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    COPY NUMBER ALTERATIONS THAT PREDICT METASTATIC CAPABILITY OF HUMAN BREAST CANCER
    3.
    发明申请
    COPY NUMBER ALTERATIONS THAT PREDICT METASTATIC CAPABILITY OF HUMAN BREAST CANCER 审中-公开
    预测人乳腺癌的分类能力的复制编号

    公开(公告)号：US20090155805A1

    公开(公告)日：2009-06-18

    申请号：US12335162

    申请日：2008-12-15

    申请人： Yi Zhang ,  Jack X. Yu ,  Yuqui Jiang ,  Yixin Wang

    发明人： Yi Zhang ,  Jack X. Yu ,  Yuqui Jiang ,  Yixin Wang

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/6827

    摘要： Disclosed in this specification is a method of defining chromosome regions of prognostic value by summarizing the significance of all SNPs (single nucleotide polymorphism) in a predetermined section of a chromosome to define chromosome regions of prognostic value. Based on the SNPs in specified genes, a more accurate prognosis for breast cancer may be provided.

    摘要翻译： 在本说明书中公开的是通过总结染色体预定部分中所有SNP（单核苷酸多态性）的意义来定义预后价值的染色体区域来定义预后价值的染色体区域的方法。 基于特定基因的SNP，可以提供更准确的乳腺癌预后。

    Laser microdissection and microarray analysis of breast tumors reveal estrogen receptor related genes and pathways
    4.
    发明申请
    Laser microdissection and microarray analysis of breast tumors reveal estrogen receptor related genes and pathways 审中-公开
    乳腺肿瘤的激光显微切割和微阵列分析显示雌激素受体相关基因和途径

    公开(公告)号：US20080305959A1

    公开(公告)日：2008-12-11

    申请号：US11398340

    申请日：2006-04-04

    申请人： Yixin Wang ,  Jack X. Yu ,  Yugiu Jiang ,  Fei Yang

    发明人： Yixin Wang ,  Jack X. Yu ,  Yugiu Jiang ,  Fei Yang

    IPC分类号： C40B30/04 ,  C12Q1/68 ,  C07H21/04 ,  C40B40/08

    CPC分类号： C12Q1/6806 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/154 ,  C12Q2600/158

    摘要： About 70% to 80% of breast cancers express estrogen receptor-α (ERα), and estrogens play important roles in the development and growth of hormone-dependent tumors. Together with lymph node metastasis, tumor size and histological grade, ER status is considered one of the prognostic factors in breast cancer, and an indicator for hormonal treatment. 147 genes and 112 genes with significant P-value and having significant differential expression between ER+ and ER− tumors were identified from the LCM data set and bulk tissue data set, respectively. 61 genes were found to be common in both data sets, while 85 genes were unique to the LCM data set and 51 genes were present only in the bulk tumor data set. Pathway analysis with the 85 genes using Gene Ontology suggested that genes involved in endocytosis, ceramide generation, Ras/ERK/Ark cascade, and JAT-STAT pathway may play roles related to ER. The gene profiling with LCM-captured tumor cells provides a unique approach to characterize and study epithelial tumor cells and to gain an insight into signaling pathways associated with ER.

    摘要翻译： 大约70％至80％的乳腺癌表达雌激素受体α（ERalpha），雌激素在激素依赖性肿瘤的发育和生长中起重要作用。 与淋巴结转移，肿瘤大小和组织学分级一起，ER状态被认为是乳腺癌的预后因素之一，也是激素治疗的指标。 分别从LCM数据集和体组织数据集中分别鉴定了147个基因和112个具有显着P值并且在ER +和ER-肿瘤之间具有显着差异表达的基因。 发现61个基因在两个数据集中都是常见的，而85个基因是LCM数据集所独有的，51个基因仅存在于肿瘤数据集中。 使用Gene Ontology的85个基因的途径分析表明，参与内吞作用，神经酰胺生成，Ras / ERK / Ark级联和JAT-STAT途径的基因可能发挥与ER有关的作用。 用LCM捕获的肿瘤细胞进行基因分析提供了表征和研究上皮肿瘤细胞的独特方法，并获得了与ER相关的信号通路的洞察。

    Prediction of response to docetaxel therapy based on the presence of TMPRSSG2:ERG fusion in circulating tumor cells
    5.
    发明申请
    Prediction of response to docetaxel therapy based on the presence of TMPRSSG2:ERG fusion in circulating tumor cells 审中-公开
    基于TMPRSSG2：ERG融合在循环肿瘤细胞中的存在对多西紫杉醇治疗的预测

    公开(公告)号：US20110166030A1

    公开(公告)日：2011-07-07

    申请号：US12924506

    申请日：2010-09-28

    申请人： Yixin Wang ,  Yuqiu Jiang ,  John F. Palma

    发明人： Yixin Wang ,  Yuqiu Jiang ,  John F. Palma

    IPC分类号： C40B30/00

    CPC分类号： G01N33/57434 ,  G01N2800/52

    摘要： A method for predicting with high specificity from RTPCR detected markers if a patent is likely to respond to docetaxel treatment is disclosed. RTPCR detects the presence of absence of certain mutations due to fusion events. Together, with other protein markers, additional stratification is possible to identify patents suited for docetaxel therapy as opposed to for alternative treatments.

