公开(公告)号：US6125294A

公开(公告)日：2000-09-26

申请号：US907112

申请日：1997-08-06

申请人： John Anthony Scholl ,  Thomas A. Silvestrini ,  Isidro Matias Gandionco ,  William P. Kuhn ,  Phillip C. Baker

发明人： John Anthony Scholl ,  Thomas A. Silvestrini ,  Isidro Matias Gandionco ,  William P. Kuhn ,  Phillip C. Baker

IPC分类号： A61B3/10 ,  A61B8/10 ,  A61B19/00 ,  A61F9/007 ,  A61F9/013 ,  A61B5/00

CPC分类号： A61F9/0133 ,  A61B8/10 ,  A61B90/06 ,  A61B2090/062 ,  A61F9/013

摘要： A method and apparatus for performing a surgical procedure on a patient is described. An incision is made into tissue of the patient to create a tissue pocket. The tissue has an anterior surface. Preferably, the tissue is corneal tissue of an eye. A reflective element is inserted into the pocket. An energy source generates a radiant energy signal, which is directed toward the reflective element. Reflected energy is received from the reflective element. A detector determines the depth of the reflective element below the anterior surface based upon the energy reflected by the reflective element. The speed of transmission of the radiant energy in the reflective element is different (preferably slower) than the speed of transmission of the radiant energy in the tissue. The reflective element may be in the form of a tool on which is disposed a biocompatible polymer layer, the layer comprising trapped air spaces, or a tool having an open space for containing trapped air. The radiant energy may take the form of ultrasound generated by an ultrasonic probe, or light generated by a confocal microscope. The confocal microscope may employ longitudinal chromatic aberration to measure the depth of the reflective element. When employing a confocal microscope, the depth of the reflective element is a function of the reflected energy from the anterior surface and the reflected energy from the reflective element.

摘要翻译： 描述了一种用于对患者进行外科手术的方法和装置。 将切口制成患者的组织以产生组织袋。 组织具有前表面。 优选地，组织是眼睛的角膜组织。 将反射元件插入口袋中。 能量源产生朝向反射元件的辐射能信号。 从反射元件接收反射能量。 检测器基于由反射元件反射的能量确定反射元件在前表面下方的深度。 反射元件中的辐射能的传输速度与组织中的辐射能的传递速度不同（优选地较慢）。 反射元件可以是工具的形式，其上设置有生物相容性聚合物层，该层包括被捕获的空气空间，或具有用于容纳被捕获的空气的开放空间的工具。 辐射能可以采用由超声波探头产生的超声或由共聚焦显微镜产生的光的形式。 共焦显微镜可以采用纵向色差来测量反射元件的深度。 当使用共焦显微镜时，反射元件的深度是来自前表面的反射能量和来自反射元件的反射能量的函数。

公开(公告)号：US06175754B1

公开(公告)日：2001-01-16

申请号：US08476462

申请日：1995-06-07

申请人： John Anthony Scholl ,  Thomas A. Silvestrini ,  Isidro Matias Gandionco ,  William P. Kuhn ,  Phillip C. Baker

发明人： John Anthony Scholl ,  Thomas A. Silvestrini ,  Isidro Matias Gandionco ,  William P. Kuhn ,  Phillip C. Baker

IPC分类号： A61B1700

CPC分类号： A61F9/0133 ,  A61B8/10 ,  A61B90/06 ,  A61F9/013

摘要： A method and apparatus for performing a surgical procedure on a patient is described. An incision is made into tissue of the patient to create a tissue pocket. The tissue has an anterior surface. Preferably, the tissue is corneal tissue of an eye. A reflective element is inserted into the pocket. An energy source generates a radiant energy signal, which is directed toward the reflective element. Reflected energy is received from the reflective element. A detector determines the depth of the reflective element below the anterior surface based upon the energy reflected by the reflective element. The speed of transmission of the radiant energy in the reflective element is different (preferably slower) than the speed of transmission of the radiant energy in the tissue. The reflective element may be in the form of a tool on which is disposed a biocompatible polymer layer, the layer comprising trapped air spaces, or a tool having an open space for containing trapped air. The radiant energy may take the form of ultrasound generated by an ultrasonic probe, or light generated by a confocal microscope. The confocal microscope may employ longitudinal chromatic aberration to measure the depth of the reflective element. When employing a confocal microscope, the depth of the reflective element is a function of the reflected energy from the anterior surface and the reflected energy from the reflective element.

摘要翻译： 描述了一种用于对患者进行外科手术的方法和装置。 将切口制成患者的组织以产生组织袋。 组织具有前表面。 优选地，组织是眼睛的角膜组织。 将反射元件插入口袋中。 能量源产生朝向反射元件的辐射能信号。 从反射元件接收反射能量。 检测器基于由反射元件反射的能量确定反射元件在前表面下方的深度。 反射元件中的辐射能的传输速度与组织中的辐射能的传递速度不同（优选地较慢）。 反射元件可以是工具的形式，其上设置有生物相容性聚合物层，该层包括被捕获的空气空间，或具有用于容纳被捕获的空气的开放空间的工具。 辐射能可以采用由超声波探头产生的超声或由共聚焦显微镜产生的光的形式。 共焦显微镜可以采用纵向色差来测量反射元件的深度。 当使用共焦显微镜时，反射元件的深度是来自前表面的反射能量和来自反射元件的反射能量的函数。

公开(公告)号：US09943401B2

公开(公告)日：2018-04-17

申请号：US12384659

申请日：2009-04-06

申请人： Eugene de Juan, Jr. ,  Cary J. Reich ,  Stephen Boyd ,  Yair Alster ,  David Sierra ,  Hanson S. Gifford ,  Jose D. Alejandro ,  Richard L. Lindstrom ,  K. Angela Macfarlane ,  Douglas Sutton ,  John Anthony Scholl

发明人： Eugene de Juan, Jr. ,  Cary J. Reich ,  Stephen Boyd ,  Yair Alster ,  David Sierra ,  Hanson S. Gifford ,  Jose D. Alejandro ,  Richard L. Lindstrom ,  K. Angela Macfarlane ,  Douglas Sutton ,  John Anthony Scholl

IPC分类号： A61F2/14 ,  A61F9/00 ,  G02C7/04

CPC分类号： A61F2/142 ,  A61F2/14 ,  A61F9/00 ,  A61F2250/0067 ,  G02C7/047

摘要： A therapeutic lens for the treatment of an epithelial defect comprises a layer of therapeutic material disposed over the stroma and/or Bowman's membrane to inhibit water flow from the tear liquid to the stroma and/or Bowman's membrane, such that corneal deturgescence can be restored to decrease corneal swelling and light scattering. The layer may cover and protect nerve fibers to decrease pain. The layer may comprise an index of refraction to inhibit light scatter from an anterior surface of the stroma and/or Bowman's membrane. The lens may comprise a curved anterior surface that provides functional vision for the patient when the epithelium regenerates. The layer of therapeutic material can be positioned on the eye in many ways, for example with a spray that is cured to adhere the layer to the exposed surface of the stroma and/or Bowman's membrane.