公开(公告)号：US20090143418A1

公开(公告)日：2009-06-04

申请号：US12263231

申请日：2008-10-31

申请人： Jesse R. Dixon ,  Omer H. Yilmaz ,  Sean J. Morrison

发明人： Jesse R. Dixon ,  Omer H. Yilmaz ,  Sean J. Morrison

IPC分类号： A61K31/435 ,  A61K31/436

CPC分类号： A61K31/435 ,  A61K31/436

摘要： The present invention relates to compositions and methods for the preventing, treating, and researching discoloration (e.g., hair graying, hair whitening, undesired change in hair color). In particular, the present invention provides compositions and methods for treating, preventing and researching hair discoloration through inhibition of mTOR function (e.g., mTOR activity, mTOR expression). In addition, the present invention provides methods and compositions that utilize mTOR inhibiting agents in the preventing, treating, and researching hair discoloration.

摘要翻译： 本发明涉及用于预防，治疗和研究变色的组合物和方法（例如头发变灰，毛发美白，毛发颜色的不期望的变化）。 特别地，本发明提供通过抑制mTOR功能（例如，mTOR活性，mTOR表达）来治疗，预防和研究毛发变色的组合物和方法。 此外，本发明提供利用mTOR抑制剂预防，治疗和研究头发变色的方法和组合物。

公开(公告)号：US08383404B2

公开(公告)日：2013-02-26

申请号：US13012139

申请日：2011-01-24

申请人： Omer H. Yilmaz ,  Mark J. Kiel ,  Sean Morrison ,  Toshihide Iwashita

发明人： Omer H. Yilmaz ,  Mark J. Kiel ,  Sean Morrison ,  Toshihide Iwashita

IPC分类号： C12N5/0789 ,  C12N5/074

CPC分类号： C12N5/0647

摘要： The present invention relates to methods of identifying, collecting and isolating hematopoietic stem cells (HSCs) and compositions of purified HSCs. Specifically, the present invention provides methods of isolating and purifying CD150+ HSCs, CD48− HSCs, and CD244− HSCs. The present invention also relates to purified cell samples with enriched CD150+ HSCs, CD48− HSCs, and CD244− HSCs populations, as well as methods of treating subjects with such compositions.

摘要翻译： 本发明涉及鉴定，收集和分离造血干细胞（HSCs）和纯化的HSC的组合物的方法。 具体地说，本发明提供了分离和纯化CD150 + HSC，CD48-HSC和CD244-HSC的方法。 本发明还涉及具有富集的CD150 + HSC，CD48-HSC和CD244-HSCs群体的纯化细胞样品，以及用这种组合物治疗受试者的方法。

公开(公告)号：US20090227019A1

公开(公告)日：2009-09-10

申请号：US12389143

申请日：2009-02-19

申请人： Omer H. Yilmaz ,  Mark J. Kiel ,  Sean Morrison ,  Toshihide Iwashita

发明人： Omer H. Yilmaz ,  Mark J. Kiel ,  Sean Morrison ,  Toshihide Iwashita

IPC分类号： C12N5/08

CPC分类号： C12N5/0647

摘要： The present invention relates to methods of identifying, collecting and isolating hematopoietic stem cells (HSCs) and compositions of purified HSCs. Specifically, the present invention provides methods of isolating and purifying CD150+ HSCs, CD48− HSCs, and CD244− HSCs. The present invention also relates to purified cell samples with enriched CD150+ HSCs, CD48− HSCs, and CD244− HSCs populations, as well as methods of treating subjects with such compositions.

