bond acceptor basicity difference (Δβ), and the electrostatic property difference (c) between two phases of the partitioning system. These may be within certain ranges in accordance with various embodiments. Additionally, these ranges can be precisely tuned by controlling the compositions of the phases of the partitioning system to produce novel partitioning systems that are unexpectedly efficient at distinguishing between even relatively minor structural changes of proteins or other species, which accordingly can be used to distinguishing different types of cancers, or for other applications.