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公开(公告)号：US20050019785A1
公开(公告)日：2005-01-27
申请号：US10714195
申请日：2003-11-14
申请人： Joffre Baker , Maureen Cronin , Steve Shak , Jose Baselga
发明人： Joffre Baker , Maureen Cronin , Steve Shak , Jose Baselga
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/158 , C12Q2600/16
摘要： The present invention concerns prognostic markers associated with EGFR positive cancer. In particular, the invention concerns prognostic methods based on the molecular characterization of gene expression in paraffin-embedded, fixed tissue samples of EGFR-expressing cancer, which allow a physician to predict whether a patient is likely to respond well to treatment with an EGFR inhibitor.
摘要翻译： 本发明涉及与EGFR阳性癌症相关的预后标志物。 特别地，本发明涉及基于在石蜡包埋的EGFR表达癌症的固定组织样品中的基因表达的分子表征的预后方法，其允许医师预测患者是否可能对EGFR抑制剂的治疗反应良好 。
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公开(公告)号：US20070065846A1
公开(公告)日：2007-03-22
申请号：US11450973
申请日：2006-06-09
申请人： Joffre Baker , Maureen Cronin , Michael Kiefer , Steve Shak , Michael Walker
发明人： Joffre Baker , Maureen Cronin , Michael Kiefer , Steve Shak , Michael Walker
CPC分类号： G01N33/57484 , C12N15/1003 , C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/158 , C12Q2600/16 , G01N33/57415
摘要： The invention concerns sensitive methods to measure mRNA levels in biopsied tumor tissues, including archived paraffin-embedded biopsy material. Th invention also concerns breast cancer gene sets important in the diagnosis and treatment of breast cancer, and methods for assigning the most optimal treatment options to breast cancer patient based upon knowledge derived from gene expression studies.
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公开(公告)号：US20070141588A1
公开(公告)日：2007-06-21
申请号：US11450961
申请日：2006-06-09
申请人： Joffre Baker , Maureen Cronin , Michael Kiefer , Steve Shak , Michael Walker
发明人： Joffre Baker , Maureen Cronin , Michael Kiefer , Steve Shak , Michael Walker
IPC分类号： C12Q1/68
CPC分类号： G01N33/57484 , C12N15/1003 , C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/158 , C12Q2600/16 , G01N33/57415
摘要： The invention concerns sensitive methods to measure mRNA levels in biopsied tumor tissues, including archived paraffin-embedded biopsy material. The invention also concerns breast cancer gene sets important in the diagnosis and treatment of breast cancer, and methods for assigning the most optimal treatment options to breast cancer patient based upon knowledge derived from gene expression studies.
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公开(公告)号：US20070065845A1
公开(公告)日：2007-03-22
申请号：US11450964
申请日：2006-06-09
申请人： Joffre Baker , Maureen Cronin , Michael Kiefer , Steve Shak , Michael Walker
发明人： Joffre Baker , Maureen Cronin , Michael Kiefer , Steve Shak , Michael Walker
CPC分类号： G01N33/57484 , C12N15/1003 , C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/158 , C12Q2600/16 , G01N33/57415
摘要： The invention concerns sensitive methods to measure mRNA levels in biopsied tumor tissues, including archived paraffin-embedded biopsy material. Th invention also concerns breast cancer gene sets important in the diagnosis and treatment of breast cancer, and methods for assigning the most optimal treatment options to breast cancer patient based upon knowledge derived from gene expression studies.
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公开(公告)号：US20070141589A1
公开(公告)日：2007-06-21
申请号：US11450963
申请日：2006-06-09
申请人： Joffre Baker , Maureen Cronin , Michael Kiefer , Steve Shak , Michael Walker
发明人： Joffre Baker , Maureen Cronin , Michael Kiefer , Steve Shak , Michael Walker
IPC分类号： C12Q1/68
CPC分类号： G01N33/57484 , C12N15/1003 , C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/158 , C12Q2600/16 , G01N33/57415
摘要： The invention concerns sensitive methods to measure mRNA levels in biopsied tumor tissues, including archived paraffin-embedded biopsy material. The invention also concerns breast cancer gene sets important in the diagnosis and treatment of breast cancer, and methods for assigning the most optimal treatment options to breast cancer patient based upon knowledge derived from gene expression studies.
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公开(公告)号：US20070141587A1
公开(公告)日：2007-06-21
申请号：US11450896
申请日：2006-06-09
申请人： Joffre Baker , Maureen Cronin , Michael Kiefer , Steve Shak , Michael Walker
发明人： Joffre Baker , Maureen Cronin , Michael Kiefer , Steve Shak , Michael Walker
IPC分类号： C12Q1/68
CPC分类号： G01N33/57484 , C12N15/1003 , C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/158 , C12Q2600/16 , G01N33/57415
摘要： The invention concerns sensitive methods to measure mRNA levels in biopsied tumor tissues, including archived paraffin-embedded biopsy material. The invention also concerns breast cancer gene sets important in the diagnosis and treatment of breast cancer, and methods for assigning the most optimal treatment options to breast cancer patient based upon knowledge derived from gene expression studies.
