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公开(公告)号：US5047040A
公开(公告)日：1991-09-10
申请号：US312108
申请日：1989-02-16
IPC分类号： A61B17/22
CPC分类号： A61B17/3207 , A61B17/320758 , A61B2017/320064
摘要： An atherectomy device for removing stenosis materials from a vascular vessel is provided. The atherectomy device includes a flexible tubular member, a flexible drive means disposed within the tubular member, and a cutting assembly carried by the distal extremity of the tubular member. The cutting assembly includes a collection chamber which receives a cutting bit carried by the drive means. The cutting bit is rotated to remove materials from the stenosis and cause the removed materials to be withdrawn into the collection chamber as the bit is advanced. A second embodiment of the atherectomy device includes an anchor member coaxially mounted within a tubular cutting blade at the distal end of the catheter. The anchor member is first advanced into a region of stenosis where it becomes embedded, and the tubular blade is subsequently advanced over the anchor member to sever the stenosis. The tubular blade and anchor member may be retracted within the catheter and thus used to withdraw the several material from the blood vessel.
摘要翻译： 提供了一种用于从血管容器中移除狭窄物质的粥样斑块切除装置。 粥样斑块切除装置包括柔性管状构件，设置在管状构件内的柔性驱动装置和由管状构件的远端支承的切割组件。 切割组件包括收集室，该收集室容纳由驱动装置承载的切割钻头。 旋转切削刀头以从狭窄中移除材料，并且使得被移除的材料在钻头前进时被抽出到收集腔中。 粥样斑块切除装置的第二实施例包括同轴地安装在导管远端的管状切割刀片内的锚定构件。 锚固构件首先进入狭窄区域，在其中嵌入，并且管状刀片随后在锚固构件上前进以切断狭窄。 管状刀片和锚定构件可以缩回到导管内，并且因此用于从血管中抽出多种材料。
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公开(公告)号：US5053044A
公开(公告)日：1991-10-01
申请号：US142382
申请日：1988-01-11
IPC分类号： A61B17/22
CPC分类号： A61B17/320725 , A61B17/3209 , A61B2017/32113
摘要： A vascular catheter includes a blade tip at its distal end. In the specific embodiments, a blade is mounted within the blade tip and a mechanism provided for extending the blade transversely when the blade tip is located within a region of stenosis. By extending the blade and axially translating the catheter so that the blade forms an incision within the region of stenosis, improved angioplastic treatment can be achieved.
摘要翻译： 血管导管在其远端包括叶片尖端。 在具体实施例中，叶片安装在叶片尖端内，并且设置用于当叶片尖端位于狭窄区域内时横向延伸叶片的机构。 通过延伸叶片并轴向平移导管，使得叶片在狭窄区域内形成切口，可以实现改进的血管生成处理。
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公开(公告)号：US5092873A
公开(公告)日：1992-03-03
申请号：US486675
申请日：1990-02-28
CPC分类号： A61B17/320783 , B29C65/18 , B29C65/305 , B29C65/48 , B29C66/532 , B29C66/61 , B29C66/81455 , A61B2017/22052 , A61B2017/22054 , A61B2017/22075 , A61M25/1002 , A61M25/1011 , B29L2031/7542
摘要： A vascular catheter includes a flexible catheter body having proximal and distal ends and an elongate housing secured to the distal end of the catheter body. An interactional device is disposed on one side of the housing, and at least two spaced-apart inflatable chambers are located on the other side of the housing generally at its proximal and distal ends, respectively. The inflatable chambers may be expanded simutaneously or separately, and the spaced-apart positioning of the chambers provides for stable positioning of the housing during atherectomy procedures imaging procedures, and the like.
