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公开(公告)号：US06867201B2
公开(公告)日：2005-03-15
申请号：US10226255
申请日：2002-08-22
IPC分类号： A61K31/437 , A61K31/4375 , A61K31/439 , A61K31/46 , A61K31/517 , A61K31/519 , A61K45/06 , A61P35/00 , C07D239/94 , C07D401/10 , C07D403/10 , C07D403/14 , C07D405/12 , C07D417/14 , C07D451/02 , C07D451/04 , C07D451/06 , C07D453/02 , C07D471/04 , A61K31/33 , C07D239/00 , C07D239/70 , C07D403/00
CPC分类号： C07D401/10 , A61K45/06 , C07D239/94 , C07D403/10 , C07D405/12 , C07D451/02 , C07D453/02
摘要： The invention relates to compounds of the formula 1 and to pharmaceutically acceptable salts and solvates thereof, wherein A, X, R1, R3 and R4 are as defined herein. The invention also relates to methods of treating abnormal cell growth in mammals by administering the compounds of formula 1 and to pharmaceutical compositions for treating such disorders which contain the compounds of formula 1. The invention also relates to methods of preparing the compounds of formula 1.
摘要翻译： 本发明涉及式1的化合物及其药学上可接受的盐和溶剂化物，其中A，X，R 1，R 3和R 4如本文所定义。 本发明还涉及通过施用式1的化合物和用于治疗含有式1化合物的这种病症的药物组合物来治疗哺乳动物异常细胞生长的方法。本发明还涉及制备式1化合物的方法。
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公开(公告)号：US06541481B2
公开(公告)日：2003-04-01
申请号：US09834259
申请日：2001-04-12
申请人： John Charles Kath , Norma Jacqueline Tom , Zhengyu Liu , Eric David Cox , Joel Morris , Samit Kumar Bhattacharya
发明人： John Charles Kath , Norma Jacqueline Tom , Zhengyu Liu , Eric David Cox , Joel Morris , Samit Kumar Bhattacharya
IPC分类号： A61K31505
CPC分类号： C07D239/94 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12
摘要： The invention relates to compounds of the formula 1 and to pharmaceutically acceptable salts and solvates thereof, wherein A, X, R1, R3 and R4 are as defined herein. The invention also relates to methods of treating abnormal cell growth in mammals with administering the compounds of formula 1 and to pharmaceutical compositions for treating such disorders which contain the compounds of formula 1. The invention also relates to methods of preparing the compounds of formula 1.
摘要翻译： 本发明涉及式1的化合物及其药学上可接受的盐和溶剂合物，其中A，X，R 1，R 3和R 4如本文所定义。 本发明还涉及通过施用式1化合物治疗哺乳动物异常细胞生长的方法和用于治疗含有式1化合物的这种病症的药物组合物。本发明还涉及制备式1化合物的方法。
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公开(公告)号：US06465449B1
公开(公告)日：2002-10-15
申请号：US09488378
申请日：2000-01-20
IPC分类号： A61K3133
CPC分类号： C07D401/10 , A61K45/06 , C07D239/94 , C07D403/10 , C07D405/12 , C07D451/02 , C07D453/02
摘要： The invention relates to compounds of the formula 1 and to pharmaceutically acceptable salts and solvates thereof, wherein A, X, R1, R3 and R4 are as defined herein. The invention also relates to methods of treating abnormal cell growth in mammals by administering the compounds of formula 1 and to pharmaceutical compositions for treating such disorders which contain the compounds of formula 1. The invention also relates to methods of preparing the compounds of formula 1.
摘要翻译： 本发明涉及式1的化合物及其药学上可接受的盐和溶剂合物，其中A，X，R 1，R 3和R 4如本文所定义。 本发明还涉及通过施用式1的化合物和用于治疗含有式1化合物的这种病症的药物组合物来治疗哺乳动物异常细胞生长的方法。本发明还涉及制备式1化合物的方法。
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公开(公告)号：US06284764B1
公开(公告)日：2001-09-04
申请号：US09488350
申请日：2000-01-20
申请人： John Charles Kath , Norma Jacqueline Tom , Zhengyu Liu , Eric David Cox , Joel Morris , Samit Kumar Bhattacharya
发明人： John Charles Kath , Norma Jacqueline Tom , Zhengyu Liu , Eric David Cox , Joel Morris , Samit Kumar Bhattacharya
IPC分类号： A61K31517
CPC分类号： C07D239/94 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12
摘要： The invention relates to compounds of the formula 1 and to pharmaceutically acceptable salts and solvates thereof, wherein A, X, R1, R3 and R4 are as defined herein. The invention also relates to methods of treating abnormal cell growth in mammals with administering the compounds of formula 1 and to pharmaceutical compositions for treating such disorders which contain the compounds of formula 1. The invention also relates to methods of preparing the compounds of formula 1.