    摘要翻译： 公开了一种如果专利可能对多西紫杉醇治疗作出反应，则从RTPCR检测的标记物以高特异性预测的方法。 RTPCR检测由于融合事件而不存在某些突变。 与其他蛋白质标记一起，额外的分层可以鉴定适合多西他赛治疗的专利，而不是替代治疗。

    SLEEP APNEA MOUTH GUARD SENSOR
    8.
    发明申请
    SLEEP APNEA MOUTH GUARD SENSOR 有权

    公开(公告)号：US20230067474A1

    公开(公告)日：2023-03-02

    申请号：US17887066

    申请日：2022-08-12

    申请人： Yixin Wang ,  David Xudong Wang

    发明人： Yixin Wang ,  David Xudong Wang

    IPC分类号： A61B5/11 ,  A61B5/0205 ,  A61B5/00 ,  A61B5/08

    摘要： The present invention is directed to a sensor device detecting movement of mouth or tongue associated with bruxism and/or sleep apnea. The present invention is also directed to a system for treating sleep apnea in a patient in need thereof, comprising a sensing component and a stimulation component, the sensing component comprising one or more wireless sensors for collecting one or more vital signs of the patient and/or tongue muscle movements of the patient, the sensing component being in wireless communication with a control system, and wherein the stimulation component comprises (i) an implantable body configured to deliver energy to one of a nerve or muscle, and (ii) a wearable appliance inductively coupled to the implanted body, the wearable portion configured to receive signals from the control system, wherein the sensing component comprises the sensor device of the present invention.

    REMOTE NODE FOR WAVELENGTH-DIVISION-MULTIPLEXED PASSIVE OPTICAL NETWORK
    9.
    发明申请
    REMOTE NODE FOR WAVELENGTH-DIVISION-MULTIPLEXED PASSIVE OPTICAL NETWORK 失效
    用于波长多路复用被动光网络的远程节点

    公开(公告)号：US20110222857A1

    公开(公告)日：2011-09-15

    申请号：US12935805

    申请日：2009-03-31

    申请人： Yang Jing Wen ,  Zhaowen Xu ,  Xiaofei Cheng ,  Yixin Wang

    发明人： Yang Jing Wen ,  Zhaowen Xu ,  Xiaofei Cheng ,  Yixin Wang

    IPC分类号： H04J14/02

    CPC分类号： H04B10/27 ,  H04B10/272 ,  H04J14/0282

    摘要： A remote node for a wavelength-division-multiplexed passive optical network (WDM PON). The remote node comprises means for receiving uplink optical signals from one or more optical network units of the WDM PON; a broadband reflector for reflecting a self-seeding portion of the respective uplink optical signals to the respective uplink light sources; and wherein the reflector comprises a gain medium and is configured for receiving a pump optical signal from a central office of the WDM PON for amplifying the self seeding portion of the respective uplink optical signal.

    摘要翻译： 用于波分复用无源光网络（WDM PON）的远程节点。 远程节点包括用于从WDM PON的一个或多个光网络单元接收上行光信号的装置; 宽带反射器，用于将各个上行链路光信号的自播种部分反射到相应的上行链路光源; 并且其中所述反射器包括增益介质，并且被配置为从所述WDM PON的中心局接收泵浦光信号，用于放大所述相应上行链路光信号的自播种部分。

    BREAST CANCER PROGNOSTICS
    10.
    发明申请
    BREAST CANCER PROGNOSTICS 有权
    乳腺癌预后

    公开(公告)号：US20100009861A1

    公开(公告)日：2010-01-14

    申请号：US11923888

    申请日：2007-10-25

    申请人： Yixin Wang

    发明人： Yixin Wang

    IPC分类号： C40B30/04 ,  C12Q1/68

    CPC分类号： C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/158 ,  Y10T436/25

    摘要： A method of providing a prognosis of breast cancer is conducted by analyzing the expression of a group of genes. Gene expression profiles in a variety of medium such as microarrays are included as are kits that contain them.

    摘要翻译： 通过分析一组基因的表达来进行提供乳腺癌预后的方法。 包括微阵列在内的各种培养基中的基因表达谱也包含在其中。