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    Novel Glucagon Analogues
    1.
    发明申请
    Novel Glucagon Analogues 审中-公开
    新型胰高血糖素类似物

    公开(公告)号：US20140031278A1

    公开(公告)日：2014-01-30

    申请号：US13984185

    申请日：2012-03-28

    申请人： Jesper F. Lau ,  Thomas Kruse ,  Henning Thoegersen ,  Thomas Nylandsted Krogh ,  Ulrich Sensfuss

    发明人： Jesper F. Lau ,  Thomas Kruse ,  Henning Thoegersen ,  Thomas Nylandsted Krogh ,  Ulrich Sensfuss

    IPC分类号： C07K14/605 ,  A61K45/06 ,  A61K38/26

    CPC分类号： C07K14/605 ,  A61K38/26 ,  A61K45/06 ,  A61K47/64

    摘要： The present invention relates to novel glucagon peptides with improved stability and solubility at neutral pH, to the use of the compounds in therapy, to methods of treatment comprising administration of the compounds to patients in need thereof, and to the use of the compounds in the manufacture of medicaments. The glucagon peptides of the invention are of particular interest in relation to the treatment of hyperglycemia, diabetes and obesity, as well as a variety of diseases or conditions associated with hyperglycemia, diabetes and obesity.

    摘要翻译： 本发明涉及在中性pH下具有改善的稳定性和溶解度的新型胰高血糖素肽，在治疗中使用该化合物的方法，包括向有需要的患者施用化合物，以及该化合物在 制药。 本发明的胰高血糖素肽与治疗高血糖症，糖尿病和肥胖以及与高血糖症，糖尿病和肥胖相关的各种疾病或病症有特别的关注。

    NOVEL GLUCAGON ANALOGUES
    3.
    发明申请
    NOVEL GLUCAGON ANALOGUES 审中-公开
    新的GLUCAGON ANALOGUES

    公开(公告)号：US20130143798A1

    公开(公告)日：2013-06-06

    申请号：US13637522

    申请日：2011-03-28

    申请人： Jesper F. Lau ,  Thomas Kruse ,  Lars Linderoth ,  Henning Thoegersen

    发明人： Jesper F. Lau ,  Thomas Kruse ,  Lars Linderoth ,  Henning Thoegersen

    IPC分类号： C07K14/605 ,  A61K47/48

    CPC分类号： C07K14/605 ,  A61K38/00 ,  A61K38/26 ,  A61K38/28 ,  A61K47/542 ,  A61K47/545

    摘要： The present invention relates to novel peptide compounds which have an improved physical stability in solution and improved solubility at neutral pH, to the use of the compounds in therapy, to methods of treatment comprising administration of the compounds to patients in need thereof, and to the use of the compounds in the manufacture of medicaments. The compounds of the invention are of particular interest in relation to the treatment of hyperglycemia, diabetes and obesity, as well as a variety of diseases or conditions associated with hyperglycemia, diabetes and obesity.

    摘要翻译： 本发明涉及在溶液中具有改善的物理稳定性和在中性pH下改善的溶解度，化合物在治疗中的用途的新型肽化合物，包括向有需要的患者施用化合物的治疗方法，以及 化合物在制造药物中的用途。 本发明的化合物在治疗高血糖症，糖尿病和肥胖以及与高血糖症，糖尿病和肥胖相关的各种疾病或病症方面特别有意义。

    NOVEL GLUCAGON ANALOGUES
    7.
    发明申请
    NOVEL GLUCAGON ANALOGUES 审中-公开
    新的GLUCAGON ANALOGUES

    公开(公告)号：US20130053310A1

    公开(公告)日：2013-02-28

    申请号：US13637527

    申请日：2011-03-28

    申请人： Jesper F. Lau ,  Thomas Kruse

    发明人： Jesper F. Lau ,  Thomas Kruse

    IPC分类号： C07K14/605 ,  A61P3/08 ,  A61K38/26

    CPC分类号： C07K14/605 ,  A61K38/00

    摘要： The present invention relates to glucagon peptide agonists which have improved solubility and stability, to the use of the peptides in therapy, to methods of treatment comprising administration of the peptides to patients in need thereof, and to the use of the peptides in the manufacture of medicaments. The glucagon peptides of the invention are of particular interest in relation to the treatment of hypoglycemia, diabetes and obesity, as well as a variety of diseases or conditions associated with hypoglycemia, diabetes and obesity.

    摘要翻译： 本发明涉及胰高血糖素肽激动剂，其在治疗中使用肽具有改善的溶解度和稳定性，包括向有需要的患者施用肽以及使用肽来制备 药物。 本发明的胰高血糖素肽与治疗低血糖症，糖尿病和肥胖症以及与低血糖，糖尿病和肥胖相关的各种疾病或病症有特别的关注。