公开(公告)号：US20180099059A1

公开(公告)日：2018-04-12

申请号：US15729164

申请日：2017-10-10

申请人： John A. Hossack ,  Adam Joseph Dixon ,  Edwin Lu

发明人： John A. Hossack ,  Adam Joseph Dixon ,  Edwin Lu

IPC分类号： A61K49/22

CPC分类号： A61K49/223 ,  A61K49/225 ,  A61K49/227

摘要： A composition for cell tracking and molecular imaging containing perfluorocarbon (“PFC”) droplets having a liquid PFC core enclosed within a stabilizing shell and embedded with solid nanoparticles. The solid nanoparticles act as nucleating agents for reducing the activation pressure of the liquid PFC core required to transition the liquid PFC core to a gaseous microbubble thereby permitting the use of more body-temperature stable longer chain PFCs in the liquid PFC core. The improved stability of the PFC droplets with a reduced or limited increase in the activation pressure required due to the nucleating nanoparticles improves the efficacy of using the PFC droplets as phase-change contrast agents.

公开(公告)号：US10368834B2

公开(公告)日：2019-08-06

申请号：US14113672

申请日：2012-04-25

申请人： F. William Mauldin, Jr. ,  John A. Hossack ,  Kevin Owen

发明人： F. William Mauldin, Jr. ,  John A. Hossack ,  Kevin Owen

IPC分类号： A61B8/08 ,  A61B8/00 ,  G01S7/52 ,  G01S15/60 ,  G01S15/89 ,  A61B34/20 ,  A61B17/34 ,  A61B90/00

摘要： An ultrasonic transducer element can configured to generate ultrasonic energy directed into tissue of a subject and configured to receive a portion of the ultrasonic energy reflected by a target located within the tissue. The ultrasonic transducer can include a surface configured to provide or receive the ultrasonic energy, the surface including an area of greater than or equal to about 4λ2, or the ultrasonic transducer element can be included in an array having a spacing between at least two adjacent ultrasound elements of less than or equal to about ½λ, and the array comprising an aperture that is at least approximately symmetrical in two axes. A three-dimensional representation of one or more of a location, shape, or orientation of at least a portion of the target can be presented via the display.

公开(公告)号：US20100168578A1

公开(公告)日：2010-07-01

申请号：US12664146

申请日：2008-06-12

申请人： Arthur Garson, JR. ,  William F. Walker ,  John A. Hossack ,  Travis N. Blalock

发明人： Arthur Garson, JR. ,  William F. Walker ,  John A. Hossack ,  Travis N. Blalock

IPC分类号： A61B8/14 ,  A61B5/0402

CPC分类号： A61B8/0858 ,  A61B8/0883 ,  A61B8/483

摘要： A system and related method for obtaining volumetric cardiac data of a subject. The data is generated by forming a plurality of focused ultrasound images corresponding to a series of ranges, generating myocardial boundary data for each of the plurality of ultrasound images, calculating the area of the region defined by said myocardial boundary data for each of the plurality of ultrasound images, multiplying the area for each of the plurality of ultrasound images by a slice depth corresponding to said ultrasound image to obtain the slice volume of each slice, and summing the slice volumes to obtain a total volume. In an alternative embodiment the system and related method combine an automated volumetric ultrasound system for finding chamber volumes and myocardial thicknesses, with a diagnostic electrocardiogram system to enable simultaneous diagnosis of mechanical and electrical cardiac problems.

摘要翻译： 用于获得受试者体积心脏数据的系统和相关方法。 通过形成对应于一系列范围的多个聚焦超声图像来生成数据，为多个超声图像中的每一个生成心肌边界数据，计算由多个超声图像中的每一个的所述心肌边界数据定义的区域的面积 超声图像，将所述多个超声图像中的每一个的面积乘以对应于所述超声图像的切片深度，以获得每个切片的切片体积，并且对切片体积求和以获得总体积。 在替代实施例中，系统和相关方法结合了用于发现腔室体积和心肌厚度的自动化体积超声系统与诊断心电图系统，以实现机电和电心脏问题的同时诊断。

