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12 条记录 (耗时 0.038 秒)

    ISOLATION AND USE OF SOLID TUMOR STEM CELLS
    1.
    发明申请
    ISOLATION AND USE OF SOLID TUMOR STEM CELLS 有权
    分离和使用固体肿瘤干细胞

    公开(公告)号：US20110092378A1

    公开(公告)日：2011-04-21

    申请号：US12979991

    申请日：2010-12-28

    申请人： Michael F. Clarke ,  Sean J. Morrison ,  Max S. Wicha ,  Muhammad Al-Hajj

    发明人： Michael F. Clarke ,  Sean J. Morrison ,  Max S. Wicha ,  Muhammad Al-Hajj

    IPC分类号： C12Q1/68 ,  C12N5/09 ,  G01N33/566 ,  C40B30/00

    CPC分类号： C12N5/0693 ,  C12N5/0695 ,  C12N2503/00 ,  G01N33/5011 ,  G01N33/57492

    摘要： A small percentage of cells within an established solid tumor have the properties of stem cells. These solid tumor stem cells give rise to both more tumor stem cells and to the majority of cells in the tumor that have lost the capacity for extensive proliferation and the ability to give rise to new tumors. Thus, solid tumor heterogeneity reflects the presence of tumor cell progeny arising from a solid tumor stem cell.We have developed a xenograft model in which we have been able to establish tumors from primary tumors via injection of tumors in the mammary gland of severely immunodeficient mice. These xenograft assay have allowed us to do biological and molecular assays to characterize clonogenic solid tumor stem cells.We have also developed evidence that strongly implicates the Notch pathway, especially Notch 4, as playing a central pathway in carcinogenesis.

    摘要翻译： 建立的实体瘤内的一小部分细胞具有干细胞的特性。 这些实体肿瘤干细胞产生更多的肿瘤干细胞和肿瘤中大部分已经失去广泛增殖能力和产生新肿瘤的能力的细胞。 因此，实体肿瘤异质性反映了由固体肿瘤干细胞产生的肿瘤细胞后代的存在。 我们已经开发了异种移植模型，其中我们已经能够通过在严重免疫缺陷小鼠的乳腺中注射肿瘤来从原发肿瘤中建立肿瘤。 这些异种移植物测定使我们能够进行生物学和分子测定来表征克隆型实体瘤干细胞。 我们还发现证据强烈地暗示Notch途径，特别是Notch 4，作为致癌过程的中心途径。

    Isolation and use of solid tumor stem cells
    5.
    发明授权
    Isolation and use of solid tumor stem cells 有权
    实体肿瘤干细胞的分离和使用

    公开(公告)号：US08357491B2

    公开(公告)日：2013-01-22

    申请号：US12979991

    申请日：2010-12-28

    申请人： Michael F. Clarke ,  Sean J. Morrison ,  Max S. Wicha ,  Muhammad Al-Hajj

    发明人： Michael F. Clarke ,  Sean J. Morrison ,  Max S. Wicha ,  Muhammad Al-Hajj

    IPC分类号： C12Q1/68 ,  C12P19/34

    CPC分类号： C12N5/0693 ,  C12N5/0695 ,  C12N2503/00 ,  G01N33/5011 ,  G01N33/57492

    摘要： A small percentage of cells within an established solid tumor have the properties of stem cells. These solid tumor stem cells give rise to both more tumor stem cells and to the majority of cells in the tumor that have lost the capacity for extensive proliferation and the ability to give rise to new tumors. Thus, solid tumor heterogeneity reflects the presence of tumor cell progeny arising from a solid tumor stem cell.We have developed a xenograft model in which we have been able to establish tumors from primary tumors via injection of tumors in the mammary gland of severely immunodeficient mice. These xenograft assay have allowed us to do biological and molecular assays to characterize clonogenic solid tumor stem cells.We have also developed evidence that strongly implicates the Notch pathway, especially Notch 4, as playing a central pathway in carcinogenesis.

    摘要翻译： 建立的实体瘤内的一小部分细胞具有干细胞的特性。 这些实体肿瘤干细胞产生更多的肿瘤干细胞和肿瘤中大部分已经失去广泛增殖能力和产生新肿瘤的能力的细胞。 因此，实体肿瘤异质性反映了由固体肿瘤干细胞产生的肿瘤细胞后代的存在。 我们已经开发了异种移植模型，其中我们已经能够通过在严重免疫缺陷小鼠的乳腺中注射肿瘤从原发肿瘤中建立肿瘤。 这些异种移植物测定使我们能够进行生物学和分子测定来表征克隆型实体瘤干细胞。 我们还发现证据强烈地暗示Notch途径，特别是Notch 4，作为致癌过程的中心途径。

    Compositions and Methods for Preventing and Treating Hair Growth Cycle-Related Conditions
    6.
    发明申请
    Compositions and Methods for Preventing and Treating Hair Growth Cycle-Related Conditions 审中-公开
    用于预防和治疗头发生长周期相关条件的组合物和方法

    公开(公告)号：US20090143418A1

    公开(公告)日：2009-06-04

    申请号：US12263231

    申请日：2008-10-31

    申请人： Jesse R. Dixon ,  Omer H. Yilmaz ,  Sean J. Morrison

    发明人： Jesse R. Dixon ,  Omer H. Yilmaz ,  Sean J. Morrison

    IPC分类号： A61K31/435 ,  A61K31/436

    CPC分类号： A61K31/435 ,  A61K31/436

    摘要： The present invention relates to compositions and methods for the preventing, treating, and researching discoloration (e.g., hair graying, hair whitening, undesired change in hair color). In particular, the present invention provides compositions and methods for treating, preventing and researching hair discoloration through inhibition of mTOR function (e.g., mTOR activity, mTOR expression). In addition, the present invention provides methods and compositions that utilize mTOR inhibiting agents in the preventing, treating, and researching hair discoloration.

