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公开(公告)号：US20100047356A1
公开(公告)日：2010-02-25
申请号：US12440715
申请日：2007-09-11
IPC分类号： A61K9/50 , A61K31/403 , A61K31/404 , A61K31/655 , A61K31/473 , A61K31/122 , A61K31/4184 , A61K31/535 , A61P35/00 , A61P17/00
CPC分类号： A61K9/5089
摘要： Novel phototherapeutic methods and compositions are described herein. Nanoparticle-assembled microcapsules as a new type of delivery vehicle for photosensitive compounds may be synthesized through a two-step assembly process. Charged polymer chains and counterions may be combined with a photosensitive compound to form photosensitive aggregates, and then nanoparticles may be combined with the aggregates to form the microcapsules. The shell may be composed of nanoparticles and/or polymer, and the core interior may contain the photosensitive compound. Formation occurs rapidly (on the order of seconds) and the conditions are very mild (at room temperature, in aqueous solution, and at neutral pH). The microcapsule synthesis is highly suitable as an encapsulation method, particularly for a charged photosensitive molecule like ICG.
摘要翻译： 本文描述了新的光疗法和组合物。 作为光敏化合物的新型载体的纳米颗粒组装微胶囊可以通过两步组装方法合成。 带电的聚合物链和抗衡离子可以与光敏化合物组合以形成光敏聚集体，然后将纳米颗粒与聚集体组合以形成微胶囊。 壳可以由纳米颗粒和/或聚合物组成，并且核心内部可以含有光敏化合物。 形成迅速（秒数），条件非常温和（室温下，水溶液中，中性pH值）。 微胶囊合成作为包封方法是非常适合的，特别是对于带电感光分子如ICG。
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公开(公告)号：US08337809B2
公开(公告)日：2012-12-25
申请号：US12440715
申请日：2007-09-11
CPC分类号： A61K9/5089
摘要： Novel phototherapeutic methods and compositions are described herein. Nanoparticle-assembled microcapsules as a new type of delivery vehicle for photosensitive compounds may be synthesized through a two-step assembly process. Charged polymer chains and counterions may be combined with a photosensitive compound to form photosensitive aggregates, and then nanoparticles may be combined with the aggregates to form the microcapsules. The shell may be composed of nanoparticles and/or polymer, and the core interior may contain the photosensitive compound. Formation occurs rapidly (on the order of seconds) and the conditions are very mild (at room temperature, in aqueous solution, and at neutral pH). The microcapsule synthesis is highly suitable as an encapsulation method, particularly for a charged photosensitive molecule like ICG.
摘要翻译： 本文描述了新的光疗法和组合物。 作为光敏化合物的新型载体的纳米颗粒组装微胶囊可以通过两步组装方法合成。 带电的聚合物链和抗衡离子可以与光敏化合物组合以形成光敏聚集体，然后将纳米颗粒与聚集体组合以形成微胶囊。 壳可以由纳米颗粒和/或聚合物组成，并且核心内部可以含有光敏化合物。 形成迅速（秒数），条件非常温和（室温下，水溶液中，中性pH值）。 微胶囊合成作为包封方法是非常适合的，特别是对于带电感光分子如ICG。
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