公开(公告)号：US06780152B2

公开(公告)日：2004-08-24

申请号：US10180386

申请日：2002-06-26

申请人： Kutay F. Üstüner ,  Thilaka S. Sumanaweera ,  Sevig Ayter ,  Kenneth M. Fowkes ,  John A. Hossack ,  John W. Allison

发明人： Kutay F. Üstüner ,  Thilaka S. Sumanaweera ,  Sevig Ayter ,  Kenneth M. Fowkes ,  John A. Hossack ,  John W. Allison

IPC分类号： A61B800

CPC分类号： A61B8/5284 ,  A61B8/08 ,  A61B8/0883 ,  A61B8/4245 ,  A61B8/483 ,  G01S7/52074 ,  G01S15/8993 ,  G01S15/8995

摘要： Images of the heart are formed by using multiple sets of ultrasound data. Each set of data is acquired and processed responsive to a different set of imaging parameters. The imaging parameter sets differ in at least one parameter, such as array position, temporal frequency response or transmit focal depth, so that the images formed using these data sets have, either laterally or axially, different spatial spectra. A set of images is formed responsive to a first imaging parameter set for a first cardiac cycle. Another set of images is formed responsive to a second imaging parameter set for a second cardiac cycle. The two sets of images are temporally aligned so that they correspond to the same set of phases of the cardiac cycle. Since the data acquisition and processing are distributed over multiple cycles of the motion, assuming regular periodic heart cycle, temporal resolution is maintained.

摘要翻译： 通过使用多组超声数据形成心脏的图像。 响应于不同的成像参数集，获取和处理每组数据。 成像参数集在至少一个参数（例如阵列位置，时间频率响应或发射焦深）上不同，使得使用这些数据集形成的图像具有横向或轴向不同的空间光谱。 响应于为第一心动周期设置的第一成像参数形成一组图像。 响应于为第二心动周期设置的第二成像参数形成另一组图像。 这两组图像在时间上对准，使得它们对应于心动周期的相同的一组相位。 由于数据采集和处理分布在运动的多个周期上，假设定期周期性的心脏周期，维持时间分辨率。

公开(公告)号：US06755787B2

公开(公告)日：2004-06-29

申请号：US10299179

申请日：2002-11-19

申请人： John A. Hossack ,  Jeffrey S. Hastings ,  Jeffrey M. Greenberg ,  Samuel H. Maslak

发明人： John A. Hossack ,  Jeffrey S. Hastings ,  Jeffrey M. Greenberg ,  Samuel H. Maslak

IPC分类号： A61B800

CPC分类号： G01S15/899 ,  A61B8/483 ,  A61B8/5276 ,  G01S7/52034 ,  G01S7/52077 ,  G01S15/8981 ,  G01S15/8993 ,  G01S15/8995

摘要： A method and system for reducing speckle for two and three-dimensional images is disclosed. For two-dimensional imaging, a one and a half or a two-dimensional transducer is used to obtain sequential, parallel or related frames of elevation spaced data. The frames are compounded to derive a two-dimensional image. For three-dimensional imaging, various pluralities of two-dimensional frames of data spaced in elevation are compounded into one plurality of spaced two-dimensional frames of data. The frames of data are then used to derive a three dimensional set of data, such as by interpolation. Alternatively, the various pluralities are used to derive a three-dimensional set of data. An anisotropic filter is applied to the set of data. The anisotropic filter filters at least along the elevation dimension. In either situation, various displays may be generated from the final three-dimensional set of data. A method and system for adjustably generating two and three-dimensional representations is also disclosed. For three-dimensional imaging, at least two sets of three-dimensional data corresponding respectively to two types of Doppler or B-mode data are generated. The sets of data are then combined. An image or a quantity may be obtained from the combined data. By combining after generating the three-dimensional sets of data, the same data (sets of data) may be combined multiple times pursuant to different relationships. Thus, a user may optimize the image or quantity. Likewise, frames of data may be combined pursuant to different persistence parameters, such as different finite impulse response filter size and coefficients. The frames of data may then be re-combined pursuant to different persistence parameters. Original ultrasound data may also be used to re-generate an imaging using the same ultrasound image processes as used for a previous image. APPENDIX A ⁢ Filter at Plane ⁢ Y = - 2   ⁢ X ⁢   ⁢ → ⁢ [ 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 ] ⁢ Z ↓ Filter at Plane ⁢ Y = - 1 ⁢ [ 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 ] Filter at Plane ⁢ Y = 0 ⁢ [ 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 ] Filter at Plane ⁢ Y = + 1 ⁢ [ 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 ] Filter at Plane ⁢ Y = + 2 ⁢ [ 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 ] The filter perform no filtering in the X, Z plane. It filters (low pass) contributions from neighboring elements in only the Y direction. The filter may be implemented as a 1-D low pass filter in the Y-direction [0.2, 0.4, 1.0, 0.4, 0.2]=(a 1×5×1 anisotropic filter).

