公开(公告)号：US20110275079A1

公开(公告)日：2011-11-10

申请号：US12742920

申请日：2008-11-13

申请人： John F. Palma ,  John W. Backus ,  Yixin Wang ,  Jack X. Yu ,  Yi Zhang ,  Tatiana Vener ,  Carlo Derecho ,  Dong U. Lee

发明人： John F. Palma ,  John W. Backus ,  Yixin Wang ,  Jack X. Yu ,  Yi Zhang ,  Tatiana Vener ,  Carlo Derecho ,  Dong U. Lee

IPC分类号： C12Q1/68 ,  G01N33/53

CPC分类号： C12Q1/6883 ,  C12Q2600/112 ,  C12Q2600/156 ,  C12Q2600/158 ,  G01N33/53 ,  G01N33/6893 ,  G16B25/00 ,  G16B40/00 ,  G16H50/20 ,  Y02A90/26

摘要： Methods are disclosed for the identification of gene sets that are differentially expressed in PBMCs of patients diagnosed with a pre-diabetic disease state and overt type II diabetes. 3 gene and 10 gene signatures are shown to accurately predict a diabetic disease state in a patient. The application also described kits for the rapid diagnosis of diabetic disease states in patients at a point of care facility.

摘要翻译： 公开了用于鉴定在诊断患有糖尿病前状态和明显II型糖尿病的患者的PBMC中差异表达的基因组的方法。 3基因和10个基因特征被证明准确预测患者的糖尿病状态。 该应用还描述了在护理设施点的患者中快速诊断糖尿病疾病状态的试剂盒。

公开(公告)号：US20090155805A1

公开(公告)日：2009-06-18

申请号：US12335162

申请日：2008-12-15

申请人： Yi Zhang ,  Jack X. Yu ,  Yuqui Jiang ,  Yixin Wang

发明人： Yi Zhang ,  Jack X. Yu ,  Yuqui Jiang ,  Yixin Wang

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6827

摘要： Disclosed in this specification is a method of defining chromosome regions of prognostic value by summarizing the significance of all SNPs (single nucleotide polymorphism) in a predetermined section of a chromosome to define chromosome regions of prognostic value. Based on the SNPs in specified genes, a more accurate prognosis for breast cancer may be provided.

摘要翻译： 在本说明书中公开的是通过总结染色体预定部分中所有SNP（单核苷酸多态性）的意义来定义预后价值的染色体区域来定义预后价值的染色体区域的方法。 基于特定基因的SNP，可以提供更准确的乳腺癌预后。

公开(公告)号：US20090192045A1

公开(公告)日：2009-07-30

申请号：US12355906

申请日：2009-01-19

申请人： Yuqiu Jiang ,  Yi Zhang ,  Yixin Wang

发明人： Yuqiu Jiang ,  Yi Zhang ,  Yixin Wang

IPC分类号： C40B30/00 ,  C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/158 ,  C12Q2600/16

摘要： Kits and articles include reagents for conducting a seven gene assay to stage colon cancer as Stage II or Stage III colon cancer.

摘要翻译： 试剂盒和制品包括用于进行七个基因测定以分期结肠癌作为II期或III期结肠癌的试剂。

公开(公告)号：US20070031873A1

公开(公告)日：2007-02-08

申请号：US11497180

申请日：2006-08-01

申请人： Yixin Wang ,  Yi Zhang ,  David Atkins ,  Anieta Sieuwerts ,  Marcel Smid ,  Jan Klijn ,  John Martens ,  John Foekens

发明人： Yixin Wang ,  Yi Zhang ,  David Atkins ,  Anieta Sieuwerts ,  Marcel Smid ,  Jan Klijn ,  John Martens ,  John Foekens

IPC分类号： C12Q1/68 ,  G01N33/574

CPC分类号： G01N33/57415 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/154 ,  C12Q2600/158 ,  G16B25/00 ,  G16B40/00

摘要： A method of providing predicting relapse of breast cancer in bone is conducted by analyzing the expression of a group of genes. Gene expression profiles in a variety of medium such as microarrays are included as are kits that contain them.

摘要翻译： 通过分析一组基因的表达来进行骨骼中预测乳腺癌复发的方法。 包括微阵列在内的各种培养基中的基因表达谱也包含在其中。

公开(公告)号：US20050053682A1

公开(公告)日：2005-03-10

申请号：US10658194

申请日：2003-09-10

申请人： Yi Zhang ,  Yi Zhang ,  Qingjiang Wu

发明人： Yi Zhang ,  Yi Zhang ,  Qingjiang Wu

IPC分类号： A61K31/365 ,  A61K31/366 ,  A61K31/37 ,  A61K31/4741 ,  A61K36/75 ,  A61K35/78

CPC分类号： A61K36/75

摘要： Methods and uses pertaining to the oral treatment of anorectal conditions in a man or woman in need of such treatment are described, which comprises treatment with an orally effective amount of an extract of Cortex Dictamni in unit dosage form in association with one or more carriers or excipients.

