公开(公告)号：US10422007B2

公开(公告)日：2019-09-24

申请号：US14774212

申请日：2014-03-10

Applicant: Jianwei Che ,  Jennifer Harris ,  Hsin-I Hsieh ,  Jie Li ,  Jun Liu ,  Nicholas Ng

Inventor： Jianwei Che ,  Jennifer Harris ,  Hsin-I Hsieh ,  Jie Li ,  Jun Liu ,  Nicholas Ng

IPC: C12Q1/6886 ,  A61K31/444 ,  A61K31/497 ,  A61K31/501 ,  G01N33/574

Abstract: The invention provides methods of monitoring differential gene expression of biomarkers to determine patient sensitivity to Wnt inhibitor, methods of determining the sensitivity of a cell to an Wnt inhibitor by measuring biomarkers, methods of screening for candidate Wnt inhibitor, Wnt inhibitor for use in head and neck squamous cell carcinoma.

公开(公告)号：US20160024587A1

公开(公告)日：2016-01-28

申请号：US14774212

申请日：2014-03-10

Applicant: Jianwei CHE ,  Jennifer HARRIS ,  Hsin-I HSIEH ,  Jie LI ,  Jun LIU ,  Nicholas NG

Inventor： Jianwei Che ,  Jennifer Harris ,  Hsin-I Hsieh ,  Jie Li ,  Jun Liu ,  Nicholas Ng

IPC: C12Q1/68 ,  A61K31/497

Abstract: The invention provides methods of monitoring differential gene expression of biomarkers to determine patient sensitivity to Wnt inhibitor, methods of determining the sensitivity of a cell to an Wnt inhibitor by measuring biomarkers, methods of screening for candidate Wnt inhibitor, Wnt inhibitor for use in head and neck squamous cell carcinoma.

Abstract translation: 本发明提供监测生物标志物的差异基因表达以确定患者对Wnt抑制剂的敏感性的方法，通过测量生物标志物来测定细胞对Wnt抑制剂的敏感性的方法，筛选候选Wnt抑制剂的方法，用于头部的Wnt抑制剂和 颈鳞状细胞癌。

公开(公告)号：US08722692B2

公开(公告)日：2014-05-13

申请号：US13386645

申请日：2010-07-30

Applicant: Jianwei Che ,  Qiang Ding ,  Xiaohui He ,  Hong Liu ,  Yahua Liu ,  Pierre-Yves Michellys ,  Barun Okram ,  Xu Wu ,  Kunyong Yang ,  Xuefeng Zhu

Inventor： Jianwei Che ,  Qiang Ding ,  Xiaohui He ,  Hong Liu ,  Yahua Liu ,  Pierre-Yves Michellys ,  Barun Okram ,  Xu Wu ,  Kunyong Yang ,  Xuefeng Zhu

IPC: A01N43/90 ,  A61K31/519 ,  C07D471/00 ,  C07D487/00

CPC classification number: C07D471/04

Abstract: Provided herein are a novel class of compounds of Formula (I), pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated Syk kinase activity.

Abstract translation: 本文提供了一类新的式（I）化合物，包含这些化合物的药物组合物和使用这些化合物治疗或预防与异常或失调的Syk激酶活性相关的疾病或病症的方法。

公开(公告)号：US08354526B2

公开(公告)日：2013-01-15

申请号：US12865367

申请日：2009-01-27

Applicant: Qiang Ding ,  Yahua Liu ,  Xu Wu ,  Qihui Jin ,  Jianwei Che ,  S. Frank Yan

Inventor： Qiang Ding ,  Yahua Liu ,  Xu Wu ,  Qihui Jin ,  Jianwei Che ,  S. Frank Yan

IPC: C07D345/00

CPC classification number: C07D471/04

Abstract: The invention provides a class of compounds of Formula (I), pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly Syk, ZAP70, KDR, FMS, FLT3, c-Kit, RET, TrkA, TrkB, TrkC, IGR-IR, AIk, c-FMS, or combinations thereof.

