公开(公告)号：US10422007B2

公开(公告)日：2019-09-24

申请号：US14774212

申请日：2014-03-10

申请人： Jianwei Che ,  Jennifer Harris ,  Hsin-I Hsieh ,  Jie Li ,  Jun Liu ,  Nicholas Ng

发明人： Jianwei Che ,  Jennifer Harris ,  Hsin-I Hsieh ,  Jie Li ,  Jun Liu ,  Nicholas Ng

IPC分类号： C12Q1/6886 ,  A61K31/444 ,  A61K31/497 ,  A61K31/501 ,  G01N33/574

摘要： The invention provides methods of monitoring differential gene expression of biomarkers to determine patient sensitivity to Wnt inhibitor, methods of determining the sensitivity of a cell to an Wnt inhibitor by measuring biomarkers, methods of screening for candidate Wnt inhibitor, Wnt inhibitor for use in head and neck squamous cell carcinoma.

公开(公告)号：US20160024587A1

公开(公告)日：2016-01-28

申请号：US14774212

申请日：2014-03-10

申请人： Jianwei CHE ,  Jennifer HARRIS ,  Hsin-I HSIEH ,  Jie LI ,  Jun LIU ,  Nicholas NG

发明人： Jianwei Che ,  Jennifer Harris ,  Hsin-I Hsieh ,  Jie Li ,  Jun Liu ,  Nicholas Ng

IPC分类号： C12Q1/68 ,  A61K31/497

摘要： The invention provides methods of monitoring differential gene expression of biomarkers to determine patient sensitivity to Wnt inhibitor, methods of determining the sensitivity of a cell to an Wnt inhibitor by measuring biomarkers, methods of screening for candidate Wnt inhibitor, Wnt inhibitor for use in head and neck squamous cell carcinoma.

摘要翻译： 本发明提供监测生物标志物的差异基因表达以确定患者对Wnt抑制剂的敏感性的方法，通过测量生物标志物来测定细胞对Wnt抑制剂的敏感性的方法，筛选候选Wnt抑制剂的方法，用于头部的Wnt抑制剂和 颈鳞状细胞癌。