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公开(公告)号：US08415469B2
公开(公告)日：2013-04-09
申请号：US12616079
申请日：2009-11-10
申请人： Prabha N. Ibrahim , Dean R. Artis , Ryan Bremer , Gaston Habets , Shumeye Mamo , Marika Nespi , Chao Zhang , Jiazhong Zhang , Yong-Liang Zhu , Rebecca Zuckerman , Brian West , Yoshisa Suzuki , Jianming Tsai , Klaus-Peter Hirth , Gideon Bollag , Wayne Spevak , Hanna Cho , Samuel J. Gillette , Guoxian Wu , Hongyao Zhu , Shenghua Shi
发明人： Prabha N. Ibrahim , Dean R. Artis , Ryan Bremer , Gaston Habets , Shumeye Mamo , Marika Nespi , Chao Zhang , Jiazhong Zhang , Yong-Liang Zhu , Rebecca Zuckerman , Brian West , Yoshisa Suzuki , Jianming Tsai , Klaus-Peter Hirth , Gideon Bollag , Wayne Spevak , Hanna Cho , Samuel J. Gillette , Guoxian Wu , Hongyao Zhu , Shenghua Shi
IPC分类号： C07D413/14 , C07D401/14 , C07D471/04 , C07F7/02
CPC分类号： C07D471/04 , A61K31/437 , A61K31/496 , A61K31/5377 , C07C37/62 , C07C39/27 , C07C45/00 , C07C45/673 , C07C45/71 , C07C47/565 , C07C47/575 , C07D209/08
摘要： Compounds active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.
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公开(公告)号：US08461169B2
公开(公告)日：2013-06-11
申请号：US12958379
申请日：2010-12-01
申请人： Jiazhong Zhang , Prabha N. Ibrahim , Dean R. Artis , Ryan Bremer , Guoxian Wu , Hongyao Zhu , Marika Nespi , Chao Zhang
发明人： Jiazhong Zhang , Prabha N. Ibrahim , Dean R. Artis , Ryan Bremer , Guoxian Wu , Hongyao Zhu , Marika Nespi , Chao Zhang
IPC分类号： A61K31/505 , A61K31/44
CPC分类号： C07D471/04 , A61K31/444 , A61K31/497 , A61K31/506 , A61K31/5377 , A61K45/06
摘要： Compounds active on the receptor protein tyrosine kinases c-kit and/or c-fms are provided herewith. Also provided herewith are compositions useful for treatment of c-kit mediated diseases or conditions and/or c-fms-mediated diseases or conditions, and methods for the use thereof.
摘要翻译： 本文提供了对受体蛋白酪氨酸激酶c-kit和/或c-fms活性的化合物。 本文还提供了可用于治疗c-kit介导的疾病或病症和/或c-fms介导的疾病或病症的组合物及其使用方法。
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公开(公告)号：US20110230482A1
公开(公告)日：2011-09-22
申请号：US12958379
申请日：2010-12-01
申请人： Jiazhong Zhang , Prabha N. Ibrahim , Dean R. Artis , Ryan Bremer , Guoxian Wu , Hongyao Zhu , Marika Nespi , Chao Zhang
发明人： Jiazhong Zhang , Prabha N. Ibrahim , Dean R. Artis , Ryan Bremer , Guoxian Wu , Hongyao Zhu , Marika Nespi , Chao Zhang
IPC分类号： A61K31/437 , A61K31/497 , A61K31/5377 , A61K31/506 , A61P35/00 , A61P35/02 , A61P35/04 , A61P19/02 , A61P11/06 , A61P3/10 , A61P3/04 , A61P19/08 , A61P19/10
CPC分类号： C07D471/04 , A61K31/444 , A61K31/497 , A61K31/506 , A61K31/5377 , A61K45/06
摘要： Compounds active on the receptor protein tyrosine kinases c-kit and/or c-fms are provided herewith. Also provided herewith are compositions useful for treatment of c-kit mediated diseases or conditions and/or c-fms-mediated diseases or conditions, and methods for the use thereof.
