公开(公告)号：US20110275079A1

公开(公告)日：2011-11-10

申请号：US12742920

申请日：2008-11-13

申请人： John F. Palma ,  John W. Backus ,  Yixin Wang ,  Jack X. Yu ,  Yi Zhang ,  Tatiana Vener ,  Carlo Derecho ,  Dong U. Lee

发明人： John F. Palma ,  John W. Backus ,  Yixin Wang ,  Jack X. Yu ,  Yi Zhang ,  Tatiana Vener ,  Carlo Derecho ,  Dong U. Lee

IPC分类号： C12Q1/68 ,  G01N33/53

CPC分类号： C12Q1/6883 ,  C12Q2600/112 ,  C12Q2600/156 ,  C12Q2600/158 ,  G01N33/53 ,  G01N33/6893 ,  G16B25/00 ,  G16B40/00 ,  G16H50/20 ,  Y02A90/26

摘要： Methods are disclosed for the identification of gene sets that are differentially expressed in PBMCs of patients diagnosed with a pre-diabetic disease state and overt type II diabetes. 3 gene and 10 gene signatures are shown to accurately predict a diabetic disease state in a patient. The application also described kits for the rapid diagnosis of diabetic disease states in patients at a point of care facility.

摘要翻译： 公开了用于鉴定在诊断患有糖尿病前状态和明显II型糖尿病的患者的PBMC中差异表达的基因组的方法。 3基因和10个基因特征被证明准确预测患者的糖尿病状态。 该应用还描述了在护理设施点的患者中快速诊断糖尿病疾病状态的试剂盒。