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1.Novel benzamidine derivatives, process for the preparation thereof and pharmaceutical composition comprising the same 有权
标题翻译: 新型苯甲脒衍生物,其制备方法和包含其的药物组合物公开(公告)号:US20100240890A1
公开(公告)日:2010-09-23
申请号:US11659556
申请日:2005-08-04
申请人: Jin Soo Lee , Seok Hoon Ahn , Young Goo Jin , Sang Mi Jin , Whui-Jung Park , Sae Kwang Ku , Yu Ha Hwang , Pan Soo Kim , Sun Shin Yi , Jei Man Ryu
发明人: Jin Soo Lee , Seok Hoon Ahn , Young Goo Jin , Sang Mi Jin , Whui-Jung Park , Sae Kwang Ku , Yu Ha Hwang , Pan Soo Kim , Sun Shin Yi , Jei Man Ryu
IPC分类号: C07D277/30 , C07D417/04 , C07D277/40 , C07D277/48 , C07D417/12
CPC分类号: C07D417/06 , C07D277/24 , C07D277/28 , C07D277/40 , C07D277/42 , C07D277/46 , C07D277/48 , C07D277/52 , C07D417/04 , C07D417/12
摘要: The present invention relates to novel benzamidine derivatives, process for the preparation thereof and pharmaceutical composition comprising the same. The novel benzamidine derivatives of the present invention are useful for the prevention and treatment of osteoporosis, bone fractures and allergic inflammatory diseases.
摘要翻译: 本发明涉及新的苄脒衍生物,其制备方法和包含其的药物组合物。 本发明的新型苄脒衍生物可用于预防和治疗骨质疏松症,骨折和过敏性炎性疾病。
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2.Benzamidine derivatives, process for the preparation thereof and pharmaceutical composition comprising the same 有权
标题翻译: 苄脒衍生物,其制备方法和包含其的药物组合物公开(公告)号:US08178688B2
公开(公告)日:2012-05-15
申请号:US11659556
申请日:2005-08-04
申请人: Jin Soo Lee , Seok Hoon Ahn , Young Goo Jin , Sang Mi Jin , Whui-Jung Park , Sae Kwang Ku , Yun Ha Hwang , Pan Soo Kim , Sun Shin Yi , Jei Man Ryu
发明人: Jin Soo Lee , Seok Hoon Ahn , Young Goo Jin , Sang Mi Jin , Whui-Jung Park , Sae Kwang Ku , Yun Ha Hwang , Pan Soo Kim , Sun Shin Yi , Jei Man Ryu
IPC分类号: C07D277/20 , C07D277/30 , C07D417/02 , C07D417/04 , C07D417/06 , C07D417/08
CPC分类号: C07D417/06 , C07D277/24 , C07D277/28 , C07D277/40 , C07D277/42 , C07D277/46 , C07D277/48 , C07D277/52 , C07D417/04 , C07D417/12
摘要: The present invention relates to novel benzamidine derivatives, process for the preparation thereof and pharmaceutical composition comprising the same. The novel benzamidine derivatives of the present invention are useful for the prevention and treatment of osteoporosis, bone fractures and allergic inflammatory diseases.
