公开(公告)号：US06394605B1

公开(公告)日：2002-05-28

申请号：US09863561

申请日：2001-05-23

申请人： John A. Campin ,  Gary P. Gray ,  George H. Pettit

发明人： John A. Campin ,  Gary P. Gray ,  George H. Pettit

IPC分类号： A61B300

CPC分类号： A61B3/14

摘要： An automated focusing method for a wavefront sensor that iteratively determines the best optics setting for the wavefront sensor by making objective measurements of the patient's focus without the need for subjective information from the patient.

摘要翻译： 一种用于波前传感器的自动对焦方法，其通过对患者的焦点进行客观测量来迭代地确定波前传感器的最佳光学设置，而不需要来自患者的主观信息。

公开(公告)号：US08403919B2

公开(公告)日：2013-03-26

申请号：US11758425

申请日：2007-06-05

申请人： John A. Campin ,  George H. Pettit

发明人： John A. Campin ,  George H. Pettit

IPC分类号： A61B18/18

CPC分类号： A61F9/008 ,  A61B5/103 ,  A61F9/00804 ,  A61F2009/00859 ,  A61F2009/00872 ,  A61F2009/0088

摘要： A method for optimizing a prescription for laser-ablation corneal treatment includes receiving a measured correction prescription for a current patient. Next a database of treatment outcomes on a plurality of previously treated patients is accessed. The database contains a desired correction, and an actual correction. A difference between the desired correction and the actual correction represents an over- or undercorrection resulting from surgery. From the difference data is calculated a distribution of data points as a function of correction level. From the data-point distribution is calculated a statistically based offset applicable to the correction prescription for matching actual corrections with desired corrections. From the data-point distribution is calculated a confidence interval of the data using a predetermined confidence level. The statistically based offset is then adjusted based upon the confidence interval to provide an optimized prescription. The adjusted offset is then output for use in performing a refractive procedure.

摘要翻译： 用于优化激光消融角膜治疗处方的方法包括接收针对当前患者的测量的校正处方。 接下来，访问多个先前治疗的患者的治疗结果的数据库。 数据库包含所需的校正和实际校正。 所需矫正与实际矫正之间的差异代表手术引起的过度或欠矫。 根据差分数据计算数据点的分布作为校正水平的函数。 从数据点分布计算出适用于校正处方的统计学偏移量，用于将实际校正与期望的校正相匹配。 使用预定置信水平计算数据点分布的置信区间。 然后基于置信区间来调整基于统计学的偏移，以提供优化的处方。 然后输出经调整的偏移量以用于执行屈光程序。

公开(公告)号：US08945102B2

公开(公告)日：2015-02-03

申请号：US11491636

申请日：2006-07-24

申请人： Daniel S. Durrie ,  George H. Pettit ,  John A. Campin

发明人： Daniel S. Durrie ,  George H. Pettit ,  John A. Campin

IPC分类号： A61B18/20 ,  A61B19/00 ,  A61F9/008

CPC分类号： A61F9/00802 ,  A61F9/008 ,  A61F9/00806 ,  A61F9/00836 ,  A61F2009/00846 ,  A61F2009/00872 ,  A61F2009/0088

摘要： A method for performing wavefront-guided laser surgery on a cornea includes the step of calculating a corneal flap configuration based upon collected anatomical information on an eye and wavefront data on a cornea of the eye. Such data may be collected by, for example, an aberrometer, although this is not intended as a limitation. The calculated configuration is transmitted to a processor in controlling relation to a corneal flap-cutting device. The flap-cutting device is used to create a corneal flap based upon the calculated configuration. A system for performing wavefront-guided laser surgery on a cornea includes a processor for receiving the anatomical information and wavefront data. A software package is adapted to calculate the corneal flap configuration and to control a corneal flap-cutting device to cut a corneal flap commensurate with the calculated corneal flap configuration.