摘要翻译： 血管导管包括具有近端和远端的柔性导管主体和固定到导管主体的远端的细长外壳。 交互装置设置在壳体的一侧上，并且至少两个间隔开的可充气腔室分别位于壳体的另一侧，大致在其近端和远端。 可膨胀的腔室可以同时或分开地扩张，腔室的间隔开的定位在动脉粥样硬化切除术过程成像过程等期间提供壳体的稳定定位。
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公开(公告)号：US5441510A
公开(公告)日：1995-08-15
申请号：US250319
申请日：1994-05-27
申请人： John B. Simpson , Scott C. Anderson , John J. Frantzen , Peter S. Brown , James M. Cannon, Jr. , Geoffrey A. Orth
发明人： John B. Simpson , Scott C. Anderson , John J. Frantzen , Peter S. Brown , James M. Cannon, Jr. , Geoffrey A. Orth
CPC分类号： A61B17/320783
摘要： An cutter apparatus for removing obstructive tissue has a distal housing having a window for invaginating tissue. An axially reciprocating and rotating cutting blade makes successive longitudinal cuts while slowly rotating across the open window. An axial guide assembly holds the cutting edge of the blade in a cutting path immediately adjacent to the inner surface of the housing. The shape and motion of the cutting blade pares off a generally uniformly thick slice of tissue from the stenosis and directs it toward the interior of the housing. A spiral parting edge opposed to the rotating cutting edge provides clean separation of the tissue slice from the stenosis. The tissue slice is received in a chamber internal to the housing and is retained by the blade and guide assembly for later removal from the patient.
摘要翻译： 用于去除阻塞性组织的切割装置具有远端壳体，该远侧壳体具有用于使组织入口的窗口。 轴向往复和旋转的切割刀片在连续纵向切割的同时缓慢地旋转穿过打开的窗口。 轴向引导组件将刀片的切割刃保持在紧邻壳体内表面的切割路径中。 切割刀片的形状和运动从狭窄中分离出大致均匀厚度的组织片，并将其引导到壳体的内部。 与旋转的切割刃相对的螺旋分割边缘提供组织切片与狭窄的清楚分离。 组织切片被容纳在壳体内部的腔室中，并被刀片和引导组件保持，以便以后从患者移除。
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公开(公告)号：US4926858A
公开(公告)日：1990-05-22
申请号：US391636
申请日：1989-08-07
IPC分类号： A61B10/00 , A61B10/02 , A61B10/04 , A61B17/00 , A61B17/22 , A61B17/32 , A61B19/00 , A61F2/01 , A61F2/958 , A61M29/02
CPC分类号： A61B17/32075 , A61B17/22031 , A61B17/320016 , A61B17/320783 , A61M25/1018 , A61M29/02 , A61B10/0275 , A61B10/04 , A61B2017/00845 , A61B2017/00853 , A61B2017/22038 , A61B2017/22052 , A61B2017/22074 , A61B2017/22075 , A61B2090/064 , A61B2090/3933 , A61B90/06 , A61F2/01 , A61M2025/1093
摘要： An atherectomy catheter for removal of plaque buildup from the walls of a blood vessel. The atherectomy catheter includes a cutter assembly disposed at the distal end of a flexible guide tube that may be inserted into a vessel and directed to the occlusion. A proximal actuator assembly is adapted to impart both rotary and axial movement to the cutter. The cutter assembly includes a cutter having a forwardly extending annular cutting surface. A guide wire with a flexible spring tip extends forward of the cutter for guiding the cutter as it travels axially through the artery. All of the removed atheroma materials are collected within the device and a retention member carried by the guide wire and positioned in front of the cutter forms a cap to retain the collected atheroma materials. In a disclosed embodiment, the retention member is expandable, and in one of the preferred embodiments, the retention member may be expanded to engage the vessel walls to anchor the device during the cutting stroke.
