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1.发明授权Purified and isolated heparan sulfate 3-O-sulfotransferase isoform 5 nucleic acids and polypeptides and therapeutic and screening methods using same 有权纯化和分离的硫酸乙酰肝素3-O-磺基转移酶同工型5核酸和多肽以及使用其的治疗和筛选方法公开(公告)号：US07531338B2
公开(公告)日：2009-05-12
申请号：US10520341
申请日：2003-07-07
申请人： Jian Liu , Guoqing Xia , Jinghua Chen , Michael B. Duncan , Deepak Shukla , Vaibhav Tiwari , Anders Malmstrom
发明人： Jian Liu , Guoqing Xia , Jinghua Chen , Michael B. Duncan , Deepak Shukla , Vaibhav Tiwari , Anders Malmstrom
CPC分类号： C12N9/13 , A01K2217/05 , A61K38/00 , A61K2039/505 , C12N2799/026 , C12N2799/028
摘要： 3-OST-5 proteins, and nucleic acid molecules encoding the same. Recombinant host cells, recombinant nucleic acids and recombinant proteins are also disclosed, along with methods of producing each. Isolated and purified antibodies to 3-OST-5 homologs, and methods of producing the same, are also disclosed. 3OST-5 gene products have biological activity in specific heparan sulfate 3-O-sulfotransferase reactions. These reactions provide unique modified heparan sulfate. Thus, therapeutic methods involving this activity are also disclosed.
摘要翻译： 3-OST-5蛋白和编码它们的核酸分子。 还公开了重组宿主细胞，重组核酸和重组蛋白，以及各自产生的方法。 还公开了对3-OST-5同系物的分离和纯化的抗体及其制备方法。 3OST-5基因产物在特异性硫酸乙酰肝素3-O-磺基转移酶反应中具有生物活性。 这些反应提供了独特的改性硫酸乙酰肝素。 因此，还公开了涉及该活性的治疗方法。
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2.发明申请Purified and isolated heparan sulfate 3-o-sulfotransferase isoform 5 nucleic acids and polypeptides and therapeutic and screening methods using same 有权纯化和分离的硫酸乙酰肝素3-o-磺基转移酶同工型5核酸和多肽以及使用其的治疗和筛选方法公开(公告)号：US20060165673A1
公开(公告)日：2006-07-27
申请号：US10520341
申请日：2003-07-07
申请人： Jian Liu , Guoqing Xia , Jinghua Chen , Michael Duncan , Deepark Shuka , Vaibhav Tiwari , Anders Malmstrom
发明人： Jian Liu , Guoqing Xia , Jinghua Chen , Michael Duncan , Deepark Shuka , Vaibhav Tiwari , Anders Malmstrom
CPC分类号： C12N9/13 , A01K2217/05 , A61K38/00 , A61K2039/505 , C12N2799/026 , C12N2799/028
摘要： 3-OST-5 proteins, and nucleic acid molecules encoding the same. Recombinant host cells, recombinant nucleic acids and recombinant proteins are also disclosed, along with methods of producing each. Isolated and purified antibodies to 3-OST-5 homologs, and methods of producing the same, are also disclosed. 3OST-5 gene products have biological activity in specific heparan sulfate 3-O-sulfotransferase reactions. These reactions provide unique modified heparan sulfate. Thus, therapeutic methods involving this activity are also disclosed.
摘要翻译： 3-OST-5蛋白和编码它们的核酸分子。 还公开了重组宿主细胞，重组核酸和重组蛋白，以及各自产生的方法。 还公开了对3-OST-5同系物的分离和纯化的抗体及其制备方法。 3OST-5基因产物在特异性硫酸乙酰肝素3-O-磺基转移酶反应中具有生物活性。 这些反应提供了独特的改性硫酸乙酰肝素。 因此，还公开了涉及该活性的治疗方法。
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