摘要翻译： 用于在角膜上进行波前引导激光手术的方法包括基于眼睛上收集的解剖信息和眼睛角膜上的波前数据计算角膜瓣构造的步骤。 这样的数据可以通过例如像差计来收集，尽管这不是作为限制。 所计算的配置在控制与角膜瓣切割装置的关系中被传送到处理器。 根据计算出的结构，使用襟翼切割装置创建角膜瓣。 用于在角膜上进行波前引导激光手术的系统包括用于接收解剖信息和波前数据的处理器。 软件包适用于计算角膜瓣构造并控制角膜瓣切割装置以切割与计算出的角膜瓣构造相称的角膜。

公开(公告)号：US07789513B2

公开(公告)日：2010-09-07

申请号：US12106439

申请日：2008-04-21

申请人： George H. Pettit ,  John A. Campin

发明人： George H. Pettit ,  John A. Campin

IPC分类号： A61B3/00 ,  A61B3/10

CPC分类号： A61B3/1015 ,  A61B3/1035 ,  A61B3/107 ,  A61F9/008 ,  A61F9/00806 ,  A61F2009/00859 ,  A61F2009/00872 ,  A61F2009/0088 ,  G06F19/00

摘要： A method for improving an accuracy of a prescription for laser-ablation corneal treatment includes the step of receiving a set of raw data comprising Hartmann-Shack image data obtained from a plurality of aberrometer measurements of a patient eye. The Hartmann-Shack data can include, for example, a dot pattern image for each measurement. A set of reconstructed wavefront data calculated from the set of raw data for the plurality of aberrometer measurements is also received. Data on a selected component of the set of raw data and in the set of reconstructed wavefront data are compared. If the selected component data differ more than a predetermined amount between the raw data and the reconstructed wavefront data, the raw data can be further manipulated prior to undertaking laser ablation. In addition, these data are removed from consideration for inclusion in the database of treatment outcomes.

摘要翻译： 用于提高激光消融角膜处理的处方精度的方法包括接收包括从患者眼睛的多个像差计测量获得的Hartmann-Shack图像数据的一组原始数据的步骤。 Hartmann-Shack数据可以包括例如每个测量的点图案图像。 还接收从多个像差计测量的原始数据集合计算出的一组重建波阵面数据。 比较原始数据集合和重建波阵面数据集中的选定分量上的数据。 如果所选择的分量数据在原始数据和重建的波前数据之间的预定量不同，则可以在进行激光烧蚀之前进一步操纵原始数据。 此外，这些数据从考虑中被删除，以纳入治疗结果数据库。

公开(公告)号：US20080306573A1

公开(公告)日：2008-12-11

申请号：US11758425

申请日：2007-06-05

申请人： John A. Campin ,  George H. Pettit

发明人： John A. Campin ,  George H. Pettit

IPC分类号： A61N5/067

CPC分类号： A61F9/008 ,  A61B5/103 ,  A61F9/00804 ,  A61F2009/00859 ,  A61F2009/00872 ,  A61F2009/0088

摘要： A method for optimizing a prescription for laser-ablation corneal treatment includes receiving a measured correction prescription for a current patient. Next a database of treatment outcomes on a plurality of previously treated patients is accessed. The database contains a desired correction, and an actual correction. A difference between the desired correction and the actual correction represents an over- or undercorrection resulting from surgery. From the difference data is calculated a distribution of data points as a function of correction level. From the data-point distribution is calculated a statistically based offset applicable to the correction prescription for matching actual corrections with desired corrections. From the data-point distribution is calculated a confidence interval of the data using a predetermined confidence level. The statistically based offset is then adjusted based upon the confidence interval to provide an optimized prescription. The adjusted offset is then output for use in performing a refractive procedure.