摘要翻译： 本发明涉及鉴定，收集和分离造血干细胞（HSCs）和纯化的HSC的组合物的方法。 具体地说，本发明提供了分离和纯化CD150 + HSC，CD48-HSC和CD244-HSC的方法。 本发明还涉及具有富集的CD150 + HSC，CD48-HSC和CD244-HSCs群体的纯化细胞样品，以及用这种组合物治疗受试者的方法。

公开(公告)号：US07510877B2

公开(公告)日：2009-03-31

申请号：US10950784

申请日：2004-09-27

申请人： Omer H. Yilmaz ,  Mark J. Kiel ,  Sean Morrison ,  Toshihide Iwashita

发明人： Omer H. Yilmaz ,  Mark J. Kiel ,  Sean Morrison ,  Toshihide Iwashita

IPC分类号： C12N5/08 ,  C12N5/00

CPC分类号： C12N5/0647

摘要： The present invention relates to methods of identifying, collecting and isolating hematopoietic stem cells (HSCs) and compositions of purified HSCs. Specifically, the present invention provides methods of isolating and purifying CD150+ HSCs, CD48− HSCs, and CD244− HSCs. The present invention also relates to purified cell samples with enriched CD150+ HSCs, CD48− HSCs, and CD244− HSCs populations, as well as methods of treating subjects with such compositions.

摘要翻译： 本发明涉及鉴定，收集和分离造血干细胞（HSCs）和纯化的HSC的组合物的方法。 具体地说，本发明提供了分离和纯化CD150 + HSC，CD48-HSC和CD244-HSC的方法。 本发明还涉及具有富集的CD150 + HSC，CD48-HSC和CD244-HSCs群体的纯化细胞样品，以及用这种组合物治疗受试者的方法。

公开(公告)号：US20110143430A1

公开(公告)日：2011-06-16

申请号：US13012139

申请日：2011-01-24

申请人： Omer H. Yilmaz ,  Mark J. Kiel ,  Sean Morrison ,  Toshihide Iwashita

发明人： Omer H. Yilmaz ,  Mark J. Kiel ,  Sean Morrison ,  Toshihide Iwashita

IPC分类号： C12N5/00

CPC分类号： C12N5/0647

摘要： The present invention relates to methods of identifying, collecting and isolating hematopoietic stem cells (HSCs) and compositions of purified HSCs. Specifically, the present invention provides methods of isolating and purifying CD150+ HSCs, CD48− HSCs, and CD244− HSCs. The present invention also relates to purified cell samples with enriched CD150+ HSCs, CD48− HSCs, and CD244− HSCs populations, as well as methods of treating subjects with such compositions.

摘要翻译： 本发明涉及鉴定，收集和分离造血干细胞（HSCs）和纯化的HSC的组合物的方法。 具体地说，本发明提供了分离和纯化CD150 + HSC，CD48-HSC和CD244-HSC的方法。 本发明还涉及具有富集的CD150 + HSC，CD48-HSC和CD244-HSCs群体的纯化细胞样品，以及用这种组合物治疗受试者的方法。

公开(公告)号：US07919316B2

公开(公告)日：2011-04-05

申请号：US12389143

申请日：2009-02-19

申请人： Omer H. Yilmaz ,  Mark J. Kiel ,  Sean Morrison ,  Toshihide Iwashita

发明人： Omer H. Yilmaz ,  Mark J. Kiel ,  Sean Morrison ,  Toshihide Iwashita

IPC分类号： C12N5/0789 ,  C12N5/074

CPC分类号： C12N5/0647

摘要： The present invention relates to methods of identifying, collecting and isolating hematopoietic stem cells (HSCs) and compositions of purified HSCs. Specifically, the present invention provides methods of isolating and purifying CD150+ HSCs, CD48− HSCs, and CD244− HSCs. The present invention also relates to purified cell samples with enriched CD150+ HSCs, CD48− HSCs, and CD244− HSCs populations, as well as methods of treating subjects with such compositions.

摘要翻译： 本发明涉及鉴定，收集和分离造血干细胞（HSCs）和纯化的HSC的组合物的方法。 具体地说，本发明提供了分离和纯化CD150 + HSC，CD48-HSC和CD244-HSC的方法。 本发明还涉及具有富集的CD150 + HSC，CD48-HSC和CD244-HSCs群体的纯化细胞样品，以及用这种组合物治疗受试者的方法。