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公开(公告)号:US20100317057A1
公开(公告)日:2010-12-16
申请号:US12810934
申请日:2007-12-22
申请人: Jesper Faergeman Lau , Asser Sloth Andersen , Paw Bloch , Jesper Lau , Patrick William Garibay , Thomas Kruse , Inga Sig Nielsen Nørby , Claus Ulrich Jessen , Caspar Christensen , Jens Christian Norrild
发明人: Jesper Faergeman Lau , Asser Sloth Andersen , Paw Bloch , Jesper Lau , Patrick William Garibay , Thomas Kruse , Inga Sig Nielsen Nørby , Claus Ulrich Jessen , Caspar Christensen , Jens Christian Norrild
IPC分类号: C12P21/00
CPC分类号: C07K14/605 , C07K1/006 , C07K1/02 , C07K1/061 , C07K1/107 , C07K1/1077
摘要: A semi-recombinant method for the production of GLP-1 analogues and derivatives with non-proteogenic amino acids in the N-terminal part combining the use of recombinant expression techniques and chemical peptide synthesis.
摘要翻译: 在重组表达技术和化学肽合成的N末端部分中用于生产具有非蛋白质氨基酸的GLP-1类似物和衍生物的半重组方法。
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公开(公告)号:US07662935B2
公开(公告)日:2010-02-16
申请号:US12471884
申请日:2009-05-26
IPC分类号: A23J1/00
摘要: The invention provides novel methionine aminopeptidase enzymes and their use.
摘要翻译: 本发明提供新型甲硫氨酸氨基肽酶及其应用。
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公开(公告)号:US08530217B2
公开(公告)日:2013-09-10
申请号:US12639362
申请日:2009-12-16
IPC分类号: C12N9/52
摘要: The invention provides novel methionine aminopeptidase enzymes and their use.
摘要翻译: 本发明提供新型甲硫氨酸氨基肽酶及其应用。
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公开(公告)号:US20100099142A1
公开(公告)日:2010-04-22
申请号:US12639362
申请日:2009-12-16
摘要: The invention provides novel methionine aminopeptidase enzymes and their use.
摘要翻译: 本发明提供新型甲硫氨酸氨基肽酶及其应用。
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公开(公告)号:US09732137B2
公开(公告)日:2017-08-15
申请号:US12810934
申请日:2008-12-22
申请人: Jesper Færgeman Lau , Asser Sloth Andersen , Paw Bloch , Jesper Lau , Patrick William Garibay , Thomas Kruse , Inga Sig Nielsen Nørby , Claus Ulrich Jessen , Caspar Christensen , Jens Christian Norrild
发明人: Jesper Færgeman Lau , Asser Sloth Andersen , Paw Bloch , Jesper Lau , Patrick William Garibay , Thomas Kruse , Inga Sig Nielsen Nørby , Claus Ulrich Jessen , Caspar Christensen , Jens Christian Norrild
CPC分类号: C07K14/605 , C07K1/006 , C07K1/02 , C07K1/061 , C07K1/107 , C07K1/1077
摘要: A semi-recombinant method for the production of GLP-1 analogues and derivatives with non-proteogenic amino acids in the N-terminal part combining the use of recombinant expression techniques and chemical peptide synthesis.
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公开(公告)号:US07932055B2
公开(公告)日:2011-04-26
申请号:US12305678
申请日:2007-06-22
申请人: Petrus Johannes Louis Spee , Søren Berg Padkær , Birgitte Nissen Friedrichsen , Inga Sig Nielsen Nørby
发明人: Petrus Johannes Louis Spee , Søren Berg Padkær , Birgitte Nissen Friedrichsen , Inga Sig Nielsen Nørby
IPC分类号: C07K14/725 , C12P21/00
CPC分类号: C12N15/62 , C07K14/7056 , C07K14/70596 , G01N2333/70596
摘要: Soluble versions of heterodimeric receptors, e.g., CD94/NKG2 receptors, and methods of producing and using such constructs, are described. The constructs comprise soluble fragments of, each receptor monomer, and some constructs further comprise at least one immunoglobulin Fc domain. Exemplary constructs are those wherein (1) each soluble fragment is linked to an immunoglobulin Fc domain, which are then allowed to dimerize, (2) each soluble fragment is linked to an immunoglobulin Fc domain mutated to promote forced dimerization with the correct counterpart, and (3) single-chain constructs where the monomeric receptor fragments are linked, and the C-terminal fragment is linked to an Fc domain.
摘要翻译: 描述了异二聚体受体的可溶性形式,例如CD94 / NKG2受体,以及生产和使用这些构建体的方法。 构建体包含每个受体单体的可溶性片段,并且一些构建体还包含至少一个免疫球蛋白Fc结构域。 示例性构建体是其中(1)每个可溶性片段连接到免疫球蛋白Fc结构域,然后允许其二聚化,(2)每个可溶性片段连接到突变的免疫球蛋白Fc结构域以促进与正确对应物的强制二聚化,以及 (3)其中连接单体受体片段的单链构建体,并且C-末端片段连接于Fc结构域。
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