公开(公告)号：US06679846B2

公开(公告)日：2004-01-20

申请号：US10081978

申请日：2002-02-21

申请人： David J. Napolitano ,  Christopher R. Cole ,  Gregory L. Holley ,  John A. Hossack ,  Charles E. Bradley ,  Patrick Phillips

发明人： David J. Napolitano ,  Christopher R. Cole ,  Gregory L. Holley ,  John A. Hossack ,  Charles E. Bradley ,  Patrick Phillips

IPC分类号： B60R2500

CPC分类号： G01S15/8963 ,  A61B8/00 ,  G01S7/52039 ,  G01S7/52046 ,  G01S7/52085 ,  G01S7/52095 ,  G01S15/8927 ,  G01S15/8959 ,  G01S15/8977

摘要： A medical diagnostic ultrasonic imaging system acquires receive beams from spatially distinct transmit beams. The receive beams alternate in type between at least first and second types across the region being imaged. The first and second types of receive beams differ in at least one scan parameter other than transmit and receive line geometry, and can for example differ in transmit phase, transmit or receive aperture, system frequency, transmit focus, complex phase angle, transmit code or transmit gain. Receive beams associated with spatially distinct ones of the transmit beams (including at least one beam of the first type and at least one beam of the second type) are then combined. In this way, many two-pulse techniques, including, for example, phase inversion techniques, synthetic aperture techniques, synthetic frequency techniques, and synthetic focus techniques, can be used while substantially reducing the frame rate penalty normally associated with such techniques.

公开(公告)号：US06517488B1

公开(公告)日：2003-02-11

申请号：US09606515

申请日：2000-06-29

申请人： John A. Hossack

发明人： John A. Hossack

IPC分类号： A61B806

CPC分类号： G01S15/8981 ,  A61B8/06 ,  G01S15/584 ,  G01S15/8993 ,  Y10S128/916

摘要： A method and system for identifying constrictions in a vessel are provided. Total blood volume flow is measured at various locations along the vessel. The total volume flow must be conserved. Regions with a different volume flow than expected (e.g. areas associated with a lower volume that violates conservation of flow) are identified as suspicious. Suspicious regions are likely associated with dropout artifact. Actual constrictions are determined from the geometry of images where the region is not suspicious.

摘要翻译： 提供了用于识别容器中的收缩部的方法和系统。 在血管的不同位置测量总体积血流量。 总体积流量必须保守。 具有不同于预期的体积流量的区域（例如，与较低体积相关的区域违反流动的保护）被识别为可疑的。 可疑地区可能与辍学神器有关。 实际收缩是根据区域不可疑的图像几何确定的。

公开(公告)号：US06461299B1

公开(公告)日：2002-10-08

申请号：US09469994

申请日：1999-12-22

申请人： John A. Hossack

发明人： John A. Hossack

IPC分类号： A61B800

CPC分类号： G01S15/895 ,  B06B1/0215 ,  B06B2201/20 ,  B06B2201/51 ,  B06B2201/76 ,  G01S7/52017 ,  G01S7/52025 ,  G01S7/52034

摘要： A method and system for generating transmit pulses for use with an electrostatic transducer in harmonic imaging are provided. The excitation waveforms are pre-distorted to account for the non-linear output of the electrostatic transducer. Additionally, the force on a multiple element electrostatic transducer array is measured. A bias voltage is applied to the electrostatic transducer where the bias voltage is responsive to the measured force.

