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公开(公告)号：US09732137B2
公开(公告)日：2017-08-15
申请号：US12810934
申请日：2008-12-22
申请人： Jesper Færgeman Lau , Asser Sloth Andersen , Paw Bloch , Jesper Lau , Patrick William Garibay , Thomas Kruse , Inga Sig Nielsen Nørby , Claus Ulrich Jessen , Caspar Christensen , Jens Christian Norrild
发明人： Jesper Færgeman Lau , Asser Sloth Andersen , Paw Bloch , Jesper Lau , Patrick William Garibay , Thomas Kruse , Inga Sig Nielsen Nørby , Claus Ulrich Jessen , Caspar Christensen , Jens Christian Norrild
CPC分类号： C07K14/605 , C07K1/006 , C07K1/02 , C07K1/061 , C07K1/107 , C07K1/1077
摘要： A semi-recombinant method for the production of GLP-1 analogues and derivatives with non-proteogenic amino acids in the N-terminal part combining the use of recombinant expression techniques and chemical peptide synthesis.
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公开(公告)号：US20100317057A1
公开(公告)日：2010-12-16
申请号：US12810934
申请日：2007-12-22
申请人： Jesper Faergeman Lau , Asser Sloth Andersen , Paw Bloch , Jesper Lau , Patrick William Garibay , Thomas Kruse , Inga Sig Nielsen Nørby , Claus Ulrich Jessen , Caspar Christensen , Jens Christian Norrild
发明人： Jesper Faergeman Lau , Asser Sloth Andersen , Paw Bloch , Jesper Lau , Patrick William Garibay , Thomas Kruse , Inga Sig Nielsen Nørby , Claus Ulrich Jessen , Caspar Christensen , Jens Christian Norrild
IPC分类号： C12P21/00
CPC分类号： C07K14/605 , C07K1/006 , C07K1/02 , C07K1/061 , C07K1/107 , C07K1/1077
摘要： A semi-recombinant method for the production of GLP-1 analogues and derivatives with non-proteogenic amino acids in the N-terminal part combining the use of recombinant expression techniques and chemical peptide synthesis.
摘要翻译： 在重组表达技术和化学肽合成的N末端部分中用于生产具有非蛋白质氨基酸的GLP-1类似物和衍生物的半重组方法。
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公开(公告)号：US20110111519A1
公开(公告)日：2011-05-12
申请号：US12929251
申请日：2011-01-11
IPC分类号： G01N21/75 , C07D207/46 , C07D401/12
CPC分类号： G01N21/6428 , C07C309/14 , C07D207/404 , C07D401/12 , C09B11/10 , G01N33/533 , G01N33/542 , G01N33/582
摘要： A reagent for use in detecting an analyte comprises a fluorescent energy donor and an energy acceptor, wherein the energy acceptor is of the general formula: and wherein the distance between the energy donor and the energy acceptor of the reagent is capable of modulation by a suitable analyte to be detected.
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公开(公告)号：US20130012432A1
公开(公告)日：2013-01-10
申请号：US13580042
申请日：2011-02-28
申请人： Kilian Waldemar Conde-Frieboes , Jane Spetzler , Ulrich Sensfuss , Birgitte Schjellerup Wulff , Henning Thoegersen , Jens Christian Norrild
发明人： Kilian Waldemar Conde-Frieboes , Jane Spetzler , Ulrich Sensfuss , Birgitte Schjellerup Wulff , Henning Thoegersen , Jens Christian Norrild
IPC分类号： A61K38/12 , A61P3/10 , A61P3/04 , A61P3/00 , A61P35/00 , A61P15/00 , A61P9/12 , A61P1/16 , A61P19/08 , A61P19/02 , A61P29/00 , A61P37/06 , C07K7/56 , A61P9/00
CPC分类号： C07K14/68
摘要： The present invention relates to novel peptide compounds which are effective in modulating one or more melanocortin receptor types, to the use of the compounds in therapy, to methods of treatment comprising administration of the compounds to patients in need thereof, and to the use of the compounds in the manufacture of medicaments. The compounds of the invention are of particular interest in relation to the treatment of obesity as well as a variety of diseases or conditions associated with obesity.
摘要翻译： 本发明涉及有效调节一种或多种黑皮质素受体类型的新型肽化合物，治疗中化合物的用途，包括向有需要的患者施用化合物的治疗方法，以及使用 药物制造中的化合物。 本发明的化合物在治疗肥胖以及与肥胖相关的各种疾病或病症方面特别有意义。
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公开(公告)号：US08318443B2
公开(公告)日：2012-11-27
申请号：US12929251
申请日：2011-01-11
CPC分类号： G01N21/6428 , C07C309/14 , C07D207/404 , C07D401/12 , C09B11/10 , G01N33/533 , G01N33/542 , G01N33/582
摘要： A reagent for use in detecting an analyte comprises a fluorescent energy donor and an energy acceptor, wherein the energy acceptor is of the general formula: and wherein the distance between the energy donor and the energy acceptor of the reagent is capable of modulation by a suitable analyte to be detected.
摘要翻译： 用于检测分析物的试剂包括荧光能量供体和能量受体，其中能量受体具有以下通式：并且其中能量给体和试剂的能量受体之间的距离能够通过合适的 待检测的分析物。
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公开(公告)号：US07892748B2
公开(公告)日：2011-02-22
申请号：US10582794
申请日：2004-12-14
CPC分类号： G01N21/6428 , C07C309/14 , C07D207/404 , C07D401/12 , C09B11/10 , G01N33/533 , G01N33/542 , G01N33/582
摘要： A reagent for use in detecting an analyte comprises a fluorescent energy donor and an energy acceptor, wherein the energy acceptor is of the general formula: and wherein the distance between the energy donor and the energy acceptor of the reagent is capable of modulation by a suitable analyte to be detected.
摘要翻译： 用于检测分析物的试剂包括荧光能量供体和能量受体，其中能量受体具有以下通式：并且其中能量给体和试剂的能量受体之间的距离能够通过合适的 待检测的分析物。
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