Soluble heterodimeric CD94/NKG2 receptors fusion proteins
    6.
    发明授权
    Soluble heterodimeric CD94/NKG2 receptors fusion proteins 有权
    可溶性异二聚体CD94 / NKG2受体融合蛋白

    公开(公告)号:US07932055B2

    公开(公告)日:2011-04-26

    申请号:US12305678

    申请日:2007-06-22

    IPC分类号: C07K14/725 C12P21/00

    摘要: Soluble versions of heterodimeric receptors, e.g., CD94/NKG2 receptors, and methods of producing and using such constructs, are described. The constructs comprise soluble fragments of, each receptor monomer, and some constructs further comprise at least one immunoglobulin Fc domain. Exemplary constructs are those wherein (1) each soluble fragment is linked to an immunoglobulin Fc domain, which are then allowed to dimerize, (2) each soluble fragment is linked to an immunoglobulin Fc domain mutated to promote forced dimerization with the correct counterpart, and (3) single-chain constructs where the monomeric receptor fragments are linked, and the C-terminal fragment is linked to an Fc domain.

    摘要翻译: 描述了异二聚体受体的可溶性形式,例如CD94 / NKG2受体,以及生产和使用这些构建体的方法。 构建体包含每个受体单体的可溶性片段,并且一些构建体还包含至少一个免疫球蛋白Fc结构域。 示例性构建体是其中(1)每个可溶性片段连接到免疫球蛋白Fc结构域,然后允许其二聚化,(2)每个可溶性片段连接到突变的免疫球蛋白Fc结构域以促进与正确对应物的强制二聚化,以及 (3)其中连接单体受体片段的单链构建体,并且C-末端片段连接于Fc结构域。