摘要翻译： 用于从血管壁去除斑块积聚的粥样斑块切除术导管。 粥样斑块切除术导管包括设置在柔性引导管的远端处的切割器组件，其可以插入容器并被引导到闭塞。 近端致动器组件适于将旋转和轴向运动赋予刀具。 切割器组件包括具有向前延伸的环形切割表面的切割器。 具有柔性弹簧尖端的引导线在切割器的前方延伸，用于当切割器轴向地穿过动脉时引导切割器。 所有去除的动脉粥样硬化材料被收集在装置内，并且由导丝承载并定位在切割器前面的保持构件形成盖以保持收集的动脉粥样化材料。 在公开的实施例中，保持构件是可膨胀的，并且在优选实施例之一中，保持构件可以被膨胀以接合容器壁，以在切割行程期间锚固该装置。
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公开(公告)号：US09498600B2
公开(公告)日：2016-11-22
申请号：US12829277
申请日：2010-07-01
申请人： Michael H. Rosenthal , Michael Zung , Nicholas J. Spinelli , Charles W. McNall , John B. Simpson , John F. Black
发明人： Michael H. Rosenthal , Michael Zung , Nicholas J. Spinelli , Charles W. McNall , John B. Simpson , John F. Black
IPC分类号： A61M25/01 , A61M25/00 , A61B17/3207 , A61B17/29
CPC分类号： A61B17/320758 , A61B17/32075 , A61B90/361 , A61B2017/2927 , A61B2017/320064 , A61B2017/320766 , A61B2017/320791 , A61B2090/3614 , A61M25/0074 , A61M25/0133
摘要： Described herein are atherectomy catheters, systems and methods that include a distal tip region that may be moved laterally so that its long axis is parallel with the long axis of the main catheter body axis. Displacing the distal tip region laterally out of the main catheter body axis exposes an annular blade and opens a passageway for cut tissue to enter a storage region within the catheter. The annular blade may be internally coupled to a drive shaft that rotates the blade, and thus the exposed blade edge may have the same crossing profile (OD) as the rest of the distal end region of the catheter. Also described herein are gear-driven atherectomy devices that may use a cable drive shaft to actuate the annular blade. Both push-to-cut and pull-to-cut variations are described, as are methods for cutting tissue and systems including these atherectomy catheters.
摘要翻译： 这里描述了动脉粥样硬化切除术导管，系统和方法，其包括可以横向移动的远侧末端区域，使得其长轴线与主导管主体轴线的长轴平行。 将远端尖端区域横向偏离主导管主体轴线暴露环形刀片并打开用于切割组织的通道进入导管内的存储区域。 环形叶片可以内部联接到旋转叶片的驱动轴，因此暴露的叶片边缘可以具有与导管的远端区域的其余部分相同的交叉轮廓（OD）。 这里还描述了可以使用电缆驱动轴致动环形刀片的齿轮驱动的粥样斑块切除装置。 描述了切割和切割的变化，以及用于切割包括这些粥样斑块切除术导管的组织和系统的方法。
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公开(公告)号：US20120330336A1
公开(公告)日：2012-12-27
申请号：US13536497
申请日：2012-06-28
申请人： John B. Simpson , Himanshu Patel , Greg Stine , Brett Follmer , Michael H. Rosenthal , Mehrdad Farhangnia
发明人： John B. Simpson , Himanshu Patel , Greg Stine , Brett Follmer , Michael H. Rosenthal , Mehrdad Farhangnia
IPC分类号： A61B17/22
CPC分类号： A61B17/320758 , A61B10/04 , A61B17/32075 , A61B17/320783 , A61B2010/0225 , A61B2017/00685 , A61B2017/320032 , A61B2017/320791
摘要： A method of removing material from a blood flow lumen includes providing a device having a cutting element and an opening, the cutting element being movable relative to the opening. The method then includes advancing the device through a patient's vascular system to the blood flow lumen. Finally, the method involves moving the cutting element and the opening relative to the blood flow lumen so that a continuous piece of material is severed by the cutting element and directed into the opening as the cutting element and opening move through the blood flow lumen, the continuous piece of severed material being directed into the device for removal from the patient. The method may include providing a device having a rotatable cutter that, in some embodiments, is not parallel to the longitudinal axis of the device, is movable, has retracted and deployed positions, or any combination thereof.
