公开(公告)号：US20060048780A1

公开(公告)日：2006-03-09

申请号：US11076418

申请日：2005-03-09

申请人： John Burr ,  Adrian Smith ,  Randy Hall ,  Herm Snyder ,  Carlos Schuler ,  George Axford ,  Charles Ray

发明人： John Burr ,  Adrian Smith ,  Randy Hall ,  Herm Snyder ,  Carlos Schuler ,  George Axford ,  Charles Ray

IPC分类号： A61M15/00 ,  B65D83/06

CPC分类号： A61M15/0028 ,  A61M15/0036 ,  A61M15/0086 ,  A61M2202/064 ,  A61M2205/07 ,  A61M2205/073 ,  B05B11/062

摘要： The invention provides various apparatus and methods for aerosolizing a powdered medicament. In one exemplary embodiment, an apparatus includes a pressurization cylinder, and a piston which is slidable within the cylinder to pressurize a gas. A handle is coupled to the piston and is movable between an extended position and a home position to pressurize the gas. An aerosolizing mechanism is included and is configured to aerosolize a powdered medicament that is held within a receptacle with pressurized gas from the cylinder. A carriage assembly is included to receive the receptacle and to couple the receptacle to the aerosolizing mechanism. A first and a second interlock are operably engageable with the carriage assembly to prevent coupling of the receptacle with the aerosolization mechanism. The first interlock is released to allow movement of the carriage upon movement of the handle to the extended position. The second interlock remains engaged if the receptacle is only partially inserted into the carriage assembly.

公开(公告)号：US08161969B2

公开(公告)日：2012-04-24

申请号：US12077877

申请日：2008-03-21

申请人： John D. Burr ,  Adrian E. Smith ,  Randy K. Hall ,  Herm Snyder ,  Carlos A. Schuler ,  George S. Axford ,  Charles Ray

发明人： John D. Burr ,  Adrian E. Smith ,  Randy K. Hall ,  Herm Snyder ,  Carlos A. Schuler ,  George S. Axford ,  Charles Ray

IPC分类号： A61M15/00 ,  A61M16/00

CPC分类号： A61M15/0028 ,  A61M15/0036 ,  A61M15/0086 ,  A61M2202/064 ,  A61M2205/07 ,  A61M2205/073 ,  B05B11/062

摘要： The invention provides various apparatus and methods for aerosolizing a powdered medicament. In one exemplary embodiment, an apparatus includes a pressurization cylinder, and a piston which is slidable within the cylinder to pressurize a gas. A handle is coupled to the piston and is movable between an extended position and a home position to pressurize the gas. An aerosolizing mechanism is included and is configured to aerosolize a powdered medicament that is held within a receptacle with pressurized gas from the cylinder. A carriage assembly is included to receive the receptacle and to couple the receptacle to the aerosolizing mechanism. A first and a second interlock are operably engageable with the carriage assembly to prevent coupling of the receptacle with the aerosolization mechanism. The first interlock is released to allow movement of the carriage upon movement of the handle to the extended position. The second interlock remains engaged if the receptacle is only partially inserted into the carriage assembly.

摘要翻译： 本发明提供了用于使粉末状药物雾化的各种装置和方法。 在一个示例性实施例中，一种装置包括加压缸和可在气缸内滑动以对气体加压的活塞。 手柄联接到活塞并且可以在延伸位置和原始位置之间移动以对气体加压。 包括雾化机构，并且被配置为使来自气缸的加压气体保持在容器内的粉末状药物雾化。 包括支架组件以接收容器并将容器连接到雾化机构。 第一和第二互锁可操作地与托架组件接合以防止容器与雾化机构的联接。 第一互锁被释放以允许滑架在手柄移动到延伸位置时移动。 如果容器仅部分地插入到滑架组件中，则第二互锁保持接合。

公开(公告)号：US20080230058A1

公开(公告)日：2008-09-25

申请号：US12077877

申请日：2008-03-21

申请人： John D. Burr ,  Adrian E. Smith ,  Randy K. Hall ,  Herm Snyder ,  Carlos A. Schuler ,  George S. Axford ,  Charles Ray

发明人： John D. Burr ,  Adrian E. Smith ,  Randy K. Hall ,  Herm Snyder ,  Carlos A. Schuler ,  George S. Axford ,  Charles Ray

IPC分类号： A61M15/00

CPC分类号： A61M15/0028 ,  A61M15/0036 ,  A61M15/0086 ,  A61M2202/064 ,  A61M2205/07 ,  A61M2205/073 ,  B05B11/062

摘要： The invention provides various apparatus and methods for aerosolizing a powdered medicament. In one exemplary embodiment, an apparatus includes a pressurization cylinder, and a piston which is slidable within the cylinder to pressurize a gas. A handle is coupled to the piston and is movable between an extended position and a home position to pressurize the gas. An aerosolizing mechanism is included and is configured to aerosolize a powdered medicament that is held within a receptacle with pressurized gas from the cylinder. A carriage assembly is included to receive the receptacle and to couple the receptacle to the aerosolizing mechanism. A first and a second interlock are operably engageable with the carriage assembly to prevent coupling of the receptacle with the aerosolization mechanism. The first interlock is released to allow movement of the carriage upon movement of the handle to the extended position. The second interlock remains engaged if the receptacle is only partially inserted into the carriage assembly.

公开(公告)号：US20060160871A1

公开(公告)日：2006-07-20

申请号：US11296108

申请日：2005-12-06

申请人： Srinivas Palakodaty ,  Jiang Zhang ,  Andreas Kordikowski ,  Linda Daintree ,  Sarma Duddu ,  Alan Kugler ,  Herm Snyder ,  David Lechuga-Ballesteros ,  Nagesh Palepu ,  Michael Eldon

发明人： Srinivas Palakodaty ,  Jiang Zhang ,  Andreas Kordikowski ,  Linda Daintree ,  Sarma Duddu ,  Alan Kugler ,  Herm Snyder ,  David Lechuga-Ballesteros ,  Nagesh Palepu ,  Michael Eldon

IPC分类号： A61K31/4184

CPC分类号： A61K9/1635 ,  A61K9/146 ,  A61K9/1652 ,  A61K9/2077 ,  A61K31/4174 ,  A61K31/4178 ,  A61K31/4184 ,  A61K47/6951 ,  B82Y5/00

摘要： One or more embodiments of the invention provide various novel formulations, and tablet dosage forms, comprising losartan that are non-crystalline, stable, and/or otherwise improvements over known losartan formulations. One or more embodiments of the invention further provide methods for preparing the formulation, methods for preparing the tablet dosage form, and to methods of administering the tablet dosage and/or formulation comprising losartan. The losartan-containing formulations may be administered to a user to treat hypertension, and related conditions.

摘要翻译： 本发明的一个或多个实施方案提供各种新型制剂和片剂剂型，其包含与已知氯沙坦制剂相比非结晶，稳定和/或以其它方式改善的氯沙坦。 本发明的一个或多个实施方案还提供了制备制剂的方法，制备片剂剂型的方法，以及施用包含氯沙坦的片剂剂量和/或制剂的方法。 含氯沙坦的制剂可以施用于使用者来治疗高血压和相关的病症。