摘要翻译： 本发明涉及式1的化合物及其药学上可接受的盐和溶剂合物，其中A，X，R 1，R 3和R 4如本文所定义。 本发明还涉及通过施用式1化合物治疗哺乳动物异常细胞生长的方法和用于治疗含有式1化合物的这种病症的药物组合物。本发明还涉及制备式1化合物的方法。
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公开(公告)号：US06890924B2
公开(公告)日：2005-05-10
申请号：US09883752
申请日：2001-06-18
IPC分类号： A61K31/517 , A61K31/5377 , A61K31/55 , A61K39/395 , A61K45/00 , A61P5/00 , A61P5/28 , A61P35/00 , A61P43/00 , C07D239/00 , C07D239/94 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/12
CPC分类号： C07D401/12 , C07D239/94 , C07D401/14 , C07D403/12 , C07D405/14 , C07D413/12 , C07D417/12
摘要： The invention relates to compounds of the formula 1 and to pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein R1, R3, R4, R5, R11, m and p are as defined herein. The invention also relates to methods of treating abnormal cell growth in mammals by administering the compounds of formula 1 and to pharmaceutical compositions for treating such disorders which contain the compounds of formula 1. The invention also relates to methods of preparing the compounds of formula 1.
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6.发明授权公开(公告)号：US07332493B2
公开(公告)日：2008-02-19
申请号：US11079648
申请日：2005-03-14
IPC分类号： A61K31/517 , C07D239/84 , C07D401/12 , C07D403/12 , C07D417/12 , A61K31/538 , C07D413/12
CPC分类号： C07D401/12 , C07D239/94 , C07D401/14 , C07D403/12 , C07D405/14 , C07D413/12 , C07D417/12
摘要： The invention relates to compounds of the formula 1 and to pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein R1, R3, R4, R5, R11, m and p are as defined herein. The invention also relates to methods of treating abnormal cell growth in mammals by administering the compounds of formula 1 and to pharmaceutical compositions for treating such disorders which contain the compounds of formula 1. The invention also relates to methods of preparing the compounds of formula 1.
摘要翻译： 本发明涉及式1的化合物及其药学上可接受的盐，前药和溶剂合物，其中R 1，R 3，R 4， R 5，R 11，m和p如本文所定义。 本发明还涉及通过施用式1的化合物和用于治疗含有式1化合物的这种病症的药物组合物来治疗哺乳动物异常细胞生长的方法。本发明还涉及制备式1化合物的方法。
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公开(公告)号：US07585869B2
公开(公告)日：2009-09-08
申请号：US10849707
申请日：2004-05-20
申请人： Samit Kumar Bhattacharya , Jinshan Chen , Richard Damian Connell , John Charles Kath , Goss S. Kauffman , Blaise S. Lippa , Joel Morris
发明人： Samit Kumar Bhattacharya , Jinshan Chen , Richard Damian Connell , John Charles Kath , Goss S. Kauffman , Blaise S. Lippa , Joel Morris
IPC分类号： A61K31/517 , C07D239/94
CPC分类号： C07D401/12 , C07D239/94 , C07D405/14 , C07D471/04
摘要： The invention relates to compounds of formula 1 and to pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein R1, R3, R4, R11, N, Z, A, m and p are as defined herein. The invention also relates to methods of treating abnormal cell growth in mammals by administering the compounds of formula 1 and to pharmaceutical compositions for treating such disorders which contain the compounds of formula 1. The invention also relates to methods of preparing the compounds of formula 1.
