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公开(公告)号：US20080230058A1
公开(公告)日：2008-09-25
申请号：US12077877
申请日：2008-03-21
申请人： John D. Burr , Adrian E. Smith , Randy K. Hall , Herm Snyder , Carlos A. Schuler , George S. Axford , Charles Ray
发明人： John D. Burr , Adrian E. Smith , Randy K. Hall , Herm Snyder , Carlos A. Schuler , George S. Axford , Charles Ray
IPC分类号： A61M15/00
CPC分类号： A61M15/0028 , A61M15/0036 , A61M15/0086 , A61M2202/064 , A61M2205/07 , A61M2205/073 , B05B11/062
摘要： The invention provides various apparatus and methods for aerosolizing a powdered medicament. In one exemplary embodiment, an apparatus includes a pressurization cylinder, and a piston which is slidable within the cylinder to pressurize a gas. A handle is coupled to the piston and is movable between an extended position and a home position to pressurize the gas. An aerosolizing mechanism is included and is configured to aerosolize a powdered medicament that is held within a receptacle with pressurized gas from the cylinder. A carriage assembly is included to receive the receptacle and to couple the receptacle to the aerosolizing mechanism. A first and a second interlock are operably engageable with the carriage assembly to prevent coupling of the receptacle with the aerosolization mechanism. The first interlock is released to allow movement of the carriage upon movement of the handle to the extended position. The second interlock remains engaged if the receptacle is only partially inserted into the carriage assembly.
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公开(公告)号：US08161969B2
公开(公告)日：2012-04-24
申请号：US12077877
申请日：2008-03-21
申请人： John D. Burr , Adrian E. Smith , Randy K. Hall , Herm Snyder , Carlos A. Schuler , George S. Axford , Charles Ray
发明人： John D. Burr , Adrian E. Smith , Randy K. Hall , Herm Snyder , Carlos A. Schuler , George S. Axford , Charles Ray
CPC分类号： A61M15/0028 , A61M15/0036 , A61M15/0086 , A61M2202/064 , A61M2205/07 , A61M2205/073 , B05B11/062
摘要： The invention provides various apparatus and methods for aerosolizing a powdered medicament. In one exemplary embodiment, an apparatus includes a pressurization cylinder, and a piston which is slidable within the cylinder to pressurize a gas. A handle is coupled to the piston and is movable between an extended position and a home position to pressurize the gas. An aerosolizing mechanism is included and is configured to aerosolize a powdered medicament that is held within a receptacle with pressurized gas from the cylinder. A carriage assembly is included to receive the receptacle and to couple the receptacle to the aerosolizing mechanism. A first and a second interlock are operably engageable with the carriage assembly to prevent coupling of the receptacle with the aerosolization mechanism. The first interlock is released to allow movement of the carriage upon movement of the handle to the extended position. The second interlock remains engaged if the receptacle is only partially inserted into the carriage assembly.
摘要翻译： 本发明提供了用于使粉末状药物雾化的各种装置和方法。 在一个示例性实施例中，一种装置包括加压缸和可在气缸内滑动以对气体加压的活塞。 手柄联接到活塞并且可以在延伸位置和原始位置之间移动以对气体加压。 包括雾化机构，并且被配置为使来自气缸的加压气体保持在容器内的粉末状药物雾化。 包括支架组件以接收容器并将容器连接到雾化机构。 第一和第二互锁可操作地与托架组件接合以防止容器与雾化机构的联接。 第一互锁被释放以允许滑架在手柄移动到延伸位置时移动。 如果容器仅部分地插入到滑架组件中，则第二互锁保持接合。
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公开(公告)号：US07905230B2
公开(公告)日：2011-03-15
申请号：US10734076
申请日：2003-12-10
申请人： Carlos A. Schuler , William Alston
发明人： Carlos A. Schuler , William Alston
CPC分类号： A61M15/00 , A61M15/0096 , A61M2205/3306
摘要： An aerosolization device comprises a housing, a container comprising a reservoir storing a pharmaceutical formulation which comprises a propellant, and a metering valve. The metering valve is in communication with the reservoir and is moveable into the container to an actuated position where a predetermined amount of the pharmaceutical formulation is released. A contact member is provided in the housing. In one version, the contact member is moveable between a first position and a second position to allow for selective actuation of the metering valve. In another version, the contact member's configuration may be changed to allow for selective actuation of the metering valve.
