公开(公告)号：US07811610B2

公开(公告)日：2010-10-12

申请号：US10557293

申请日：2004-05-21

申请人： John Babish ,  Matthew Tripp ,  Terrence Howell ,  Jeffrey S. Bland ,  Gary Darland ,  Robert Lerman ,  Daniel O. Lukaczer

发明人： John Babish ,  Matthew Tripp ,  Terrence Howell ,  Jeffrey S. Bland ,  Gary Darland ,  Robert Lerman ,  Daniel O. Lukaczer

IPC分类号： A01N65/00

CPC分类号： A61K31/00 ,  A61K31/192 ,  A61K31/365 ,  A61K31/405 ,  A61K31/415 ,  A61K36/185 ,  A61K45/06 ,  A61K2300/00

摘要： The invention provides hops (Humulus lupulus) extracts or derivatives thereof for use in treating a patient prophylactically and/or therapeutically for ulcerogenic-type disorders of the stomach and/or intestines. The ulcerogenic disorders can be of the type chemically induced, environmentally-induced, infection-induced, and/or stress-induced. The invention also provides a pharmaceutical composition comprising an active amount of hops extracts or derivatives thereof, in combination with an analgesic compound and/or an anti-inflammatory compound. The invention further provides for use of hops extracts or derivatives thereof, significantly reducing and/or therapeutically treating ulcerogenic-type disorders of the stomach and/or intestines.

公开(公告)号：US08486457B2

公开(公告)日：2013-07-16

申请号：US10532388

申请日：2003-10-20

申请人： Matthew L. Tripp ,  John G. Babish ,  Jeffrey S. Bland ,  Gary Darland ,  Robert Lerman ,  Daniel O. Lukaczer ,  DeAnn J. Liska ,  Terrence Howell

发明人： Matthew L. Tripp ,  John G. Babish ,  Jeffrey S. Bland ,  Gary Darland ,  Robert Lerman ,  Daniel O. Lukaczer ,  DeAnn J. Liska ,  Terrence Howell

IPC分类号： A01N65/00

CPC分类号： A61K36/185 ,  A61K31/122 ,  A61K36/53 ,  A61K2300/00

摘要： A natural formulation of compounds that would to modulate inflammation is disclosed. The formulation would also inhibit expression of COX-2, inhibit synthesis of prostaglandins selectively in target cells, and inhibit inflammatory response selectively in target cells. The compositions containing at least one fraction isolated or derived from hops. Other embodiments relate to combinations of components, including at least one fraction isolated or derived from hops, tryptanthrin and conjugates thereof, rosemary, an extract or compound derived from rosemary, a triterpene species, or a diterpene lactone or derivatives or conjugates thereof.

摘要翻译： 公开了将调节炎症的化合物的天然制剂。 该制剂还可抑制COX-2的表达，在靶细胞中选择性抑制前列腺素的合成，并在靶细胞中选择性抑制炎症反应。 所述组合物含有至少一个分离或衍生自啤酒花的级分。 其它实施方案涉及组分的组合，包括至少一种分离或衍生自啤酒花的蛋白质，色胺及其缀合物，迷迭香，源自迷迭香的提取物或化合物，三萜类物质或二萜内酯或其衍生物或缀合物。

公开(公告)号：US20060127514A1

公开(公告)日：2006-06-15

申请号：US11344556

申请日：2006-01-30

申请人： Matthew Tripp ,  John Babish ,  Jeffrey Bland ,  Gary Darland ,  Robert Lerman ,  Daniel Lukaczer ,  DeAnn Liska ,  Terrence Howell

发明人： Matthew Tripp ,  John Babish ,  Jeffrey Bland ,  Gary Darland ,  Robert Lerman ,  Daniel Lukaczer ,  DeAnn Liska ,  Terrence Howell

IPC分类号： A61K36/185 ,  A61K31/12

CPC分类号： A61K31/122 ,  A61K31/12 ,  A61K36/185 ,  A61K36/53 ,  A61K2300/00

摘要： A natural formulation of compounds that would to modulate inflammation is disclosed. The formulation would also inhibit expression of COX-2, inhibit synthesis of prostaglandins selectively in target cells, and inhibit inflammatory response selectively in target cells. The compositions containing at least one fraction isolated or derived from hops. Other embodiments relate to combinations of components, including at least one fraction isolated or derived from hops, tryptanthrin and conjugates thereof, rosemary, an extract or compound derived from rosemary, a triterpene species, or a diterpene lactone or derivatives or conjugates thereof.

