公开(公告)号：US08311620B2

公开(公告)日：2012-11-13

申请号：US11895025

申请日：2007-08-22

申请人： Jihong Qu ,  Haris J. Sih ,  Mark Schwartz ,  Prashant Sinha

发明人： Jihong Qu ,  Haris J. Sih ,  Mark Schwartz ,  Prashant Sinha

IPC分类号： A61B5/04 ,  A61K9/22

CPC分类号： A61N1/3621 ,  A61M5/14276 ,  A61N1/0568 ,  A61N1/0587 ,  A61N1/3962

摘要： The invention provides a cardiac rhythm management system which includes a tachyarrhythmia detection and classification circuit programmed to detect and classify a tachyarrhythmia, a biologic therapy delivery device configured to deliver or regulate an expression cassette suitable for terminating or preventing atrial fibrillation (AF), and a control circuit coupled to the tachyarrhythmia detection and classification circuit and the biologic therapy delivery device. Also provided is an implantable medical device for use in a body having a cardiovascular system, which includes an implantable device body including at least a cardiovascular portion configured to be in the cardiovascular system, and an expression cassette incorporated into the cardiovascular portion of the implantable device body, the expression cassette selected to express a gene product that terminates or prevents AF. Further provided are methods which employ particular expression cassettes to prevent, inhibit or treat AF.

摘要翻译： 本发明提供一种心律管理系统，其包括程序化以检测和分类快速性心律失常的快速性心律失常检测和分类电路，构造成递送或调节适于终止或预防心房颤动（AF）的表达盒的生物治疗递送装置，以及 耦合到快速心律失常检测和分类电路的控制电路和生物治疗递送装置。 还提供了一种用于具有心血管系统的身体的可植入医疗装置，其包括可植入装置主体，该可植入装置主体至少包括构造成在心血管系统中的心血管部分，以及结合到可植入装置的心血管部分中的表达盒 身体，选择表达终止或预防AF的基因产物的表达盒。 还提供了采用特定表达盒来预防，抑制或治疗房颤的方法。

公开(公告)号：US20090054943A1

公开(公告)日：2009-02-26

申请号：US11895025

申请日：2007-08-22

申请人： Jihong Qu ,  Haris J. Sih ,  Mark Schwartz ,  Prashant Sinha

发明人： Jihong Qu ,  Haris J. Sih ,  Mark Schwartz ,  Prashant Sinha

IPC分类号： A61N1/05 ,  A61N1/18 ,  A61N1/362

CPC分类号： A61N1/3621 ,  A61M5/14276 ,  A61N1/0568 ,  A61N1/0587 ,  A61N1/3962

摘要： The invention provides a cardiac rhythm management system which includes a tachyarrhythmia detection and classification circuit programmed to detect and classify a tachyarrhythmia, a biologic therapy delivery device configured to deliver or regulate an expression cassette suitable for terminating or preventing atrial fibrillation (AF), and a control circuit coupled to the tachyarrhythmia detection and classification circuit and the biologic therapy delivery device. Also provided is an implantable medical device for use in a body having a cardiovascular system, which includes an implantable device body including at least a cardiovascular portion configured to be in the cardiovascular system, and an expression cassette incorporated into the cardiovascular portion of the implantable device body, the expression cassette selected to express a gene product that terminates or prevents AF. Further provided are methods which employ particular expression cassettes to prevent, inhibit or treat AF.

摘要翻译： 本发明提供一种心律管理系统，其包括程序化以检测和分类快速性心律失常的快速性心律失常检测和分类电路，构造成递送或调节适于终止或预防心房颤动（AF）的表达盒的生物治疗递送装置，以及 耦合到快速心律失常检测和分类电路的控制电路和生物治疗递送装置。 还提供了一种用于具有心血管系统的身体的可植入医疗装置，其包括可植入装置主体，该可植入装置主体至少包括构造成在心血管系统中的心血管部分，以及结合到可植入装置的心血管部分中的表达盒 身体，选择表达终止或预防AF的基因产物的表达盒。 还提供了采用特定表达盒来预防，抑制或治疗房颤的方法。

公开(公告)号：US07676407B2

公开(公告)日：2010-03-09

申请号：US10832181

申请日：2004-04-26

申请人： David J Van De Van ,  Prashant Sinha ,  Moshin Dawoodbhai

发明人： David J Van De Van ,  Prashant Sinha ,  Moshin Dawoodbhai

IPC分类号： G06Q40/00

CPC分类号： G06Q40/02 ,  G06Q20/102 ,  G06Q20/12 ,  G06Q20/40 ,  G06Q40/00 ,  G06Q40/12 ,  G06Q50/188

摘要： Systems and methods are provided for an online purchasing system. In one embodiment, the online system includes business logic for approving a purchase requisition having a plurality of itemized goods and service and requiring approval by a plurality of authorized approvers on a line item by line item basis. An approval table defining identified authorized approver and conditions under which the authorized approvers must approve specified line items in a particular purchase request is generated by the online purchasing system to enable approvers of the purchase requisition to monitor the status of the particular purchase request. In a second embodiment, the online purchasing system through extracting business logic identified a second group of authorized approver and conditions under which the authorized approvers must approve specified line items.

