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    INTRAOCULAR ACCOMMODATING LENS AND METHODS OF USE
    3.
    发明申请
    INTRAOCULAR ACCOMMODATING LENS AND METHODS OF USE 审中-公开
    内窥镜镜片和使用方法

    公开(公告)号：US20120253459A1

    公开(公告)日：2012-10-04

    申请号：US13366165

    申请日：2012-02-03

    申请人： Cary Reich ,  Eugene de Juan, JR. ,  Yair Alster

    发明人： Cary Reich ,  Eugene de Juan, JR. ,  Yair Alster

    IPC分类号： A61F2/16

    CPC分类号： A61F2/1624 ,  A61F2/1602 ,  A61F2/1635 ,  A61F2/1648 ,  A61F2002/1682 ,  A61F2250/0018 ,  F04C2270/041

    摘要： Described herein are intraocular lenses and methods of implantation. In one aspect, the lens includes a shape changing optical element; a force translation element having a first end region coupled to the optical element and a second end region extending towards a ciliary structure, and an attachment portion coupled to the second end region of the force translation element and configured to contact the ciliary structure. The force translation element is configured to functionally transmit movements of the ciliary structure into a force exerted upon the optical element to effect an accommodating and a disaccommodating change of the optical element.

    摘要翻译： 本文描述的是眼内透镜和植入方法。 一方面，透镜包括形状变化光学元件; 力平移元件，其具有联接到所述光学元件的第一端部区域和朝向睫状结构延伸的第二端部区域，以及连接到所述力平移元件的所述第二端部区域并被配置为接触所述睫状结构的附接部分。 力平移元件构造成功能地将睫状结构的运动传递到施加在光学元件上的力，以实现光学元件的容纳和不适应的变化。

    Posterior Segment Drug Delivery
    5.
    发明申请
    Posterior Segment Drug Delivery 有权
    后期药物递送

    公开(公告)号：US20100255061A1

    公开(公告)日：2010-10-07

    申请号：US12696678

    申请日：2010-01-29

    申请人： Eugene de Juan, JR. ,  Yair Alster ,  Steven M. Chamow ,  Kathleen Cogan Farinas ,  Hanson S. Gifford, III ,  K. Angela MacFarlane ,  Cary J. Reich ,  Michael Barrett ,  Randolph E. Campbell ,  Robert George ,  Douglas Sutton

    发明人： Eugene de Juan, JR. ,  Yair Alster ,  Steven M. Chamow ,  Kathleen Cogan Farinas ,  Hanson S. Gifford, III ,  K. Angela MacFarlane ,  Cary J. Reich ,  Michael Barrett ,  Randolph E. Campbell ,  Robert George ,  Douglas Sutton

    IPC分类号： A61F9/00 ,  A61K39/395 ,  A61P27/02 ,  A61K31/5575 ,  A61K31/58 ,  A61F2/14 ,  B23P17/04

    CPC分类号： G01N33/558 ,  A61F9/0017 ,  A61K9/0048 ,  A61K9/0051 ,  A61K31/57 ,  A61K31/573 ,  A61K31/58 ,  A61K38/385 ,  A61K47/32 ,  A61K47/34 ,  A61K47/38 ,  A61K2039/505 ,  C07K16/22 ,  C07K2317/24 ,  C07K2317/55 ,  Y10T29/49826

    摘要： A therapeutic device to release a therapeutic agent comprises a porous structure coupled to a container comprising a reservoir. The reservoir comprises a volume sized to release therapeutic amounts of the therapeutic agent for an extended time when coupled to the porous structure and implanted in the patient. The porous structure may comprise a first side coupled to the reservoir and a second side to couple to the patient to release the therapeutic agent. A plurality of interconnecting channels can extend from the first side to the second side so as to connect a first a plurality of openings on the first side with a second plurality of openings on the second side. Each of the openings on the first side can be connected to each of the openings on the second side with the plurality of interconnecting channels, such that the rate of release of the therapeutic agent can be substantially maintained when one or more of the openings is blocked, for example with particles, cells, bacteria or tissue when the device is implanted for an extended time. The length of the channels extending from the first side to the second side may comprise an effective length greater than a distance across the porous structure from the first side to the second side. The therapeutic device many comprise an expandable retention structure and an expandable reservoir, such that the device can be delivered from a lumen of a delivery device and expand when positioned in the patient. The therapeutic device may comprises a penetrable barrier to inject therapeutic agent into the device when implanted in the patient.