摘要翻译： 描述了与需要这种治疗的男性或女性口腔治疗肛门直肠病症有关的方法和用途，其包括以口服有效量的单位剂量形式的皮质硬脑膜炎提取物与一种或多种载体或 赋形剂。

公开(公告)号：US20230138190A1

公开(公告)日：2023-05-04

申请号：US18091673

申请日：2022-12-30

申请人： Yi Zhang ,  Maruti Gupta Hyde ,  Ziyi LI ,  Vaibhav Singh ,  Christian Maciocco ,  Jaemin Han

发明人： Yi Zhang ,  Maruti Gupta Hyde ,  Ziyi LI ,  Vaibhav Singh ,  Christian Maciocco ,  Jaemin Han

IPC分类号： H04W52/02 ,  H04W36/24

摘要： An apparatus and system of providing energy saving in a network are described. A target node receives, from a source node, a handover request to handover a UE due to at least one of entry of the source node into a power saving state or mobility optimization. In response, the target node transmits a relative energy efficiency value of Bits per Joule and periodic feedback related to a status of the UE for training an AI/ML energy saving model and stops the feedback in response to a stop parameter being met. The stop parameter is a first of: a predicted period of the source node to stay in the power saving state or time for a UE to connect to the target node, a percentage of UEs handed over that enter an idle or inactive state, and a percentage of UEs handed over that are further handed to another node.

公开(公告)号：US20230015807A1

公开(公告)日：2023-01-19

申请号：US17859542

申请日：2022-07-07

申请人： Yi Zhang

发明人： Yi Zhang

IPC分类号： A61N7/02

摘要： The present disclosure relates to transcranial ultrasound systems, devices, and methods which are used for treatment rather than for imaging or medical diagnosis. In accordance with one aspect, a system for applying ultrasound energy includes at least three ultrasound applicators configured to be secured against a head of a person and configured to apply ultrasound energy to the head of the person when activated, and a controller configured to control activation and deactivation of the at least three ultrasound applicators based on a predetermined treatment sequence.

公开(公告)号：USD965873S1

公开(公告)日：2022-10-04

申请号：US29732965

申请日：2020-04-29

申请人： Yi Zhang

设计人： Yi Zhang

公开(公告)号：US11124527B2

公开(公告)日：2021-09-21

申请号：US15579830

申请日：2016-06-03

申请人： Syros Pharmaceuticals, Inc. ,  Christopher Roberts ,  Yi Zhang ,  Francis Beaumier ,  Luce Lépissier

发明人： Jason J. Marineau ,  Peter B. Rahl ,  Kevin Sprott ,  Stephane Ciblat ,  Boubacar Sow ,  Robin Larouche-Gauthier ,  Lauren Berstler ,  Christopher Roberts ,  Yi Zhang ,  Francis Beaumier ,  Luce Lépissier

IPC分类号： C07D513/04 ,  A61P35/00 ,  C07D495/04

摘要： The present invention provides novel compounds of Formulas (I) and (II) and pharmaceutically acceptable salts, solvates, hydrates, tautomers, stereoisomers, isotopically labeled derivatives, and compositions thereof. Also provided are methods and kits involving the compounds or compositions for treating or preventing proliferative diseases, e.g., cancers (e.g., breast cancer, prostate cancer, lymphoma, lung cancer, pancreatic cancer, ovarian cancer, neuroblastoma, or colorectal cancer), benign neoplasms, angio genesis, inflammatory diseases, fibrosis (e.g., polycystic kidney disease), autoinflammatory diseases, and autoimmune diseases in a subject.

公开(公告)号：US10893824B2

公开(公告)日：2021-01-19

申请号：US13306343

申请日：2011-11-29

申请人： Qi An ,  Yi Zhang

发明人： Qi An ,  Yi Zhang

IPC分类号： A61B5/08 ,  A61B5/053 ,  G16H50/20 ,  A61B7/00 ,  A61B5/0205 ,  A61B7/04 ,  A61B5/024 ,  G06F19/00

摘要： A system and method for automatically analyzing heart failure in a patient, including collecting physiological data from a patient using at least a first sensor and a second sensor to collect two or more sensor measurements, and calculating a first composite value based on at least a first sensor measurement wherein the first composite value is an indication of a likelihood that the patient's heart failure status has changed. If the first composite value is outside of a first specified range, then a second composite value is calculated based on at least a second sensor measurement, wherein the second composite value is an indication of a likelihood that the patient's heart failure status has changed. If the second composite value is outside of a second specified range, then an alert of change in heart failure status is generated.