摘要翻译: 本发明涉及新的苄脒衍生物,其制备方法和包含其的药物组合物。 本发明的新型苄脒衍生物可用于预防和治疗骨质疏松症,骨折和过敏性炎性疾病。
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3.N-hydroxy-4- {5- [4- (5-isopropyl-2-methyl-1, 3-thiazol-4-yl) phenoxy] pentoxy} benzamidine 2 methanesulfonic acid salt 审中-公开
标题翻译: N-羟基-4- {5- [4-(5-异丙基-2-甲基-1,3-噻唑-4-基)苯氧基]戊氧基}苄脒2甲磺酸盐公开(公告)号:US20090176846A1
公开(公告)日:2009-07-09
申请号:US10584984
申请日:2005-11-22
申请人: Jei Man Ryu , Jin Soo Lee , Dong Hyuk Shin , Seung Kyoo Seong , Soon Ki Cho , Chan Seok Jeon , Young Goo Jin , Ki Young Lee , Se Hyun Jung , Eun Hee Cho , Seok Hoon Ahn
发明人: Jei Man Ryu , Jin Soo Lee , Dong Hyuk Shin , Seung Kyoo Seong , Soon Ki Cho , Chan Seok Jeon , Young Goo Jin , Ki Young Lee , Se Hyun Jung , Eun Hee Cho , Seok Hoon Ahn
IPC分类号: A61K31/426 , C07D277/28
CPC分类号: C07D277/24 , A61K9/143 , A61K31/426
摘要: Disclosed is an N-Hydroxy-4-{5-[4-(5-isopropyl-2-methyl-1,3-thiazol-4-yl)phenoxy]pentoxy} benzamidine 2 methansulfonic acid salt, which has excellent bioavailability. Also disclosed are a method of preparing the compound and a pharmaceutical composition comprising the compound.
摘要翻译: 公开了具有优异生物利用度的N-羟基-4- {5- [4-(5-异丙基-2-甲基-1,3-噻唑-4-基)苯氧基]戊氧基}苄脒2甲磺酸盐。 还公开了制备该化合物的方法和包含该化合物的药物组合物。
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公开(公告)号:US20080125596A1
公开(公告)日:2008-05-29
申请号:US11631829
申请日:2005-07-05
申请人: Jin Soo Lee , Seok Hoon Ahn , Young Goo Jin , Jae Hoon Park , Dong Hyuk Shin , Eun Hee Cho , Hwan Bong Chang , Young Ho Jung
发明人: Jin Soo Lee , Seok Hoon Ahn , Young Goo Jin , Jae Hoon Park , Dong Hyuk Shin , Eun Hee Cho , Hwan Bong Chang , Young Ho Jung
IPC分类号: C07D277/20
CPC分类号: C07D277/24
摘要: This invention relates to an improved method of preparing N-hydroxy-4-{5-[4-(5-isopropyl-2-methyl-1,3-thiazol-4-yl)phenoxy]pentoxy}benzamidine.
摘要翻译: 本发明涉及一种制备N-羟基-4- {5- [4-(5-异丙基-2-甲基-1,3-噻唑-4-基)苯氧基]戊氧基}苄脒的改进方法。
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5.Process for preparing N-hydroxy-4-{5-[4-(5-isopropyl-2-methyl-1,3-thiazol-4-yl)-phenoxy]-pentoxy}-benzamidine 失效
标题翻译: 制备N-羟基-4- {5- [4-(5-异丙基-2-甲基-1,3-噻唑-4-基) - 苯氧基] - 苯氧基} - 苄脒的方法公开(公告)号:US07585979B2
公开(公告)日:2009-09-08
申请号:US11631829
申请日:2005-07-05
申请人: Jin Soo Lee , Seok Hoon Ahn , Young Goo Jin , Jae Hoon Park , Dong Hyuk Shin , Eun Hee Cho , Hwan Bong Chang , Young Ho Jung
发明人: Jin Soo Lee , Seok Hoon Ahn , Young Goo Jin , Jae Hoon Park , Dong Hyuk Shin , Eun Hee Cho , Hwan Bong Chang , Young Ho Jung
IPC分类号: C07D277/20
CPC分类号: C07D277/24
摘要: This invention relates to an improved method of preparing N-hydroxy-4-{5-[4-(5-isopropyl-2-methyl-1,3-thiazol-4-yl)phenoxy]pentoxy}benzamidine.
摘要翻译: 本发明涉及一种制备N-羟基-4- {5- [4-(5-异丙基-2-甲基-1,3-噻唑-4-基)苯氧基]戊氧基}苄脒的改进方法。
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