公开(公告)号：US20070160692A1

公开(公告)日：2007-07-12

申请号：US10532388

申请日：2003-10-20

申请人： Matthew Tripp ,  John Babish ,  Jeffrey Bland ,  Gary Darland ,  Robert Lerman ,  Daniel Lukaczer ,  DeAnn Liska ,  Terrence Howell

发明人： Matthew Tripp ,  John Babish ,  Jeffrey Bland ,  Gary Darland ,  Robert Lerman ,  Daniel Lukaczer ,  DeAnn Liska ,  Terrence Howell

IPC分类号： A61K36/53 ,  A61K31/22 ,  A61K36/185

CPC分类号： A61K36/185 ,  A61K31/122 ,  A61K36/53 ,  A61K2300/00

摘要： A natural formulation of compounds that would to modulate inflammation is disclosed. The formulation would also inhibit expression of COX-2, inhibit synthesis of prostaglandins selectively in target cells, and inhibit inflammatory response selectively in target cells. The compositions containing at least one fraction isolated or derived from hops. Other embodiments relate to combinations of components, including at least one fraction isolated or derived from hops, tryptanthrin and conjugates thereof, rosemary, an extract or compound derived from rosemary, a triterpene species, or a diterpene lactone or derivatives or conjugates thereof.

摘要翻译： 公开了将调节炎症的化合物的天然制剂。 该制剂还可抑制COX-2的表达，在靶细胞中选择性抑制前列腺素的合成，并在靶细胞中选择性抑制炎症反应。 所述组合物含有至少一个分离或衍生自啤酒花的级分。 其它实施方案涉及组分的组合，包括至少一种分离或衍生自啤酒花的蛋白质，色胺及其缀合物，迷迭香，源自迷迭香的提取物或化合物，三萜类物质或二萜内酯或其衍生物或缀合物。

公开(公告)号：US20060127516A1

公开(公告)日：2006-06-15

申请号：US11344559

申请日：2006-01-30

申请人： Matthew Tripp ,  John Babish ,  Jeffrey Bland ,  Gary Darland ,  Robert Lerman ,  Daniel Lukaczer ,  DeAnn Liska ,  Terrence Howell

发明人： Matthew Tripp ,  John Babish ,  Jeffrey Bland ,  Gary Darland ,  Robert Lerman ,  Daniel Lukaczer ,  DeAnn Liska ,  Terrence Howell

IPC分类号： A61K36/185 ,  A61K31/12

CPC分类号： A61K36/185 ,  A61K31/12

摘要： A natural formulation of compounds that would to modulate inflammation is disclosed. The formulation would also inhibit expression of COX-2, inhibit synthesis of prostaglandins selectively in target cells, and inhibit inflammatory response selectively in target cells. The compositions containing at least one fraction isolated or derived from hops.

摘要翻译： 公开了将调节炎症的化合物的天然制剂。 该制剂还可抑制COX-2的表达，在靶细胞中选择性抑制前列腺素的合成，并在靶细胞中选择性抑制炎症反应。 所述组合物含有至少一个分离或衍生自啤酒花的级分。

公开(公告)号：US20060127513A1

公开(公告)日：2006-06-15

申请号：US11344555

申请日：2006-01-30

申请人： Matthew Tripp ,  John Babish ,  Jeffrey Bland ,  Gary Darland ,  Robert Lerman ,  Daniel Lukaczer ,  DeAnn Liska ,  Terrence Howell

发明人： Matthew Tripp ,  John Babish ,  Jeffrey Bland ,  Gary Darland ,  Robert Lerman ,  Daniel Lukaczer ,  DeAnn Liska ,  Terrence Howell

IPC分类号： A61K36/185 ,  A61K31/12

CPC分类号： A61K31/122 ,  A61K31/12 ,  A61K36/185 ,  A61K36/53 ,  A61K2300/00

摘要： A natural formulation of compounds that would to modulate inflammation is disclosed. The formulation would also inhibit expression of COX-2, inhibit synthesis of prostaglandins selectively in target cells, and inhibit inflammatory response selectively in target cells. The compositions containing at least one fraction isolated or derived from hops. Other embodiments relate to combinations of components, including at least one fraction isolated or derived from hops, tryptanthrin and conjugates thereof, rosemary, an extract or compound derived from rosemary, a triterpene species, or a diterpene lactone or derivatives or conjugates thereof.

摘要翻译： 公开了将调节炎症的化合物的天然制剂。 该制剂还可抑制COX-2的表达，在靶细胞中选择性抑制前列腺素的合成，并在靶细胞中选择性抑制炎症反应。 所述组合物含有至少一个分离或衍生自啤酒花的级分。 其它实施方案涉及组分的组合，包括至少一种分离或衍生自啤酒花的蛋白质，色胺及其缀合物，迷迭香，源自迷迭香的提取物或化合物，三萜类物质或二萜内酯或其衍生物或缀合物。

公开(公告)号：US20060177531A1

公开(公告)日：2006-08-10

申请号：US11403016

申请日：2006-04-12

申请人： Matthew Tripp ,  John Babish ,  Jeffrey Bland ,  Gary Darland ,  Robert Lerman ,  Daniel Lukaczer ,  DeAnn Liska ,  Terrence Howell

发明人： Matthew Tripp ,  John Babish ,  Jeffrey Bland ,  Gary Darland ,  Robert Lerman ,  Daniel Lukaczer ,  DeAnn Liska ,  Terrence Howell

IPC分类号： A61K36/185 ,  A61K31/12

CPC分类号： A61K31/12 ,  A61K36/185 ,  A61K36/53 ,  A61K45/06 ,  A61K2300/00

摘要： A natural formulation of compounds that would to modulate inflammation is disclosed. The formulation would also inhibit expression of COX-2, inhibit synthesis of prostaglandins selectively in target cells, and inhibit inflammatory response selectively in target cells. The compositions containing at least one fraction isolated or derived from hops. Other embodiments relate to combinations of components, including at least one fraction isolated or derived from hops, tryptanthrin and conjugates thereof, rosemary, an extract or compound derived from rosemary, a triterpene species, or a diterpene lactone or derivatives or conjugates thereof.