摘要翻译： 本发明涉及式1化合物及其药学上可接受的盐，前药和溶剂合物，其中R1，R3，R4，R11，N，Z，A，m和p如本文所定义。 本发明还涉及通过施用式1的化合物和用于治疗含有式1化合物的这种病症的药物组合物来治疗哺乳动物异常细胞生长的方法。本发明还涉及制备式1化合物的方法。
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公开(公告)号：US08440822B2
公开(公告)日：2013-05-14
申请号：US13557049
申请日：2012-07-24
申请人： Michael Joseph Luzzio , Kevin Daniel Freeman-Cook , Samit Kumar Bhattacharya , Matthew Merrill Hayward , Catherine Angela Hulford , Christopher Lowell Autry , Xumiao Zhao , Jun Xiao , Kendra Louise Nelson
发明人： Michael Joseph Luzzio , Kevin Daniel Freeman-Cook , Samit Kumar Bhattacharya , Matthew Merrill Hayward , Catherine Angela Hulford , Christopher Lowell Autry , Xumiao Zhao , Jun Xiao , Kendra Louise Nelson
IPC分类号： C07D239/48 , C07D403/12
CPC分类号： C07D401/12 , C07D239/48 , C07D241/20 , C07D401/14 , C07D403/12 , C07D405/14 , C07D413/14 , C07D417/12 , C07D417/14 , C07D475/00
摘要： The present invention relates to a compound of the formula I wherein R1 to R6, A, B, n and m are as defined herein. Such novel sulfonyl amide derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. This invention also relates to a method of using such compounds in the treatment of abnormal cell growth in mammals, especially humans, and to pharmaceutical compositions containing such compounds.
摘要翻译： 本发明涉及式I化合物，其中R 1至R 6，A，B，n和m如本文所定义。 这种新型磺酰基酰胺衍生物可用于治疗哺乳动物中异常细胞生长，如癌症。 本发明还涉及使用这些化合物治疗哺乳动物，特别是人类异常细胞生长的方法以及含有这些化合物的药物组合物。
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公开(公告)号：US20130005964A1
公开(公告)日：2013-01-03
申请号：US13557049
申请日：2012-07-24
申请人： Michael Joseph Luzzio , Kevin Daniel Freeman-cook , Samit Kumar Bhattacharya , Matthew Merrill Hayward , Catherine Angela Hulford , Christopher Lowell Autry , Xumiao Zhao , Jun Xiao , Kendra Louise Nelson
发明人： Michael Joseph Luzzio , Kevin Daniel Freeman-cook , Samit Kumar Bhattacharya , Matthew Merrill Hayward , Catherine Angela Hulford , Christopher Lowell Autry , Xumiao Zhao , Jun Xiao , Kendra Louise Nelson
IPC分类号： C07D239/48 , C07D403/12 , C07D239/42 , C07D401/14 , C07D405/14 , C07D413/14 , C07D401/12 , C07D417/14
CPC分类号： C07D401/12 , C07D239/48 , C07D241/20 , C07D401/14 , C07D403/12 , C07D405/14 , C07D413/14 , C07D417/12 , C07D417/14 , C07D475/00
摘要： The present invention relates to a compound of the formula I wherein R1 to R6, A, B, n and m are as defined herein. Such novel sulfonyl amide derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. This invention also relates to a method of using such compounds in the treatment of abnormal cell growth in mammals, especially humans, and to pharmaceutical compositions containing such compounds.
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公开(公告)号：US20090281073A1
公开(公告)日：2009-11-12
申请号：US11722325
申请日：2005-12-15
IPC分类号： A61K31/519 , C07D471/04 , A61P35/00
CPC分类号： C07D487/08 , C07D403/14 , C07D471/04 , C07D471/10 , C07D495/04
摘要： This invention relates to compounds of Formula (I), and to pharmaceutically acceptable salts and solvates thereof, wherein Z, W, X, Y, V, R1, R2, and R3 are as defined herein. The invention also relates to methods of treating abnormal cell growth in mammals by administering the compounds of Formula (I) and to pharmaceutical compositions for treating such disorders which contain the compounds of Formula (I). The invention also relates to methods of preparing the compounds of Formula (I).
摘要翻译： 本发明涉及式（I）化合物及其药学上可接受的盐和溶剂合物，其中Z，W，X，Y，V，R 1，R 2和R 3如本文所定义。 本发明还涉及通过施用式（I）化合物和用于治疗含有式（I）化合物的这种病症的药物组合物来治疗哺乳动物异常细胞生长的方法。 本发明还涉及制备式（I）化合物的方法。
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