    摘要翻译： 本发明涉及用于预防，治疗和研究变色的组合物和方法（例如头发变灰，毛发美白，毛发颜色的不期望的变化）。 特别地，本发明提供通过抑制mTOR功能（例如，mTOR活性，mTOR表达）来治疗，预防和研究毛发变色的组合物和方法。 此外，本发明提供利用mTOR抑制剂预防，治疗和研究头发变色的方法和组合物。

    Isolation and use of solid tumor stem cells
    7.
    发明申请
    Isolation and use of solid tumor stem cells 审中-公开
    实体肿瘤干细胞的分离和使用

    公开(公告)号：US20080194022A1

    公开(公告)日：2008-08-14

    申请号：US11788489

    申请日：2007-04-20

    申请人： Michael F. Clarke ,  Sean J. Morrison ,  Max S. Wicha ,  Muhammad Al-Hajj

    发明人： Michael F. Clarke ,  Sean J. Morrison ,  Max S. Wicha ,  Muhammad Al-Hajj

    IPC分类号： C12N5/06

    CPC分类号： C12N5/0693 ,  C12N5/0695 ,  C12N2503/00 ,  G01N33/5011 ,  G01N33/57492

    摘要： A small percentage of cells within an established solid tumor have the properties of stem cells. These solid tumor stem cells give rise both to more tumor stem cells and to the majority of cells in the tumor that have lost the capacity for extensive proliferation and the ability to give rise to new tumors. Thus, solid tumor heterogeneity reflects the presence of tumor cell progeny arising from a solid tumor stem cell.We have developed a xenograft model in which we have been able to establish tumors from primary tumors via injection of tumors in the mammary gland of severely immunodeficient mice. These xenograft assay have allowed us to do biological and molecular assays to characterize clonogenic solid tumor stem cells.We have also developed evidence that strongly implicates the Notch pathway, especially Notch 4, as playing a central pathway in carcinogenesis.

    摘要翻译： 建立的实体瘤内的一小部分细胞具有干细胞的特性。 这些实体肿瘤干细胞产生更多的肿瘤干细胞和肿瘤中大部分已经失去广泛增殖能力的细胞和产生新肿瘤的能力。 因此，实体肿瘤异质性反映了由固体肿瘤干细胞产生的肿瘤细胞后代的存在。 我们已经开发了异种移植模型，其中我们已经能够通过在严重免疫缺陷小鼠的乳腺中注射肿瘤从原发肿瘤中建立肿瘤。 这些异种移植物测定使我们能够进行生物学和分子测定来表征克隆型实体瘤干细胞。 我们还发现证据强烈地暗示Notch途径，特别是Notch 4，作为致癌过程的中心途径。

    ISOLATION AND USE OF SOLID TUMOR STEM CELLS
    9.
    发明申请
    ISOLATION AND USE OF SOLID TUMOR STEM CELLS 审中-公开
    分离和使用固体肿瘤干细胞

    公开(公告)号：US20140011274A1

    公开(公告)日：2014-01-09

    申请号：US13714921

    申请日：2012-12-14

    申请人： Michael F. Clarke ,  Sean J. Morrison ,  Max S. Wicha ,  Muhammad Al-Hajj

    发明人： Michael F. Clarke ,  Sean J. Morrison ,  Max S. Wicha ,  Muhammad Al-Hajj

    IPC分类号： C12N5/09

    CPC分类号： C12N5/0693 ,  C12N5/0695 ,  C12N2503/00 ,  G01N33/5011 ,  G01N33/57492

    摘要： A small percentage of cells within an established solid tumor have the properties of stem cells. These solid tumor stem cells give rise to both more tumor stem cells and to the majority of cells in the tumor that have lost the capacity for extensive proliferation and the ability to give rise to new tumors. Thus, solid tumor heterogeneity reflects the presence of tumor cell progeny arising from a solid tumor stem cell.We have developed a xenograft model in which we have been able to establish tumors from primary tumors via injection of tumors in the mammary gland of severely immunodeficient mice. These xenograft assay have allowed us to do biological and molecular assays to characterize clonogenic solid tumor stem cells.We have also developed evidence that strongly implicates the Notch pathway, especially Notch 4, as playing a central pathway in carcinogenesis.

    摘要翻译： 建立的实体瘤内的一小部分细胞具有干细胞的特性。 这些实体肿瘤干细胞产生更多的肿瘤干细胞和肿瘤中大部分已经失去广泛增殖能力和产生新肿瘤的能力的细胞。 因此，实体肿瘤异质性反映了由固体肿瘤干细胞产生的肿瘤细胞后代的存在。 我们已经开发了异种移植模型，其中我们已经能够通过在严重免疫缺陷小鼠的乳腺中注射肿瘤从原发肿瘤中建立肿瘤。 这些异种移植物测定使我们能够进行生物学和分子测定来表征克隆型实体瘤干细胞。 我们还发现证据强烈地暗示Notch途径，特别是Notch 4，作为致癌过程的中心途径。