公开(公告)号：US06600072B2

公开(公告)日：2003-07-29

申请号：US10217457

申请日：2002-08-14

申请人： Joachim Brendel ,  Heinz-Werner Kleeman ,  Heinrich Christian Englert ,  Hans Jochen Lang ,  Udo Albus ,  Bansi Lal ,  Anil Vasantrao Ghate

发明人： Joachim Brendel ,  Heinz-Werner Kleeman ,  Heinrich Christian Englert ,  Hans Jochen Lang ,  Udo Albus ,  Bansi Lal ,  Anil Vasantrao Ghate

IPC分类号： C07C23365

CPC分类号： C07C271/22

摘要： Substituted 1-naphthoylguanidines, process for their preparation, their use as a medicament or diagnostic, and medicament containing them. Substituted 1-naphthoylguanidines of the formula I in which R2 to R8 have the meanings indicated in the claims, are suitable as antiarrhythmic pharmaceuticals having a cardioprotective component for infarct prophylaxis and infarct treatment and for the treatment of angina pectoris. They also preventively inhibit the pathophysiological processes in the formation of ischemically induced damage, in particular in the production of ischemically induced cardiac arrhythmias.

摘要翻译： 取代的1-萘甲酰胍，其制备方法，它们作为药物或诊断剂的用途以及含有它们的药物。R2至R8具有权利要求中所示含义的式Iin的取代的1-萘酰基胍适合作为抗心律失常药物，其具有 用于梗死预防和梗塞治疗以及用于治疗心绞痛的心脏保护组件。 它们还预防性地抑制缺血诱导的损伤形成中的病理生理过程，特别是在缺血诱导的心律失常的产生中。

公开(公告)号：US5733934A

公开(公告)日：1998-03-31

申请号：US633223

申请日：1996-04-16

申请人： Nigrogi Venkata Satya Ramakrishna ,  Tulsidas Sitaram More ,  Anagha Suhas Kulkarni ,  Bansi Lal ,  Rao Venkata Satya Veerabhadra Vadlamudi ,  Anil Vasantrao Ghate ,  Ravindra Dattatraya Gupte ,  Wolfgang Scholz ,  Hans Jochen Lang

发明人： Nigrogi Venkata Satya Ramakrishna ,  Tulsidas Sitaram More ,  Anagha Suhas Kulkarni ,  Bansi Lal ,  Rao Venkata Satya Veerabhadra Vadlamudi ,  Anil Vasantrao Ghate ,  Ravindra Dattatraya Gupte ,  Wolfgang Scholz ,  Hans Jochen Lang

IPC分类号： A61K31/155 ,  A61K20060101 ,  A61K31/16 ,  A61K31/185 ,  A61K31/205 ,  A61K31/435 ,  A61P9/00 ,  A61P9/06 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  C07C20060101 ,  C07C277/08 ,  C07C279/22 ,  C07C279/26 ,  C07C327/50 ,  C07C327/54 ,  C07D20060101 ,  C07D295/26 ,  A01N33/02 ,  A01N37/30

CPC分类号： C07C279/22 ,  C07C2102/08

摘要： Indenoylguanidines of formula I and formula II, the process for their preparation, their use as medicaments, medicaments containing them, their use as diagnostic agents and medicaments containing them are described. Compounds I are useful for treating cardiac arrhythmias. Further they are useful as cardioprotective agents in mammals, which comprises administering the compound of formula-I or II with the above properties in combination with pharmaceutically accepted carrier to said mammal. ##STR1##

摘要翻译： 描述式I和式II的茚烯酰基胍，其制备方法，它们作为药物的用途，含有它们的药物，它们作为诊断剂的用途和含有它们的药物。 化合物I可用于治疗心律失常。 此外，它们可用作哺乳动物的心脏保护剂，其包括将具有上述性质的式I或II化合物与药学上可接受的载体组合施用于所述哺乳动物。 II。图像II

公开(公告)号：US5900436A

公开(公告)日：1999-05-04

申请号：US901099

申请日：1997-07-28

申请人： Nirogi Venkata Satya Ramakrishna ,  Arun Kumar Jain ,  Bansi Lal ,  Rao Venkata Satya Veerabhadra Vadlamudi ,  Anil Vasantrao Ghate ,  Ravindra Dattatraya Gupte ,  Andreas Weichert ,  Jan-Robert Schwark

发明人： Nirogi Venkata Satya Ramakrishna ,  Arun Kumar Jain ,  Bansi Lal ,  Rao Venkata Satya Veerabhadra Vadlamudi ,  Anil Vasantrao Ghate ,  Ravindra Dattatraya Gupte ,  Andreas Weichert ,  Jan-Robert Schwark

IPC分类号： A61K31/155 ,  A01N1/00 ,  A61K31/00 ,  A61K31/165 ,  A61P3/06 ,  A61P9/00 ,  A61P9/06 ,  A61P9/10 ,  A61P9/12 ,  A61P25/00 ,  A61P43/00 ,  C07C279/22 ,  C07C327/50 ,  C07C327/54 ,  C07C231/02 ,  C07C233/09

CPC分类号： C07C279/22 ,  C07C327/54 ,  C07C2102/08 ,  Y10S514/821

摘要： Substituted Indanylidineacetylguanidines, process for their preparation, their use as medicaments or diagnostic and medicaments containing them:Indanylidineacetylguanidines I ##STR1## and their pharmaceutically acceptable salts wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10 and X have the meanings given in the claims, are effective inhibitors of the cellular sodium/proton antiport (Na.sup.+ /H.sup.+ exchanger), which, in numerous diseases (essential hypertension, atherosclerosis, diabetes and the like) is also increased in those cells which are readily accessible for measurements, such as, for example, in erythrocytes, platelets or leukocytes. They are also advantageous for the preparation of a medicament for the treatment or prophylaxis of disorders of lipid metabolism.

摘要翻译： 取代的茚基酰基乙酰胍，其制备方法，它们作为药物或含有它们的诊断和药物的用途：茚基酰基乙酰基胍I及其药学上可接受的盐，其中R1，R2，R3，R4，R5，R6，R7，R8，R9，R10和X具有 在权利要求中给出的含义是细胞钠/质子止血剂（Na + / H +交换剂）的有效抑制剂，其在许多疾病（原发性高血压，动脉粥样硬化，糖尿病等）中在易于接近的那些细胞中也增加 用于测量，例如在红细胞，血小板或白细胞中。 它们也有利于制备用于治疗或预防脂质代谢紊乱的药物。