摘要翻译： 本发明涉及测量活检肿瘤组织中的mRNA水平的敏感方法，包括归档石蜡包埋的活检材料。 本发明还涉及在乳腺癌诊断和治疗中重要的乳腺癌基因集，以及基于从基因表达研究获得的知识为乳腺癌患者分配最佳治疗选择的方法。
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公开(公告)号：US20070059737A1
公开(公告)日：2007-03-15
申请号：US11450962
申请日：2006-06-09
申请人： Joffre Baker , Maureen Cronin , Michael Kiefer , Steve Shak , Michael Walker
发明人： Joffre Baker , Maureen Cronin , Michael Kiefer , Steve Shak , Michael Walker
IPC分类号： C12Q1/68
CPC分类号： G01N33/57484 , C12N15/1003 , C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/158 , C12Q2600/16 , G01N33/57415
摘要： The invention concerns sensitive methods to measure mRNA levels in biopsied tumor tissues, including archived paraffin-embedded biopsy material. Th invention also concerns breast cancer gene sets important in the diagnosis and treatment of breast cancer, and methods for assigning the most optimal treatment options to breast cancer patient based upon knowledge derived from gene expression studies.
摘要翻译： 本发明涉及测量活检肿瘤组织中的mRNA水平的敏感方法，包括归档石蜡包埋的活检材料。 本发明还涉及在乳腺癌的诊断和治疗中重要的乳腺癌基因集，以及基于来自基因表达研究的知识为乳腺癌患者分配最佳治疗选择的方法。
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公开(公告)号：US08008003B2
公开(公告)日：2011-08-30
申请号：US10714195
申请日：2003-11-14
申请人： Joffre B. Baker , Maureen T. Cronin , Steve Shak , Jose Baselga
发明人： Joffre B. Baker , Maureen T. Cronin , Steve Shak , Jose Baselga
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/158 , C12Q2600/16
摘要： The present invention concerns prognostic markers associated with EGFR positive cancer. In particular, the invention concerns prognostic methods based on the molecular characterization of gene expression in paraffin-embedded, fixed tissue samples of EGFR-expressing cancer, which allow a physician to predict whether a patient is likely to respond well to treatment with an EGFR inhibitor.
摘要翻译： 本发明涉及与EGFR阳性癌症相关的预后标志物。 特别地，本发明涉及基于在石蜡包埋的EGFR表达癌症的固定组织样品中的基因表达的分子表征的预后方法，其允许医师预测患者是否可能对EGFR抑制剂的治疗反应良好 。
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公开(公告)号：US20120178644A1
公开(公告)日：2012-07-12
申请号：US13347555
申请日：2012-01-10
申请人： Joffre B. Baker , Maureen T. Cronin , Steve Shak , Jose Baselga
发明人： Joffre B. Baker , Maureen T. Cronin , Steve Shak , Jose Baselga
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/158 , C12Q2600/16
摘要： The present invention concerns prognostic markers associated with EGFR positive cancer. In particular, the invention concerns prognostic methods based on the molecular characterization of gene expression in paraffin-embedded, fixed tissue samples of EGFR-expressing cancer, which allow a physician to predict whether a patient is likely to respond well to treatment with an EGFR inhibitor.
摘要翻译： 本发明涉及与EGFR阳性癌症相关的预后标志物。 特别地，本发明涉及基于在石蜡包埋的EGFR表达癌症的固定组织样品中的基因表达的分子表征的预后方法，其允许医师预测患者是否可能对EGFR抑制剂的治疗反应良好 。
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公开(公告)号：US20110245102A1
公开(公告)日：2011-10-06
申请号：US13150799
申请日：2011-06-01
申请人： Joffre B. Baker , Maureen T. Cronin , Steve Shak , Jose Baselga
发明人： Joffre B. Baker , Maureen T. Cronin , Steve Shak , Jose Baselga
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/158 , C12Q2600/16
摘要： The present invention concerns prognostic markers associated with EGFR positive cancer. In particular, the invention concerns prognostic methods based on the molecular characterization of gene expression in paraffin-embedded, fixed tissue samples of EGFR-expressing cancer, which allow a physician to predict whether a patient is likely to respond well to treatment with an EGFR inhibitor.
摘要翻译： 本发明涉及与EGFR阳性癌症相关的预后标志物。 特别地，本发明涉及基于在石蜡包埋的EGFR表达癌症的固定组织样品中的基因表达的分子表征的预后方法，其允许医师预测患者是否可能对EGFR抑制剂的治疗反应良好 。
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