摘要翻译： 本文提供了对受体蛋白酪氨酸激酶c-kit和/或c-fms活性的化合物。 本文还提供了可用于治疗c-kit介导的疾病或病症和/或c-fms介导的疾病或病症的组合物及其使用方法。
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4.发明申请公开(公告)号：US20120309756A1
公开(公告)日：2012-12-06
申请号：US13546923
申请日：2012-07-11
申请人： Jiazhong Zhang , Prabha N. Ibrahim , Dean R. Artis , Ryan Bremer , Guoxian Wu , Hongyao Zhu , Marika Nespi , Chao Zhang
发明人： Jiazhong Zhang , Prabha N. Ibrahim , Dean R. Artis , Ryan Bremer , Guoxian Wu , Hongyao Zhu , Marika Nespi , Chao Zhang
IPC分类号： C07D471/04 , A61K31/506 , A61K31/497 , A61K31/444 , A61K31/5377
CPC分类号： C07D471/04 , A61K31/444 , A61K31/497 , A61K31/506 , A61K31/5377 , A61K45/06
摘要： Compounds active on the receptor protein tyrosine kinases c-kit and/or c-fms are provided herewith. Also provided herewith are compositions useful for treatment of c-kit mediated diseases or conditions and/or c-fms-mediated diseases or conditions, and methods for the use thereof.
摘要翻译： 本文提供了对受体蛋白酪氨酸激酶c-kit和/或c-fms活性的化合物。 本文还提供了可用于治疗c-kit介导的疾病或病症和/或c-fms介导的疾病或病症的组合物及其使用方法。
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公开(公告)号：US20120053177A1
公开(公告)日：2012-03-01
申请号：US13243748
申请日：2011-09-23
申请人： Prabha N. Ibrahim , Dean R. Artis , Ryan Bremer , Gaston Habets , Shumeye Mamo , Marika Nespi , Chao Zhang , Jiazhong Zhang , Yong-Liang Zhu , Rebecca Zuckerman , Brian West , Yoshisa Suzuki , James Tsai , Klaus-Peter Hirth , Gideon Bollag , Wayne Spevak , Hanna Cho , Samuel J. Gillette , Guoxian Wu , Hongyao Zhu , Shenghua Shi
发明人： Prabha N. Ibrahim , Dean R. Artis , Ryan Bremer , Gaston Habets , Shumeye Mamo , Marika Nespi , Chao Zhang , Jiazhong Zhang , Yong-Liang Zhu , Rebecca Zuckerman , Brian West , Yoshisa Suzuki , James Tsai , Klaus-Peter Hirth , Gideon Bollag , Wayne Spevak , Hanna Cho , Samuel J. Gillette , Guoxian Wu , Hongyao Zhu , Shenghua Shi
IPC分类号： A61K31/5377 , A61P35/00 , A61K31/496 , A61K31/506 , C12N9/99 , A61K31/437
CPC分类号： C07D471/04 , A61K31/437 , A61K31/496 , A61K31/5377 , C07C37/62 , C07C39/27 , C07C45/00 , C07C45/673 , C07C45/71 , C07C47/565 , C07C47/575 , C07D209/08
摘要： Compounds active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.
摘要翻译： 描述了对蛋白激酶有活性的化合物，以及使用这些化合物治疗与蛋白激酶异常活性相关的疾病和病症的方法。
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6.发明授权公开(公告)号：US07893075B2
公开(公告)日：2011-02-22
申请号：US11986667
申请日：2007-11-21
申请人： Jiazhong Zhang , Prabha N. Ibrahim , Dean R. Artis , Ryan Bremer , Guoxian Wu , Hongyao Zhu , Marika Nespi , Chao Zhang
发明人： Jiazhong Zhang , Prabha N. Ibrahim , Dean R. Artis , Ryan Bremer , Guoxian Wu , Hongyao Zhu , Marika Nespi , Chao Zhang
IPC分类号： A61K31/506 , A61K31/454 , A61P35/00 , C07D471/04 , C07D239/02
CPC分类号： C07D471/04 , A61K31/444 , A61K31/497 , A61K31/506 , A61K31/5377 , A61K45/06
摘要： Compounds active on the receptor protein tyrosine kinases c-kit and/or c-fms are provided herewith. Also provided herewith are compositions useful for treatment of c-kit mediated diseases or conditions and/or c-fms-mediated diseases or conditions, and methods for the use thereof.
摘要翻译： 本文提供了对受体蛋白酪氨酸激酶c-kit和/或c-fms活性的化合物。 本文还提供了可用于治疗c-kit介导的疾病或病症和/或c-fms介导的疾病或病症的组合物及其使用方法。
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公开(公告)号：US08404700B2
公开(公告)日：2013-03-26
申请号：US13546923
申请日：2012-07-11
申请人： Prabha N. Ibrahim , Dean R. Artis , Ryan Bremer , Guoxian Wu , Hongyao Zhu , Marika Nespi , Chao Zhang , Jiazhong Zhang
发明人： Prabha N. Ibrahim , Dean R. Artis , Ryan Bremer , Guoxian Wu , Hongyao Zhu , Marika Nespi , Chao Zhang , Jiazhong Zhang
IPC分类号： A61K31/506 , A61K31/454 , A61P35/00 , C07D471/04 , C07D239/02
CPC分类号： C07D471/04 , A61K31/444 , A61K31/497 , A61K31/506 , A61K31/5377 , A61K45/06
摘要： Compounds active on the receptor protein tyrosine kinases c-kit and/or c-fms are provided herewith. Also provided herewith are compositions useful for treatment of c-kit mediated diseases or conditions and/or c-fms-mediated diseases or conditions, and methods for the use thereof.