公开(公告)号：US20060141082A1

公开(公告)日：2006-06-29

申请号：US11355306

申请日：2006-02-15

申请人： John Babish ,  Matthew Tripp ,  Jeffrey Bland ,  Terrence Howell ,  Gary Darland ,  Robert Lerman ,  Daniel Lukaczer

发明人： John Babish ,  Matthew Tripp ,  Jeffrey Bland ,  Terrence Howell ,  Gary Darland ,  Robert Lerman ,  Daniel Lukaczer

IPC分类号： A61K36/185 ,  A61K31/12 ,  A61K31/192

CPC分类号： A61K31/12 ,  A61K31/192 ,  A61K36/185 ,  A61K2300/00

摘要： The invention provides hops (Humulis lupulus) extracts or derivatives thereof for use in treating a patient prophylactically and/or therapeutically for ulcerogenic-type disorders of the stomach and/or intestines. The ulcerogenic disorders can be of the type chemically induced, environmentally-induced, infection-induced, and/or stress-induced. The invention also provides a pharmaceutical composition comprising an active amount of hops extracts or derivatives thereof, in combination with an analgesic compound and/or an anti-inflammatory compound. The invention further provides for use of hops extracts or derivatives thereof, significantly reducing and/or therapeutically treating ulcerogenic-type disorders of the stomach and/or intestines.

摘要翻译： 本发明提供啤酒花（Humulis lupulus）提取物或其衍生物，其用于预防性和/或治疗性地对胃和/或肠的溃疡型障碍进行治疗。 溃疡性疾病可以是化学诱导型，环境诱导型，感染诱导型和/或应激诱导型。 本发明还提供了包含活力量的啤酒花提取物或其衍生物与止痛化合物和/或抗炎化合物组合的药物组合物。 本发明进一步提供啤酒花提取物或其衍生物的使用，显着减少和/或治疗性地治疗胃和/或肠的溃疡形成型疾病。

公开(公告)号：US20060127517A1

公开(公告)日：2006-06-15

申请号：US11344561

申请日：2006-01-30

申请人： Matthew Tripp ,  John Babish ,  Jeffrey Bland ,  Gary Darland ,  Robert Lerman ,  Daniel Lukaczer ,  DeAnn Liska ,  Terrence Howell

发明人： Matthew Tripp ,  John Babish ,  Jeffrey Bland ,  Gary Darland ,  Robert Lerman ,  Daniel Lukaczer ,  DeAnn Liska ,  Terrence Howell

IPC分类号： A61K36/185 ,  A61K31/12

CPC分类号： A61K31/122 ,  A61K31/12 ,  A61K36/185 ,  A61K36/53 ,  A61K2300/00

摘要： A natural formulation of compounds that would to modulate inflammation is disclosed. The formulation would also inhibit expression of COX-2, inhibit synthesis of prostaglandins selectively in target cells, and inhibit inflammatory response selectively in target cells. The compositions containing at least one fraction isolated or derived from hops. Other embodiments relate to combinations of components, including at least one fraction isolated or derived from hops, tryptanthrin and conjugates thereof, rosemary, an extract or compound derived from rosemary, a triterpene species, or a diterpene lactone or derivatives or conjugates thereof.

公开(公告)号：US20060127515A1

公开(公告)日：2006-06-15

申请号：US11344557

申请日：2006-01-30

申请人： Matthew Tripp ,  John Babish ,  Jeffrey Bland ,  Gary Darland ,  Robert Lerman ,  Daniel Lukaczer ,  DeAnn Liska ,  Terrence Howell

发明人： Matthew Tripp ,  John Babish ,  Jeffrey Bland ,  Gary Darland ,  Robert Lerman ,  Daniel Lukaczer ,  DeAnn Liska ,  Terrence Howell

IPC分类号： A61K36/185 ,  A61K31/12

CPC分类号： A61K31/122 ,  A61K31/12 ,  A61K36/185 ,  A61K36/53 ,  A61K2300/00

摘要： A natural formulation of compounds that would to modulate inflammation is disclosed. The formulation would also inhibit expression of COX-2, inhibit synthesis of prostaglandins selectively in target cells, and inhibit inflammatory response selectively in target cells. The compositions containing at least one fraction isolated or derived from hops. Other embodiments relate to combinations of components, including at least one fraction isolated or derived from hops, tryptanthrin and conjugates thereof, rosemary, an extract or compound derived from rosemary, a triterpene species, or a diterpene lactone or derivatives or conjugates thereof.