Enzymatic decontamination
    2.
    发明授权
    Enzymatic decontamination 有权
    酶消毒

    公开(公告)号:US08080404B1

    公开(公告)日:2011-12-20

    申请号:US11328477

    申请日:2006-01-09

    摘要: Compositions and methods for enzymatic decontamination by inactivation of Hazardous agents are provided. Hazardous agents of microbial and chemical origin can be neutralized by H2O2. The methods described herein provide for enzymatic production of H2O2 in situ using oxidoreductase enzymes that use oxygen as an acceptor and their alcohol substrates. The enzymatically produced H2O2 and corresponding aldehydes have potent antimicrobial properties. The enzymatically produced H2O2 also can detoxify chemical agents in situ. The decontaminating power of the oxidoreductase enzymes that use oxygen as an acceptor may be amplified by addition of reagents, such as acetyl donors or base catalysts that, in the presence of H2O2, yield peroxy acid derivatives and hydroperoxy anions. Such derivatives can neutralize biological and chemical agents, thus providing a broadly applicable decontamination method. In addition, catalytic production of H2O2 in situ results in controlled synthesis of decontamination reagents at their point of use, mitigating the need to store, transport and dispose of hydrogen peroxide solutions in the field.

    摘要翻译: 提供了通过灭活有害物质进行酶消除的组合物和方法。 微生物和化学来源的有害物质可被H 2 O 2中和。 本文所述的方法提供使用氧作为受体及其醇底物的氧化还原酶酶原生成H 2 O 2。 酶促产生的H 2 O 2和相应的醛具有有效的抗微生物性质。 酶法制备的H 2 O 2也可以原位解毒化学试剂。 使用氧作为受体的氧化还原酶的去污能力可以通过加入试剂来扩增,例如在H 2 O 2存在下产生过氧酸衍生物和氢过氧化物阴离子的乙酰基供体或碱催化剂。 这样的衍生物可以中和生物和化学试剂,从而提供广泛适用的净化方法。 此外,H 2 O 2的原位催化生产在其使用点导致去污试剂的可控合成,减少了在现场存储,运输和处理过氧化氢溶液的需要。