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4 条记录 (耗时 0.014 秒)

    Method to enhance root nodulation in legumes and inoculum preparation therefor
    1.
    发明授权
    Method to enhance root nodulation in legumes and inoculum preparation therefor 失效
    增加豆科植物根系结瘤的方法及其接种物准备

    公开(公告)号：US4878936A

    公开(公告)日：1989-11-07

    申请号：US77937

    申请日：1987-07-27

    申请人： Jo E. Handelsman ,  Larry J. Halverson

    发明人： Jo E. Handelsman ,  Larry J. Halverson

    IPC分类号： C05F11/08

    CPC分类号： C12R1/085 ,  C05F11/08 ,  Y10S435/834

    摘要： A method for enhancing nodulation in legumes growing in a growing medium. The method includes the step of placing in the growing medium in the immediate vicinity of the roots of the legume the nodulation of which is to be enhanced an effective quantity of an enhancing bacteria selected from the group consisting of ATCC 53522, enhancing mutants of ATCC 53522, a mixture of such mutants, and a mixture of such mutants with ATCC 53522.

    摘要翻译： 用于增强在生长培养基中生长的豆类中的结瘤的方法。 该方法包括将生长培养基放置在豆类根部附近的步骤，其结瘤将增强有效量的选自ATCC 53522的增强细菌，增强ATCC 53522的突变体 ，这种突变体的混合物，以及这种突变体与ATCC 53522的混合物。

    Method for modulating microbial quorum sensing
    2.
    发明授权
    Method for modulating microbial quorum sensing 有权
    调节微生物群体感知的方法

    公开(公告)号：US08063108B2

    公开(公告)日：2011-11-22

    申请号：US12712948

    申请日：2010-02-25

    申请人： Jo E. Handelsman ,  Bradley R. Borlee

    发明人： Jo E. Handelsman ,  Bradley R. Borlee

    IPC分类号： A01N35/00 ,  A01N33/18 ,  A01N33/24 ,  A61K31/12 ,  A61K31/04

    CPC分类号： A61K31/325 ,  A61K31/421 ,  A61K31/426

    摘要： The present invention provides compositions and methods for modulating bacterial quorum sensing using antagonist or agonist compounds. Further, the present invention provides methods of treating or preventing microbial damages and diseases, in particular for diseases where there is an advantage in inhibiting quorum sensing regulated phenotypes of pathogens.

    摘要翻译： 本发明提供使用拮抗剂或激动剂化合物调节细菌群体感测的组合物和方法。 此外，本发明提供了治疗或预防微生物损伤和疾病的方法，特别是在抑制群体感应调节的病原体表型方面具有优势的疾病。

    Triaryl cation antibiotics from environmental DNA
    3.
    发明授权
    Triaryl cation antibiotics from environmental DNA 失效
    来自环境DNA的三芳基阳离子抗生素

    公开(公告)号：US07115753B2

    公开(公告)日：2006-10-03

    申请号：US10637280

    申请日：2003-08-08

    申请人： Jo E. Handelsman ,  Robert M. Goodman ,  Doreen E. Gillespie ,  Alan D. Bettermann ,  Jon C. Clardy ,  Sean F. Brady

    发明人： Jo E. Handelsman ,  Robert M. Goodman ,  Doreen E. Gillespie ,  Alan D. Bettermann ,  Jon C. Clardy ,  Sean F. Brady

    IPC分类号： C07D209/16

    CPC分类号： C12P17/165 ,  A61K31/404 ,  C07D209/14 ,  C12N15/52 ,  Y02A50/473 ,  Y02A50/481

    摘要： Disclosed are triaryl cationic compounds that exhibit broad spectrum antibiotic and antifungal activity, pharmaceutical compositions containing the compounds, and methods of treating bacterial and fungal infections using the compounds. The compounds were initially isolated by screening a 25,000-member bacterial artificial chromosome (BAC) library of environmental (eDNA) from soil. At least one clone produced a dark brown melanin-like compound that was found to have antibiotic activity. The compounds were isolated and synthesized de novo. From within the positive clone, a single open reading frame that shares extensive sequence similarity with members of the 4-hydroxyphenylpyruvate family of enzymes was found to be necessary and sufficient to confer the production of at least one of the subject compounds on E. coli.

    摘要翻译： 公开了显示广谱抗生素和抗真菌活性的三芳基阳离子化合物，含有该化合物的药物组合物，以及使用该化合物治疗细菌和真菌感染的方法。 首先通过从土壤中筛选25,000个来自环境（eDNA）的细菌人造染色体（BAC）文库来分离化合物。 至少有一个克隆产生一种被发现具有抗生素活性的深棕色黑色素样化合物。 从头开始分离和合成化合物。 从阳性克隆中，发现与酶的4-羟基苯基丙酮酸家族的成员具有广泛序列相似性的单个开放阅读框是必需和足够的，以赋予大肠杆菌中至少一种主题化合物的产生。