摘要翻译： 用于优化激光消融角膜治疗处方的方法包括接收针对当前患者的测量的校正处方。 接下来，访问多个先前治疗的患者的治疗结果的数据库。 数据库包含所需的校正和实际校正。 所需矫正与实际矫正之间的差异代表手术引起的过度或欠矫。 根据差分数据计算数据点的分布作为校正水平的函数。 从数据点分布计算出适用于校正处方的统计学偏移量，用于将实际校正与期望的校正相匹配。 使用预定置信水平计算数据点分布的置信区间。 然后基于置信区间来调整基于统计学的偏移，以提供优化的处方。 然后输出经调整的偏移量以用于执行屈光程序。

公开(公告)号：US20080259279A1

公开(公告)日：2008-10-23

申请号：US12106439

申请日：2008-04-21

申请人： George H. Pettit ,  John A. Campin

发明人： George H. Pettit ,  John A. Campin

IPC分类号： A61B3/10 ,  A61B3/028

CPC分类号： A61B3/1015 ,  A61B3/1035 ,  A61B3/107 ,  A61F9/008 ,  A61F9/00806 ,  A61F2009/00859 ,  A61F2009/00872 ,  A61F2009/0088 ,  G06F19/00

摘要： A method for improving an accuracy of a prescription for laser-ablation corneal treatment includes the step of receiving a set of raw data comprising Hartmann-Shack image data obtained from a plurality of aberrometer measurements of a patient eye. The Hartmann-Shack data can include, for example, a dot pattern image for each measurement. A set of reconstructed wavefront data calculated from the set of raw data for the plurality of aberrometer measurements is also received. Data on a selected component of the set of raw data and in the set of reconstructed wavefront data are compared. If the selected component data differ more than a predetermined amount between the raw data and the reconstructed wavefront data, the raw data can be further manipulated prior to undertaking laser ablation. In addition, these data are removed from consideration for inclusion in the database of treatment outcomes.

摘要翻译： 用于提高激光消融角膜处理的处方精度的方法包括接收包括从患者眼睛的多个像差计测量获得的Hartmann-Shack图像数据的一组原始数据的步骤。 Hartmann-Shack数据可以包括例如每个测量的点图案图像。 还接收从多个像差计测量的原始数据集合计算出的一组重建波阵面数据。 比较原始数据集合和重建波阵面数据集中的选定分量上的数据。 如果所选择的分量数据在原始数据和重建的波前数据之间的预定量不同，则可以在进行激光烧蚀之前进一步操纵原始数据。 此外，这些数据从考虑中被删除，以纳入治疗结果数据库。

公开(公告)号：US20080058778A1

公开(公告)日：2008-03-06

申请号：US11513648

申请日：2006-08-31

申请人： Kevin K. Liedel ,  George H. Pettit ,  John A. Campin

发明人： Kevin K. Liedel ,  George H. Pettit ,  John A. Campin

IPC分类号： A61B18/20

CPC分类号： A61F9/008 ,  A61F9/00814 ,  A61F2009/00872

摘要： A method for assessing a performance of an ablation laser system includes ablating a substrate surface to achieve a predetermined ablation pattern. A beam of light is directed across the ablated substrate, and reflected light is received to detect an actual ablated pattern, which is compared with the predetermined ablated pattern. The resulting comparison is displayed to a user so that the performance of the laser system can be assessed. A system includes a support that is adapted to hold an ablation substrate at a treatment plane. An optical scanner directs a beam of light across the ablated substrate and receives light reflected therefrom to detect an ablated pattern. An analyzer compares the detected with a predetermined ablated pattern. A display in signal communication with the analyzer displays a comparison of the detected and the predetermined ablated pattern.

摘要翻译： 用于评估消融激光系统的性能的方法包括烧蚀衬底表面以实现预定的消融图案。 光束被引导穿过烧蚀的衬底，并且接收反射光以检测与预定烧蚀图案相比较的实际烧蚀图案。 所得到的比较被显示给用户，使得可以评估激光系统的性能。 系统包括适于将消融衬底保持在处理平面处的支撑件。 光学扫描器将光束引导到烧蚀的衬底上并且接收从其反射的光以检测消融图案。 分析仪将检测到的与预定的烧蚀图案进行比较。 与分析器进行信号通信的显示器显示检测到的和预定的烧蚀图案的比较。