Abstract translation: 本发明提供一类式（I）的化合物，包含这些化合物的药物组合物和使用这些化合物治疗或预防与异常或失调的激酶活性相关的疾病或病症的方法，特别是Syk，ZAP70，KDR，FMS，FLT3， c-Kit，RET，TrkA，TrkB，TrkC，IGR-IR，AIk，c-FMS或其组合。

公开(公告)号：US20120184526A1

公开(公告)日：2012-07-19

申请号：US13386645

申请日：2010-07-30

Applicant: Jianwei Che ,  Qiang Ding ,  Xiaohui He ,  Hong Liu ,  Yahua Liu ,  Pierre-Yves Michellys ,  Barun Okram ,  Xu Wu ,  Kunyong Yang ,  Xuefeng Zhu

Inventor： Jianwei Che ,  Qiang Ding ,  Xiaohui He ,  Hong Liu ,  Yahua Liu ,  Pierre-Yves Michellys ,  Barun Okram ,  Xu Wu ,  Kunyong Yang ,  Xuefeng Zhu

IPC: A61K31/5377 ,  A61K31/519 ,  A61P35/00 ,  A61P37/08 ,  A61P29/00 ,  A61P19/02 ,  C07D471/04 ,  A61K31/496

CPC classification number: C07D471/04

Abstract: Provided herein are a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated Syk kinase activity.

Abstract translation: 本文提供了一类新颖的化合物，包含这些化合物的药物组合物和使用这些化合物治疗或预防与异常或失调的Syk激酶活性相关的疾病或病症的方法。

公开(公告)号：US20110053897A1

公开(公告)日：2011-03-03

申请号：US12843771

申请日：2010-07-26

Applicant: Jianwei CHE ,  Bei Chen ,  Qiang Ding ,  Xueshi Hao ,  Xiaohui He ,  Songchun Jiang ,  Qihui Jin ,  Yunho Jin ,  Hong Liu ,  Yahua Liu ,  Barun Okram ,  Tetsuo Uno ,  Xu Wu ,  Kunyong Yang ,  Xuefeng Zhu

Inventor： Jianwei CHE ,  Bei Chen ,  Qiang Ding ,  Xueshi Hao ,  Xiaohui He ,  Songchun Jiang ,  Qihui Jin ,  Yunho Jin ,  Hong Liu ,  Yahua Liu ,  Barun Okram ,  Tetsuo Uno ,  Xu Wu ,  Kunyong Yang ,  Xuefeng Zhu

IPC: A61K31/635 ,  C07D471/04 ,  A61K31/497 ,  A61K31/5377 ,  A61K31/506 ,  A61K31/444 ,  A61P11/06 ,  A61P19/02 ,  A61P35/00 ,  A61P7/06 ,  A61P25/00

CPC classification number: C07D471/04 ,  A61K31/4375

Abstract: Provided herein area novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated Syk kinase activity.

Abstract translation: 本文提供了区域新颖的化合物类，包含这些化合物的药物组合物和使用这些化合物治疗或预防与异常或失调的Syk激酶活性相关的疾病或病症的方法。

公开(公告)号：US20110003798A1

公开(公告)日：2011-01-06

申请号：US12865339

申请日：2009-01-27

Applicant: Barun Okram ,  Tetsuo Uno ,  Qiang Ding ,  Yahua Liu ,  Yunho Jin ,  Qihui Jin ,  Xu Wu ,  Jianwei Che ,  S. Frank Yan ,  Xueshi Hao

Inventor： Barun Okram ,  Tetsuo Uno ,  Qiang Ding ,  Yahua Liu ,  Yunho Jin ,  Qihui Jin ,  Xu Wu ,  Jianwei Che ,  S. Frank Yan ,  Xueshi Hao

IPC: A61K31/5415 ,  C07D471/04 ,  C07D498/04 ,  A61K31/4375 ,  A61K31/5377 ,  A61K31/506 ,  A61K31/496 ,  A61K31/541 ,  A61K31/497 ,  A61K31/538 ,  A61K31/5383 ,  A61K31/501 ,  A61P11/06 ,  A61P11/08 ,  A61P11/00 ,  A61P17/00 ,  A61P17/06 ,  A61P11/02 ,  A61P29/00 ,  A61P25/00 ,  A61P35/00 ,  A61P31/18 ,  A61P37/02

CPC classification number: C07D471/04

Abstract: The invention provides a novel class of 2,7-naphthyridin derivatives; pharmaceutical compositions comprising such compounds and methods of using such compounds to treat o prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly Syk, ZAP70, KDR, FMS, FLT*, c-Kit, RET, TrkA, TrkB, TrkC-GR-1R, Alk, c-FMS or combinations thereof.

