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公开(公告)号：US07282358B2
公开(公告)日：2007-10-16
申请号：US10661262
申请日：2003-09-12
申请人： John Coogan , Barry Ressler
发明人： John Coogan , Barry Ressler
CPC分类号： H01J61/125 , A61M1/3681 , A61M1/3683 , C12N13/00
摘要： Methods, systems and apparatus for photo-processing of fluids, particularly complex fluids, such as blood products, pharmaceuticals, injectables and vaccines, are provided. The disclosed methods and systems employ non-laser light source(s) to generate monochromatic light energy, preferably in the range of 260 nm to 310 nm, for fluid treatment. Advantageous processing regimens and/or adjunct additives and/or agents may also be used to achieve desired and/or enhanced results, e.g., inactivation of pathogens, bacteria and/or viruses, modulation of immune response, and/or leukoreduction. Particularly preferred embodiments include specific wavelengths, novel temperature control systems and geometric/structural arrangements that provide enhanced processing results and/or efficiencies. The disclosed methods, systems and apparatus achieve desirable results in a broad range of diagnostic, therapeutic and treatment applications, and generally provide enhanced operating efficiencies and/or processing results in application modalities that employ a broad range of photo-activated and/or photo-responsive materials and/or compounds.
摘要翻译： 提供了用于流体，特别是复杂流体如血液制品，药物，注射剂和疫苗的光加工的方法，系统和装置。 所公开的方法和系统使用非激光光源来产生单色光能，优选在260nm至310nm的范围内用于流体处理。 还可以使用有利的加工方案和/或辅助添加剂和/或试剂来实现期望和/或增强的结果，例如病原体，细菌和/或病毒的失活，免疫应答的调节和/或白细胞减退。 特别优选的实施方案包括特定的波长，新的温度控制系统和提供增强的处理结果和/或效率的几何/结构布置。 公开的方法，系统和装置在广泛的诊断，治疗和治疗应用中实现期望的结果，并且通常在应用模式中提供增强的操作效率和/或处理结果，其应用范围广泛的光激活和/ 响应材料和/或化合物。
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公开(公告)号：US5626768A
公开(公告)日：1997-05-06
申请号：US569830
申请日：1995-12-07
摘要： An apparatus and a method for killing bacteria within an opaque liquid. The opaque liquid is moved along a high power ultraviolet radiation surface at a velocity which causes turbulent flow in the liquid. The turbulent flow mixes the opaque liquid so that all the liquid is exposed to the radiation even though the radiation does not penetrate the liquid to any significant depth. One embodiment of the invention moves the liquid in a serpentine path between multiple planar lamps which radiate UV from both planar surfaces.
摘要翻译： 用于杀死不透明液体内的细菌的装置和方法。 不透明液体沿着高功率的紫外线辐射表面以引起液体中的湍流的速度移动。 湍流混合不透明液体，使得即使辐射不将液体渗透到任何明显的深度，所有液体也暴露于辐射。 本发明的一个实施例使液体在从两个平面表面辐射UV的多个平面灯之间的蛇形路径中移动。
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公开(公告)号：US07381976B2
公开(公告)日：2008-06-03
申请号：US09805610
申请日：2001-03-13
申请人： John J. Coogan, Jr. , Barry Ressler
发明人： John J. Coogan, Jr. , Barry Ressler
CPC分类号： H01J61/125 , A61M1/3681 , A61M1/3683 , C12N13/00
摘要： Methods, systems and apparatus for photo-processing of fluids, particularly complex fluids, such as blood products, pharmaceuticals, injectables and vaccines, are provided. The disclosed methods and systems employ non-laser light source(s) to generate monochromatic light energy, preferably in the range of 260 nm to 310 nm, for fluid treatment. Advantageous processing regimens and/or adjunct additives and/or agents may also be used to achieve desired and/or enhanced results, e.g., inactivation of pathogens, bacteria and/or viruses, modulation of immune response, and/or leukoreduction. Particularly preferred embodiments include novel temperature control systems and geometric/structural arrangements that provide enhanced processing results and/or efficiencies. The disclosed methods, systems and apparatus achieve desirable results in a broad range of diagnostic, therapeutic and treatment applications, and generally provide enhanced operating efficiencies and/or processing results in application modalities that employ a broad range of photo-activated and/or photo-responsive materials and/or compounds.