公开(公告)号：US07044944B2

公开(公告)日：2006-05-16

申请号：US10238919

申请日：2002-09-10

申请人： John Alfred Campin ,  George H. Pettit

发明人： John Alfred Campin ,  George H. Pettit

IPC分类号： A91B18/18

CPC分类号： A61B3/1015 ,  A61B5/103 ,  A61F9/00806 ,  A61F2009/00846 ,  A61F2009/00857 ,  A61F2009/00872 ,  A61F2009/0088

摘要： A system and method for converting measured wavefront data into an ablation profile for correcting visual defects includes providing measured wavefront data on an aberrated eye by a method such as known in the art. The measured wavefront data are correlated with accumulated data on previously treated eyes. Next an adjustment is applied to the measured wavefront data based upon the correlating step. This adjustment is used to form adjusted wavefront data for input to a wavefront data correction algorithm to calculate an ablation profile therefrom. The wavefront data correction algorithm may be modeled as, for example, Zernike polynomials with adjusted coefficients.

公开(公告)号：US06569154B2

公开(公告)日：2003-05-27

申请号：US09814398

申请日：2001-03-22

申请人： John Alfred Campin ,  George H. Pettit

发明人： John Alfred Campin ,  George H. Pettit

IPC分类号： A61B1700

CPC分类号： A61B3/1015 ,  A61B5/103 ,  A61F9/00804 ,  A61F9/00806 ,  A61F2009/00846 ,  A61F2009/00848 ,  A61F2009/00857 ,  A61F2009/00872 ,  A61F2009/0088

摘要： An optical correction system for correcting visual defects of an eye includes a wavefront analyzer responsive to a wavefront emanating from an eye for determining an optical path difference between a reference wave and the wavefront. A converter provides an optical correction based on the path difference and on a radially dependent ablation efficiency. The efficiency correction uses a compensating polynomial of the form A+B&rgr;+C&rgr;2+D&rgr;3+ . . . +X&rgr;n, where &rgr; is a normalized radius measured from a central portion of the cornea, reaching a value of 1 at an outer edge of the optical correction zone. A laser beam is directed to the cornea that has power sufficient for ablating corneal material. The optical correction is achieved by the removal of a selected amount of the corneal material to create a desired corneal shape change based on the optical correction.

摘要翻译： 用于校正眼睛的视觉缺陷的光学校正系统包括响应于从眼睛发出的波前的波前分析器，用于确定参考波和波前的光程差。 A转换器基于路径差和径向相关的消融效率提供光学校正。 效率校正使用形式为A + Brho + Crho2 + Drho3 +的补偿多项式。 。 。 + Xrhon，其中rho是从角膜的中心部分测量的归一化半径，在光学校正区域的外边缘处达到1。 激光束被引导到具有足以消融角膜材料的功率的角膜。 通过去除选定量的角膜材料以基于光学校正产生期望的角膜形状变化来实现光学校正。

公开(公告)号：US20110245919A1

公开(公告)日：2011-10-06

申请号：US13075239

申请日：2011-03-30

申请人： George H. Pettit

发明人： George H. Pettit

IPC分类号： A61F2/16

CPC分类号： A61F2/1613 ,  A61F2/1627 ,  A61F2/1659 ,  A61F2002/16965

摘要： The present invention is related to an adjustable intraocular lens system comprised of a lens body having an adjustable refractive index and a shield for protecting the lens body from degradation that might otherwise be caused by exposure to particular electromagnetic radiation. More preferably, the present invention is directed to an adjustable intraocular lens system comprised of a lens body and a shield wherein the lens body is formed of a material with a refractive index that can be adjusted by exposure to adjusting electromagnetic radiation (e.g., multiple photon energy) and wherein the shield protects the lens body from degradation that might otherwise be caused by exposure to degrading electromagnetic radiation such as ultraviolet radiation.

摘要翻译： 本发明涉及一种可调节眼内透镜系统，其包括具有可调节折射率的透镜体和用于保护透镜体免受另外可能由于暴露于特定电磁辐射引起的退化的屏蔽。 更优选地，本发明涉及一种由透镜体和屏蔽体组成的可调节眼内透镜系统，其中透镜体由具有可通过调节电磁辐射照射而调节的折射率的材料形成（例如，多个光子 能量），并且其中屏蔽件保护透镜体免受另外可能由于暴露于诸如紫外线辐射的降解电磁辐射而引起的劣化。