    摘要翻译： 用于释放治疗剂的治疗装置包括联接到包括储存器的容器的多孔结构。 储存器包括体积大小，当耦合到多孔结构并且植入患者体内时，释放治疗剂量的治疗剂延长的时间。 所述多孔结构可以包括联接到所述储存器的第一侧和与所述患者联接以释放所述治疗剂的第二侧。 多个互连通道可以从第一侧延伸到第二侧，以便将第一侧上的第一多个开口与第二侧上的第二多个开口连接。 第一侧的每个开口可以与多个互连通道连接到第二侧的每个开口，使得当一个或多个开口被阻塞时可以基本上保持治疗剂的释放速度 ，例如当器件长时间植入时，可以使用颗粒，细胞，细菌或组织。 从第一侧延伸到第二侧的通道的长度可以包括大于多孔结构从第一侧到第二侧的距离的有效长度。 治疗装置许多包括可扩张的保留结构和可扩张的储存器，使得该装置可以从输送装置的内腔输送，并且在定位在患者体内时膨胀。 治疗装置可以包括当植入患者时将治疗剂注入装置中的可穿透屏障。

    Ocular insert apparatus and methods
    9.
    发明授权
    Ocular insert apparatus and methods 有权
    眼插装置和方法

    公开(公告)号：US08715712B2

    公开(公告)日：2014-05-06

    申请号：US13688019

    申请日：2012-11-28

    申请人： Eugene de Juan, Jr. ,  Yair Alster ,  Cary J. Reich ,  K. Angela MacFarlane ,  Janelle Chang ,  Jose D. Alejandro

    发明人： Eugene de Juan, Jr. ,  Yair Alster ,  Cary J. Reich ,  K. Angela MacFarlane ,  Janelle Chang ,  Jose D. Alejandro

    IPC分类号： A61F2/00

    CPC分类号： A61F9/0017 ,  A61B17/00234 ,  A61K9/0051 ,  A61K47/34 ,  A61L27/025 ,  A61L27/16

    摘要： A comfortable insert comprises a retention structure sized for placement under the eyelids and along at least a portion of conjunctival sac of the upper and lower lids of the eye. The retention structure resists deflection when placed in the conjunctival sac of the eye and to guide the insert along the sac when the eye moves. The retention structure can be configured in many ways to provide the resistance to deflection and may comprise a hoop strength so as to urge the retention structure outward and inhibit movement of the retention structure toward the cornea. The insert may move rotationally with deflection along the conjunctival sac, and may comprise a retention structure having a cross sectional dimension sized to fit within folds of the conjunctiva. The insert may comprise a release mechanism and therapeutic agent to release therapeutic amounts of the therapeutic agent for an extended time.

    摘要翻译： 舒适的插入物包括保持结构，其尺寸适于放置在眼睑下方并且沿着眼睛的上盖和下盖的结膜囊的至少一部分。 保留结构在放置在眼结膜囊中时抵抗偏转，并且当眼睛移动时沿着囊引导插入物。 保持结构可以以许多方式构造以提供对偏转的抵抗力，并且可以包括环箍强度，以便向外推动保持结构并阻止保持结构朝向角膜的移动。 插入件可以沿着结膜囊的偏转而旋转移动，并且可以包括保持结构，该保持结构具有尺寸适合于结膜折叠的横截面尺寸。 插入物可以包含释放机制和治疗剂以释放长期治疗剂的治疗剂量。

    SUBCONJUCTIVAL IMPLANT FOR POSTERIOR SEGMENT DRUG DELIVERY
    10.
    发明申请
    SUBCONJUCTIVAL IMPLANT FOR POSTERIOR SEGMENT DRUG DELIVERY 审中-公开
    用于分支部门药物递送的分支植入物

    公开(公告)号：US20130274692A1

    公开(公告)日：2013-10-17

    申请号：US13814470

    申请日：2011-08-04

    申请人： Yair Alster ,  Eugene De Juan, JR. ,  Kathleen Cogan Farinas ,  K. Angela MacFarlane ,  Cary J. Reich ,  Randolph E. Campbell ,  Signe Erickson

    发明人： Yair Alster ,  Eugene De Juan, JR. ,  Kathleen Cogan Farinas ,  K. Angela MacFarlane ,  Cary J. Reich ,  Randolph E. Campbell ,  Signe Erickson

    IPC分类号： A61F9/00

    CPC分类号： A61F9/0017 ,  A61K9/0051 ,  A61K31/00 ,  A61K31/573 ,  A61K31/58

    摘要： A therapeutic device can be configured to place the reservoir substantially between the conjunctiva and the scleral such that the size of the reservoir can be increased and the size of the scleral penetration decreased so as to decrease invasiveness. The device may comprise a substantially constant reservoir volume and drug release mechanism, in which the volume of the reservoir and mechanism are tuned to receive a quantity of therapeutic agent with a volume of injected formulation and release the therapeutic agent for an extended time with a release rate profile. The porous structure may comprise a first side coupled to the reservoir and a second side to couple to the patient to release the therapeutic agent, and a plurality of interconnecting channels can extend from the first side to the second side.

    摘要翻译： 治疗装置可以被配置为将储存器基本上放置在结膜和巩膜之间，使得储存器的尺寸可以增加并且巩膜穿透的尺寸减小以降低侵入性。 该装置可以包括基本上恒定的储存器体积和药物释放机构，其中储存器和机构的体积被调谐以接收一定量的具有注射制剂体积的治疗剂，并释放治疗剂延长的时间 费率简介。 多孔结构可以包括联接到储存器的第一侧和耦合到患者以释放治疗剂的第二侧，并且多个互连通道可以从第一侧延伸到第二侧。