摘要翻译： 提供了用于流体，特别是复杂流体如血液制品，药物，注射剂和疫苗的光加工的方法，系统和装置。 所公开的方法和系统使用非激光光源来产生单色光能，优选在260nm至310nm的范围内用于流体处理。 还可以使用有利的加工方案和/或辅助添加剂和/或试剂来实现期望和/或增强的结果，例如病原体，细菌和/或病毒的失活，免疫应答的调节和/或白细胞减退。 特别优选的实施例包括提供增强的处理结果和/或效率的新型温度控制系统和几何/结构布置。 公开的方法，系统和装置在广泛的诊断，治疗和治疗应用中实现期望的结果，并且通常在应用模式中提供增强的操作效率和/或处理结果，其应用范围广泛的光激活和/ 响应材料和/或化合物。
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公开(公告)号：US20050173652A1
公开(公告)日：2005-08-11
申请号：US11056698
申请日：2005-02-11
申请人： Barry Ressler
发明人： Barry Ressler
CPC分类号： A61L2/10 , A23B4/015 , A23L3/28 , A61L2/26 , A61L12/063 , A61L2202/14
摘要： System and method for sterilization, using UV light source(s), of products, e.g., polymer-based products, whether positioned within or external to their packaging, using monochromatic, continuous wave, high-intensity, incoherent light in single and/or multiple light source configurations. The treatment system(s) and method(s) may be used for sterilization of alternative products, including, for example, food products such as meat and poultry, enteral and/or parenteral solutions and systems, and the like.
摘要翻译： 使用紫外光源的产品（例如基于聚合物的产品）的无菌定位在其包装内或外部的灭菌系统和方法，使用单色，连续波，高强度，非相干光在单个和/或 多种光源配置。 治疗系统和方法可以用于替代产品的灭菌，包括例如肉和禽类等食品，肠内和/或肠胃外溶液和系统等。
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5.发明申请公开(公告)号：US20090274576A1
公开(公告)日：2009-11-05
申请号：US11654475
申请日：2007-01-17
申请人： Barry Ressler
发明人： Barry Ressler
摘要： Packaging materials and containers may be treated with sterilization dosages internally and externally using monochromatic, continuous wave, high-intensity, incoherent light in single and/or multiple light source configurations. The treatment systems and methods preserve physical and performance properties of the packaging/container while achieving a desired level of sterilization. The sterilized materials may be adapted for extended shelf life (ESL) products. The disclosed treatment systems and methods may also be used for sterilization of food and beverage products (either prepackaged or post packaged), medicines, pharmaceuticals, vitamins, infusion products, clinical and/or non-clinical solutions and systems, enteral and/or parenteral solutions and systems, and the like.
摘要翻译： 包装材料和容器可以使用单个和/或多个光源配置中的单色，连续波，高强度，非相干光在内部和外部的灭菌剂量进行处理。 处理系统和方法保持包装/容器的物理性能和性能，同时达到所需的灭菌水平。 灭菌的材料可适用于延长保质期（ESL）产品。 公开的治疗系统和方法也可以用于食品和饮料产品（预包装或后包装），药物，药物，维生素，输注产品，临床和/或非临床解决方案和系统，肠内和/或肠胃外 解决方案和系统等。
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公开(公告)号：US07217936B2
公开(公告)日：2007-05-15
申请号：US11056698
申请日：2005-02-11
申请人： Barry Ressler
发明人： Barry Ressler
CPC分类号： A61L2/10 , A23B4/015 , A23L3/28 , A61L2/26 , A61L12/063 , A61L2202/14
摘要： System and method for sterilization, using UV light source(s), of products, e.g., polymer-based products, whether positioned within or external to their packaging, using monochromatic, continuous wave, high-intensity, incoherent light in single and/or multiple light source configurations. The treatment system(s) and method(s) may be used for sterilization of alternative products, including, for example, food products such as meat and poultry, enteral and/or parenteral solutions and systems, and the like.