Abstract translation: 本发明提供了一类新的2,7-萘啶衍生物; 包含这些化合物的药物组合物和使用这些化合物治疗的方法o预防与异常或失调的激酶活性相关的疾病或病症，特别是Syk，ZAP70，KDR，FMS，FLT *，c-Kit，RET，TrkA，TrkB，TrkC- GR-1R，Alk，c-FMS或其组合。

公开(公告)号：US08546370B2

公开(公告)日：2013-10-01

申请号：US12865339

申请日：2009-01-27

Applicant: Barun Okram ,  Tetsuo Uno ,  Qiang Ding ,  Yahua Liu ,  Yunho Jin ,  Qihui Jin ,  Xu Wu ,  Jianwei Che ,  S. Frank Yan ,  Xueshi Hao

Inventor： Barun Okram ,  Tetsuo Uno ,  Qiang Ding ,  Yahua Liu ,  Yunho Jin ,  Qihui Jin ,  Xu Wu ,  Jianwei Che ,  S. Frank Yan ,  Xueshi Hao

IPC: A61K31/33

CPC classification number: C07D471/04

Abstract: The invention provides a novel class of 2,7-naphthyridin derivatives; pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly Syk, ZAP70, KDR, FMS, FLT3, c-Kit, RET, TrkA, TrkB, TrkC-GR-1R, Alk, c-FMS, or combinations thereof.

Abstract translation: 本发明提供了一类新的2,7-萘啶衍生物; 包含这些化合物的药物组合物和使用这些化合物治疗或预防与异常或失调激酶活性相关的疾病或病症的方法，特别是Syk，ZAP70，KDR，FMS，FLT3，c-Kit，RET，TrkA，TrkB，TrkC-GR -1R，Alk，c-FMS或其组合。

公开(公告)号：US20110003790A1

公开(公告)日：2011-01-06

申请号：US12865367

申请日：2009-01-27

Applicant: Qiang Ding ,  Yahua Liu ,  Xu Wu ,  Qihui Jin ,  Jianwei Che ,  S. Frank Yan

Inventor： Qiang Ding ,  Yahua Liu ,  Xu Wu ,  Qihui Jin ,  Jianwei Che ,  S. Frank Yan

IPC: A61K31/519 ,  C07D213/75 ,  C07D471/04 ,  C07D498/04 ,  A61K31/397 ,  A61K31/5377 ,  A61K31/497 ,  A61K31/5383 ,  A61K31/551 ,  A61K31/541 ,  A61P11/08 ,  A61P11/00 ,  A61P11/02 ,  A61P17/00 ,  A61P17/06 ,  A61P29/00 ,  A61P25/00 ,  A61P35/00 ,  A61P31/18 ,  A61P37/02

CPC classification number: C07D471/04

Abstract: The invention provides a class of compounds of Formula (I), pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly Syk, ZAP70, KDR, FMS, FLT3, c-Kit, RET, TrkA, TrkB, TrkC, IGR-IR, AIk, c-FMS, or combinations thereof.

Abstract translation: 本发明提供一类式（I）的化合物，包含这些化合物的药物组合物和使用这些化合物治疗或预防与异常或失调的激酶活性相关的疾病或病症的方法，特别是Syk，ZAP70，KDR，FMS，FLT3， c-Kit，RET，TrkA，TrkB，TrkC，IGR-IR，AIk，c-FMS或其组合。

公开(公告)号：US20050214788A1

公开(公告)日：2005-09-29

申请号：US10939115

申请日：2004-09-09

Applicant: Jianwei Che

Inventor： Jianwei Che

IPC: C12Q1/68 ,  C40B30/02 ,  G01N33/48 ,  G01N33/50 ,  G01N33/53 ,  G01N33/68 ,  G06F19/00 ,  G06F19/16 ,  G06G20060101

CPC classification number: G01N33/6803 ,  G16C20/50 ,  G16C20/70

Abstract: Methods and/or systems for modeling molecular systems and/or other physical systems using scaling optimization.

Abstract translation: 用于使用缩放优化建模分子系统和/或其他物理系统的方法和/或系统。