公开(公告)号：US20080107630A1

公开(公告)日：2008-05-08

申请号：US11697394

申请日：2007-04-06

申请人： John G. Hay ,  Jin Cheng ,  Harald Sauthoff

发明人： John G. Hay ,  Jin Cheng ,  Harald Sauthoff

IPC分类号： A61K39/12 ,  A61P35/00 ,  C12N9/50

CPC分类号： C12N15/86 ,  A61K35/761 ,  A61K38/00 ,  C12N7/00 ,  C12N9/6491 ,  C12N2710/10332 ,  C12N2710/10343 ,  A61K2300/00

摘要： The present invention discloses a method of treating cancer in a subject. This involves co-administering a replicating virus and a matrix metalloproteinase to the subject under conditions effective to treat cancer. It also relates to a method of enhancing the delivery to and distribution within a tumor mass of therapeutic viruses. This involves co-administering a replicating virus and a matrix metalloproteinase to the tumor mass under conditions effective to enhance the delivery to and distribution within the tumor mass of therapeutic viruses. Another aspect relates to a cancer therapeutic. This involves a replicating virus and a matrix metalloproteinase.

摘要翻译： 本发明公开了一种治疗受试者的癌症的方法。 这涉及在有效治疗癌症的条件下向受试者共同施用复制病毒和基质金属蛋白酶。 本发明还涉及增强治疗性病毒肿瘤块内的传递和分布的方法。 这涉及在有效增强在治疗性病毒的肿瘤块内递送和分布的条件下，将复制病毒和基质金属蛋白酶共同施用于肿瘤块。 另一方面涉及癌症治疗剂。 这涉及复制病毒和基质金属蛋白酶。