摘要翻译： 雾化装置包括壳体，容器，其包含储存包含推进剂的药物制剂的储存器和计量阀。 计量阀与储存器连通并且可移动到容器中到达预定量的药物制剂被释放的致动位置。 接触构件设置在壳体中。 在一个版本中，接触构件可在第一位置和第二位置之间移动，以允许选择性地致动计量阀。 在另一个版本中，可以改变接触构件的构造以允许选择性地致动计量阀。
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4.发明授权Unit doses, aerosols, kits, and methods for treating heart conditions by pulmonary administration 有权单位剂量，气溶胶，试剂盒和通过肺部给药治疗心脏病症的方法公开(公告)号：US08974828B2
公开(公告)日：2015-03-10
申请号：US13257249
申请日：2010-03-18
CPC分类号： A61K9/0078 , A61K31/18 , A61K31/216 , A61K31/445 , A61K31/4458 , A61K31/55 , A61K31/554 , A61K31/7076 , A61M11/00 , Y10S514/821
摘要： Methods of treating atrial arrhythmia include administering an effective amount of at least one antiarrhythmic pharmaceutical agent to a patient in need thereof, such that the at least one antiarrhythmic pharmaceutical agent first enters the heart through the pulmonary vein to the left atrium. Other methods of treating atrial arrhythmia include administering by inhalation an effective amount of at least one antiarrhythmic pharmaceutical agent to a patient in need thereof. An amount of the at least one antiarrhythmic pharmaceutical agent may peak in the coronary sinus of the heart at a time ranging from 10 seconds to 30 minutes from initiation of the administering. Unit doses, aerosols, and kits are also contemplated.
摘要翻译： 治疗心房心律失常的方法包括向有需要的患者施用有效量的至少一种抗心律失常药物，使得至少一种抗心律失常药剂首先通过肺静脉进入心脏至左心房。 治疗心房心律失常的其它方法包括通过吸入向有需要的患者施用有效量的至少一种抗心律失常药剂。 至少一种抗心律不齐药剂的量可以在从给药开始起10秒至30分钟的时间内在心脏的冠状窦中达峰。 也考虑了单位剂量，气溶胶和试剂盒。
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5.发明申请UNIT DOSES, AEROSOLS, KITS, AND METHODS FOR TREATING HEART CONDITIONS BY PULMONARY ADMINISTRATION 有权用于通过脉冲管理治疗心脏病症的单位剂量，气溶胶，溶液和方法公开(公告)号：US20120003318A1
公开(公告)日：2012-01-05
申请号：US13257249
申请日：2010-03-18
CPC分类号： A61K9/0078 , A61K31/18 , A61K31/216 , A61K31/445 , A61K31/4458 , A61K31/55 , A61K31/554 , A61K31/7076 , A61M11/00 , Y10S514/821
摘要： Methods of treating atrial arrhythmia include administering an effective amount of at least one antiarrhythmic pharmaceutical agent to a patient in need thereof, such that the at least one antiarrhythmic pharmaceutical agent first enters the heart through the pulmonary vein to the left atrium. Other methods of treating atrial arrhythmia include administering by inhalation an effective amount of at least one antiarrhythmic pharmaceutical agent to a patient in need thereof. An amount of the at least one antiarrhythmic pharmaceutical agent may peak in the coronary sinus of the heart at a time ranging from 10 seconds to 30 minutes from initiation of the administering. Unit doses, aerosols, and kits are also contemplated.
摘要翻译： 治疗心房心律失常的方法包括向有需要的患者施用有效量的至少一种抗心律失常药物，使得至少一种抗心律失常药剂首先通过肺静脉进入心脏至左心房。 治疗心房心律失常的其它方法包括通过吸入向有需要的患者施用有效量的至少一种抗心律失常药剂。 至少一种抗心律不齐药剂的量可以在从给药开始起10秒至30分钟的时间内在心脏的冠状窦中达峰。 也考虑了单位剂量，气溶胶和试剂盒。
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