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公开(公告)号：US06867201B2
公开(公告)日：2005-03-15
申请号：US10226255
申请日：2002-08-22
IPC分类号： A61K31/437 , A61K31/4375 , A61K31/439 , A61K31/46 , A61K31/517 , A61K31/519 , A61K45/06 , A61P35/00 , C07D239/94 , C07D401/10 , C07D403/10 , C07D403/14 , C07D405/12 , C07D417/14 , C07D451/02 , C07D451/04 , C07D451/06 , C07D453/02 , C07D471/04 , A61K31/33 , C07D239/00 , C07D239/70 , C07D403/00
CPC分类号： C07D401/10 , A61K45/06 , C07D239/94 , C07D403/10 , C07D405/12 , C07D451/02 , C07D453/02
摘要： The invention relates to compounds of the formula 1 and to pharmaceutically acceptable salts and solvates thereof, wherein A, X, R1, R3 and R4 are as defined herein. The invention also relates to methods of treating abnormal cell growth in mammals by administering the compounds of formula 1 and to pharmaceutical compositions for treating such disorders which contain the compounds of formula 1. The invention also relates to methods of preparing the compounds of formula 1.
摘要翻译： 本发明涉及式1的化合物及其药学上可接受的盐和溶剂化物，其中A，X，R 1，R 3和R 4如本文所定义。 本发明还涉及通过施用式1的化合物和用于治疗含有式1化合物的这种病症的药物组合物来治疗哺乳动物异常细胞生长的方法。本发明还涉及制备式1化合物的方法。
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公开(公告)号：US06541481B2
公开(公告)日：2003-04-01
申请号：US09834259
申请日：2001-04-12
申请人： John Charles Kath , Norma Jacqueline Tom , Zhengyu Liu , Eric David Cox , Joel Morris , Samit Kumar Bhattacharya
发明人： John Charles Kath , Norma Jacqueline Tom , Zhengyu Liu , Eric David Cox , Joel Morris , Samit Kumar Bhattacharya
IPC分类号： A61K31505
CPC分类号： C07D239/94 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12
摘要： The invention relates to compounds of the formula 1 and to pharmaceutically acceptable salts and solvates thereof, wherein A, X, R1, R3 and R4 are as defined herein. The invention also relates to methods of treating abnormal cell growth in mammals with administering the compounds of formula 1 and to pharmaceutical compositions for treating such disorders which contain the compounds of formula 1. The invention also relates to methods of preparing the compounds of formula 1.
摘要翻译： 本发明涉及式1的化合物及其药学上可接受的盐和溶剂合物，其中A，X，R 1，R 3和R 4如本文所定义。 本发明还涉及通过施用式1化合物治疗哺乳动物异常细胞生长的方法和用于治疗含有式1化合物的这种病症的药物组合物。本发明还涉及制备式1化合物的方法。
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公开(公告)号：US06465449B1
公开(公告)日：2002-10-15
申请号：US09488378
申请日：2000-01-20
IPC分类号： A61K3133
CPC分类号： C07D401/10 , A61K45/06 , C07D239/94 , C07D403/10 , C07D405/12 , C07D451/02 , C07D453/02
摘要： The invention relates to compounds of the formula 1 and to pharmaceutically acceptable salts and solvates thereof, wherein A, X, R1, R3 and R4 are as defined herein. The invention also relates to methods of treating abnormal cell growth in mammals by administering the compounds of formula 1 and to pharmaceutical compositions for treating such disorders which contain the compounds of formula 1. The invention also relates to methods of preparing the compounds of formula 1.
摘要翻译： 本发明涉及式1的化合物及其药学上可接受的盐和溶剂合物，其中A，X，R 1，R 3和R 4如本文所定义。 本发明还涉及通过施用式1的化合物和用于治疗含有式1化合物的这种病症的药物组合物来治疗哺乳动物异常细胞生长的方法。本发明还涉及制备式1化合物的方法。
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公开(公告)号：US06284764B1
公开(公告)日：2001-09-04
申请号：US09488350
申请日：2000-01-20
申请人： John Charles Kath , Norma Jacqueline Tom , Zhengyu Liu , Eric David Cox , Joel Morris , Samit Kumar Bhattacharya
发明人： John Charles Kath , Norma Jacqueline Tom , Zhengyu Liu , Eric David Cox , Joel Morris , Samit Kumar Bhattacharya
IPC分类号： A61K31517
CPC分类号： C07D239/94 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12
摘要： The invention relates to compounds of the formula 1 and to pharmaceutically acceptable salts and solvates thereof, wherein A, X, R1, R3 and R4 are as defined herein. The invention also relates to methods of treating abnormal cell growth in mammals with administering the compounds of formula 1 and to pharmaceutical compositions for treating such disorders which contain the compounds of formula 1. The invention also relates to methods of preparing the compounds of formula 1.
摘要翻译： 本发明涉及式1的化合物及其药学上可接受的盐和溶剂合物，其中A，X，R 1，R 3和R 4如本文所定义。 本发明还涉及通过施用式1化合物治疗哺乳动物异常细胞生长的方法和用于治疗含有式1化合物的这种病症的药物组合物。本发明还涉及制备式1化合物的方法。
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5.发明授权Process for converting a cis-trans mixture of substituted benzylidene amines into the pure cis isomer 失效将取代的亚苄基胺的顺式 - 反式混合物转化为纯的顺式异构体的方法公开(公告)号：US06878848B2
公开(公告)日：2005-04-12
申请号：US10705466
申请日：2003-11-10
IPC分类号： C07C251/24 , C07B57/00 , C07C249/02 , C07D275/04 , C07D275/06 , C07D417/00
CPC分类号： C07C251/24 , C07B2200/09 , C07C249/02
摘要： A process for interconverting a mixture of cis-trans isomers of a compound of formula I into the substantially pure cis isomer. Cis isomers of formula I are useful intermediates in the synthesis of cis isomers of benzamide piperidine compounds which exhibit activity as NK-1 receptor antagonists.
摘要翻译： 将式I化合物的顺反异构体的混合物相互转化为基本上纯的顺式异构体的方法。式I的异构体是合成苯甲酰胺哌啶化合物的顺式异构体的有用中间体，其表现出作为NK-1受体的活性 拮抗剂
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