摘要翻译： 使用紫外光源的产品（例如基于聚合物的产品）的无菌定位在其包装内或外部的灭菌系统和方法，使用单色，连续波，高强度，非相干光在单个和/或 多种光源配置。 治疗系统和方法可以用于替代产品的灭菌，包括例如肉和禽类等食品，肠内和/或肠胃外溶液和系统等。
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7.发明授权公开(公告)号：US08125333B2
公开(公告)日：2012-02-28
申请号：US12475902
申请日：2009-06-01
CPC分类号： A61L2/10 , A61L2/24 , A61L2202/181 , A61L2202/21 , B65B55/08
摘要： The present disclosure provides for methods, systems and apparatus for monochromatic UV light sterilization of container systems and/or container-packaged products. More particularly, the present disclosure provides for improved methods, systems and apparatus for monochromatic UV light sterilization of liquid and/or solid products/solutions and/or packaging/container systems for liquid and/or solid products/solutions (e.g., parenteral pharmaceutical products/solutions and/or packaging/container systems for parenteral pharmaceutical products/solutions). In exemplary embodiments, the present disclosure provides for improved systems and methods for the sterilization of container systems and/or container-packaged products using monochromatic, continuous wave, high-intensity, incoherent light in multiple light source configurations, wherein such sterilization regimen achieves a desired sterilization level without negatively affecting the physical properties of the package/container systems and/or the efficacy of the underlying products/systems.
摘要翻译： 本公开提供了用于容器系统和/或容器包装产品的单色UV光灭菌的方法，系统和装置。 更具体地，本公开提供用于液体和/或固体产品/溶液和/或用于液体和/或固体产品/溶液的包装/容器系统的单色UV光灭菌的改进方法，系统和装置（例如，肠胃外药物产品 /解决方案和/或用于肠胃外药物产品/解决方案的包装/容器系统）。 在示例性实施例中，本公开提供了用于在多个光源配置中使用单色，连续波，高强度，非相干光来灭菌容器系统和/或容器封装产品的改进的系统和方法，其中这种灭菌方案实现 所需的灭菌水平，而不会不利地影响包装/容器系统的物理性质和/或底层产品/系统的功效。
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公开(公告)号：US20100007492A1
公开(公告)日：2010-01-14
申请号：US12475902
申请日：2009-06-01
CPC分类号： A61L2/10 , A61L2/24 , A61L2202/181 , A61L2202/21 , B65B55/08
摘要： The present disclosure provides for methods, systems and apparatus for monochromatic UV light sterilization of container systems and/or container-packaged products. More particularly, the present disclosure provides for improved methods, systems and apparatus for monochromatic UV light sterilization of liquid and/or solid products/solutions and/or packaging/container systems for liquid and/or solid products/solutions (e.g., parenteral pharmaceutical products/solutions and/or packaging/container systems for parenteral pharmaceutical products/solutions). In exemplary embodiments, the present disclosure provides for improved systems and methods for the sterilization of container systems and/or container-packaged products using monochromatic, continuous wave, high-intensity, incoherent light in multiple light source configurations, wherein such sterilization regimen achieves a desired sterilization level without negatively affecting the physical properties of the package/container systems and/or the efficacy of the underlying products/systems.
摘要翻译： 本公开提供了用于容器系统和/或容器包装产品的单色UV光灭菌的方法，系统和装置。 更具体地，本公开提供用于液体和/或固体产品/溶液和/或用于液体和/或固体产品/溶液的包装/容器系统的单色UV光灭菌的改进方法，系统和装置（例如，肠胃外药物产品 /解决方案和/或用于肠胃外药物产品/解决方案的包装/容器系统）。 在示例性实施例中，本公开提供了用于在多个光源配置中使用单色，连续波，高强度，非相干光来灭菌容器系统和/或容器封装产品的改进的系统和方法，其中这种灭菌方案实现 所需的灭菌水平，而不会不利地影响包装/容器系统的物理性质和/或底层产品/系统的功效。
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