摘要翻译： 从血流腔去除材料的方法包括提供具有切割元件和开口的装置，所述切割元件可相对于所述开口移动。 该方法然后包括将装置通过患者的血管系统推进到血流腔。 最后，该方法包括相对于血液流动腔移动切割元件和开口，使得当切割元件和开口移动通过血流腔时，连续片材被切割元件切断并引导到开口中， 连续切断的材料被引导到装置中以从患者身上取出。 该方法可以包括提供具有可旋转切割器的装置，其在一些实施例中不平行于装置的纵向轴线，是可移动的，具有缩回和展开位置或其任何组合。
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公开(公告)号：US20120322688A1
公开(公告)日：2012-12-20
申请号：US13598154
申请日：2012-08-29
申请人： Angela Soito , John B. Simpson
发明人： Angela Soito , John B. Simpson
CPC分类号： G01N33/68 , A61B10/0233 , A61B17/22 , Y10T436/25
摘要： Lumenectomy material is tested to determine the presence or likelihood of a condition of a patient. The lumenectomy material is in the form of at least one continuous tissue strand collected in vivo from an inner surface of a body lumen of the patient. The presence of at least one marker of a disease is determined. The disease may be hypertension, hyperlipidemia, depression, obesity, metabolic syndrome, insulin resistance, kidney damage, or diabetes. The patient is identified as having or as likely to develop the disease if a marker of the disease is identified in the lumenectomy material of the patient.
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公开(公告)号：US20120129163A1
公开(公告)日：2012-05-24
申请号：US13362249
申请日：2012-01-31
申请人： Angela Soito , John B. Simpson
发明人： Angela Soito , John B. Simpson
CPC分类号： G01N33/68 , A61B10/0233 , A61B17/22 , Y10T436/25
摘要： Lumenectomy material is tested to determine the presence or likelihood of a condition of a patient. The lumenectomy material is in the form of at least one continuous tissue strand collected in vivo from an inner surface of a body lumen of the patient. The presence of at least one marker of a disease is determined. The disease may be hypertension, hyperlipidemia, depression, obesity, metabolic syndrome, insulin resistance, kidney damage, or diabetes. The patient is identified as having or as likely to develop the disease if a marker of the disease is identified in the lumenectomy material of the patient.
摘要翻译： 测量肿瘤切除术材料以确定患者状况的存在或可能性。 所述内腔切除术材料是从患者体腔的内表面在体内收集的至少一个连续组织线的形式。 确定存在至少一种疾病的标志物。 该疾病可以是高血压，高脂血症，抑郁症，肥胖，代谢综合征，胰岛素抵抗，肾损伤或糖尿病。 如果在患者的内腔切除术材料中鉴定出疾病的标志物，则该患者被鉴定为具有或可能发展该疾病。
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公开(公告)号：US20100198240A1
公开(公告)日：2010-08-05
申请号：US12757291
申请日：2010-04-09
申请人： John B. Simpson , Himanshu Patel , Greg Stine , Brett Follmer , Michael H. Rosenthal , Mehrdad Farhangnia
发明人： John B. Simpson , Himanshu Patel , Greg Stine , Brett Follmer , Michael H. Rosenthal , Mehrdad Farhangnia
CPC分类号： A61B17/320758 , A61B10/04 , A61B17/32075 , A61B17/320783 , A61B2010/0225 , A61B2017/00685 , A61B2017/320032 , A61B2017/320791
摘要： A method of removing material from a blood flow lumen includes providing a device having a cutting element and an opening, the cutting element being movable relative to the opening. The method then includes advancing the device through a patient's vascular system to the blood flow lumen. Finally, the method involves moving the cutting element and the opening relative to the blood flow lumen so that a continuous piece of material is severed by the cutting element and directed into the opening as the cutting element and opening move through the blood flow lumen, the continuous piece of severed material being directed into the device for removal from the patient. The method may include providing a device having a rotatable cutter that, in some embodiments, is not parallel to the longitudinal axis of the device, is movable, has retracted and deployed positions, or any combination thereof. The method may further include forcing the opening toward the wall of the vascular site after the advancing step and before the moving step.
摘要翻译： 从血流腔去除材料的方法包括提供具有切割元件和开口的装置，所述切割元件可相对于所述开口移动。 该方法然后包括将装置通过患者的血管系统推进到血流腔。 最后，该方法包括相对于血液流动腔移动切割元件和开口，使得当切割元件和开口移动通过血流腔时，连续片材被切割元件切断并引导到开口中， 连续切断的材料被引导到装置中以从患者身上取出。 该方法可以包括提供具有可旋转切割器的装置，其在一些实施例中不平行于装置的纵向轴线，是可移动的，具有缩回和展开位置或其任何组合。 该方法还可以包括在推进步骤之后和移动步骤之前迫使开口朝向血管部位的壁。
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