摘要翻译： 为在线采购系统提供系统和方法。 在一个实施例中，在线系统包括用于批准具有多个逐项商品和服务的购买申请的业务逻辑，并且需要由多个授权批准者在逐行项目的基础上批准。 定义确定的授权批准人和授权批准人必须批准特定购买请求中的指定行项目的条件的批准表由在线采购系统生成，以使采购申请的审批人能够监视特定购买请求的状态。 在第二实施例中，通过提取业务逻辑的在线购买系统识别出授权审批者必须批准指定行项目的第二组授权审批者和条件。

公开(公告)号：US20050240493A1

公开(公告)日：2005-10-27

申请号：US10832046

申请日：2004-04-26

申请人： Hallie Johnson ,  Christine Jamison ,  David Van ,  Prashant Sinha

发明人： Hallie Johnson ,  Christine Jamison ,  David Van ,  Prashant Sinha

IPC分类号： G06Q30/00 ,  G06F17/60

CPC分类号： G06Q30/06 ,  G06Q30/0613 ,  G06Q30/0633 ,  G06Q30/0641

摘要： Systems and methods are provided for an online purchasing system. The online system includes business logic for approving a purchase requisition having a plurality of itemized goods and service and requiring approval by a plurality of authorized approvers on a line item by line item basis. An approval table defining identified authorized approver and conditions under which the authorized approvers must approve specified line items in a particular purchase request is generated by the online purchasing system to enable approvers of the purchase requisition to monitor the status of the particular purchase request. The online purchasing system through extracting business logic identified a second group of authorized approver and conditions under which the authorized approvers must approve specified line items.

摘要翻译： 为在线采购系统提供系统和方法。 在线系统包括用于批准具有多个逐项商品和服务的购买申请的业务逻辑，并且需要由多个授权批准人在逐行项目的基础上批准。 定义确定的授权批准人和授权批准人必须批准特定购买请求中的指定行项目的条件的批准表由在线采购系统生成，以使采购申请的审批人能够监视特定购买请求的状态。 通过提取业务逻辑的在线采购系统确定了授权批准人必须批准指定的订单项的第二组授权批准人和条件。

公开(公告)号：US20050240524A1

公开(公告)日：2005-10-27

申请号：US10832181

申请日：2004-04-26

申请人： David Van De Van ,  Prashant Sinha ,  Moshin Dawoodbhai

发明人： David Van De Van ,  Prashant Sinha ,  Moshin Dawoodbhai

IPC分类号： G06Q20/00 ,  G06Q40/00 ,  G06F17/60

CPC分类号： G06Q40/02 ,  G06Q20/102 ,  G06Q20/12 ,  G06Q20/40 ,  G06Q40/00 ,  G06Q40/12 ,  G06Q50/188

摘要： Systems and methods are provided for an online purchasing system. In one embodiment, the online system includes business logic for approving a purchase requisition having a plurality of itemized goods and service and requiring approval by a plurality of authorized approvers on a line item by line item basis. An approval table defining identified authorized approver and conditions under which the authorized approvers must approve specified line items in a particular purchase request is generated by the online purchasing system to enable approvers of the purchase requisition to monitor the status of the particular purchase request. In a second embodiment, the online purchasing system through extracting business logic identified a second group of authorized approver and conditions under which the authorized approvers must approve specified line items.

摘要翻译： 为在线采购系统提供系统和方法。 在一个实施例中，在线系统包括用于批准具有多个逐项商品和服务的购买申请的业务逻辑，并且需要由多个授权批准者在逐行项目的基础上批准。 定义确定的授权批准人和授权批准人必须批准特定购买请求中的指定行项目的条件的批准表由在线采购系统生成，以使采购申请的审批人能够监视特定购买请求的状态。 在第二实施例中，通过提取业务逻辑的在线购买系统识别出授权审批者必须批准指定行项目的第二组授权审批者和条件。