摘要翻译： 提供了一种用于产生用于谐波成像中的静电换能器的发射脉冲的方法和系统。 励磁波形是预失真的，以解决静电换能器的非线性输出。 另外，测量多元素静电换能器阵列上的力。 偏置电压施加到静电换能器，其中偏置电压响应于测量的力。

公开(公告)号：US06371913B2

公开(公告)日：2002-04-16

申请号：US09733131

申请日：2000-12-08

申请人： Linyong Pang ,  John A. Hossack ,  Ismayil Guracar

发明人： Linyong Pang ,  John A. Hossack ,  Ismayil Guracar

IPC分类号： A61B800

CPC分类号： G01S15/8988 ,  G01S7/52065 ,  G01S7/52066 ,  G01S7/52071 ,  G01S7/52074 ,  G01S15/8979 ,  G01S15/8993 ,  G06F19/00 ,  G06F19/321 ,  G06T7/20 ,  G16H50/50

摘要： An medical diagnostic ultrasonic image processing method estimates motion between first and second composite ultrasonic images that include both B-mode and Color Doppler information. First and second B-mode images are extracted from the first and second composite ultrasonic images, respectively, and then motion is estimated between the first and second B-mode images. The estimated motion is then used to compose a multi-frame image using at least portions of the composite ultrasonic images or derivatives of the composite ultrasonic images, such as the B-mode images.

摘要翻译： 医学诊断超声波图像处理方法估计包括B模式和彩色多普勒信息的第一和第二复合超声波图像之间的运动。 从第一和第二复合超声波图像分别提取第一和第二B模式图像，然后在第一和第二B模式图像之间估计运动。 然后，使用至少部分复合超声波图像或复合超声波图像的导数（例如B模式图像）来使用估计运动来组合多帧图像。

公开(公告)号：US06338716B1

公开(公告)日：2002-01-15

申请号：US09448129

申请日：1999-11-24

申请人： John A. Hossack ,  Douglas J. Gallinat ,  Timothy E. Petersen ,  Joseph J. Molinari ,  Sean C. Little

发明人： John A. Hossack ,  Douglas J. Gallinat ,  Timothy E. Petersen ,  Joseph J. Molinari ,  Sean C. Little

IPC分类号： A61B800

CPC分类号： A61B8/4438 ,  A61B8/0833 ,  A61B8/4254 ,  G01S7/5208 ,  G01S15/899

摘要： The preferred embodiments described herein provide a medical diagnostic ultrasonic transducer probe and imaging system for use with a position and orientation sensor. In one preferred embodiment, an ultrasonic transducer probe comprises a position and orientation sensor and a memory device comprising calibration data for the position and orientation sensor. The memory device is adapted to provide the calibration data to a medical diagnostic ultrasound imaging system coupled with the ultrasonic transducer probe. In another preferred embodiment, a medical diagnostic ultrasound imaging system comprises a memory device comprising a plurality of position and orientation sensor calibration data. Each of the plurality of position and orientation sensor calibration data is associated with a respective ultrasonic transducer probe family. In operation, identification of a probe family of an ultrasonic transducer probe is provided to the ultrasound system. The ultrasound system then selects the position and orientation sensor calibration data corresponding to the identified probe family.

摘要翻译： 本文所述的优选实施例提供了一种用于与位置和方向传感器一起使用的医疗诊断超声换能器探针和成像系统。 在一个优选实施例中，超声换能器探头包括位置和方位传感器以及包括位置和方位传感器的校准数据的存储器件。 存储器装置适于将校准数据提供给与超声波换能器探头耦合的医疗诊断超声成像系统。 在另一个优选实施例中，医疗诊断超声成像系统包括包括多个位置和方向传感器校准数据的存储器件。 多个位置和方向传感器校准数据中的每一个与相应的超声换能器探头系列相关联。 在操作中，将超声波换能器探针的探针系列的识别提供给超声系统。 然后，超声系统选择对应于所识别的探针系列的位置和方向传感器校准数据。