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公开(公告)号：US20100256365A1
公开(公告)日：2010-10-07
申请号：US12616079
申请日：2009-11-10
申请人： Prabha N. Ibrahim , Dean R. Artis , Ryan Bremer , Gaston Habets , Shumeye Mamo , Marika Nespi , Chao Zhang , Jiazhong Zhang , Yong-Liang Zhu , Rebecca Zuckerman , Brian West , Yoshisa Suzuki , James Tsai , Klaus-Peter Hirth , Gideon Bollag , Wayne Spevak , Hanna Cho , Samuel J. Gillette , Guoxian Wu , Hongyao Zhu , Shenghua Shi
发明人： Prabha N. Ibrahim , Dean R. Artis , Ryan Bremer , Gaston Habets , Shumeye Mamo , Marika Nespi , Chao Zhang , Jiazhong Zhang , Yong-Liang Zhu , Rebecca Zuckerman , Brian West , Yoshisa Suzuki , James Tsai , Klaus-Peter Hirth , Gideon Bollag , Wayne Spevak , Hanna Cho , Samuel J. Gillette , Guoxian Wu , Hongyao Zhu , Shenghua Shi
IPC分类号： C07D413/14 , C07D401/14 , C07F7/02 , C07D471/04
CPC分类号： C07D471/04 , A61K31/437 , A61K31/496 , A61K31/5377 , C07C37/62 , C07C39/27 , C07C45/00 , C07C45/673 , C07C45/71 , C07C47/565 , C07C47/575 , C07D209/08
摘要： Compounds active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.
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9.发明申请公开(公告)号：US20090076046A1
公开(公告)日：2009-03-19
申请号：US11986667
申请日：2007-11-21
申请人： Jiazhong Zhang , Prabha N. Ibrahim , Dean R. Artis , Ryan Bremer , Guoxian Wu , Hongyao Zhu , Marika Nespi , Chao Zhang
发明人： Jiazhong Zhang , Prabha N. Ibrahim , Dean R. Artis , Ryan Bremer , Guoxian Wu , Hongyao Zhu , Marika Nespi , Chao Zhang
IPC分类号： A61K31/506 , A61P35/00 , C07D471/04 , A61K31/454 , C07D239/02
CPC分类号： C07D471/04 , A61K31/444 , A61K31/497 , A61K31/506 , A61K31/5377 , A61K45/06
摘要： Compounds active on the receptor protein tyrosine kinases c-kit and/or c-fms are provided herewith. Also provided herewith are compositions useful for treatment of c-kit mediated diseases or conditions and/or c-fms-mediated diseases or conditions, and methods for the use thereof.
摘要翻译： 本文提供了对受体蛋白酪氨酸激酶c-kit和/或c-fms活性的化合物。 本文还提供了可用于治疗c-kit介导的疾病或病症和/或c-fms介导的疾病或病症的组合物及其使用方法。
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10.发明申请公开(公告)号：US20110166174A1
公开(公告)日：2011-07-07
申请号：US12958376
申请日：2010-12-01
申请人： Chao Zhang , Jiazhong Zhang , Prabha N. Ibrahim , Clarence R. Hurt , Rebecca Zuckerman , Dean R. Artis , Ryan Bremer , Wayne Spevak , Guoxian Wu , Hongyao Zhu
发明人： Chao Zhang , Jiazhong Zhang , Prabha N. Ibrahim , Clarence R. Hurt , Rebecca Zuckerman , Dean R. Artis , Ryan Bremer , Wayne Spevak , Guoxian Wu , Hongyao Zhu
IPC分类号： A61K31/437 , A61P37/08 , A61P11/06 , A61P19/02 , A61P25/00 , A61P41/00 , A61P3/10 , A61P1/00 , A61P27/02
CPC分类号： C07D471/04
摘要： Compounds active on the receptor protein tyrosine kinases c-kit and c-fms are provided herewith. Also provided herewith are compositions useful for treatment of c-kit mediated diseases or condition and c-fms-mediated diseases or condition, and methods for the use thereof.
摘要翻译： 本文提供了对受体蛋白酪氨酸激酶c-kit和c-fms有活性的化合物。 本文还提供了可用于治疗c-kit介导的疾病或病症和c-fms介导的疾病或病症的组合物及其使用方法。
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