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25 条记录 (耗时 0.026 秒)

    Preparation of thiocycloalkno [3,2-b] pyridines
    6.
    发明授权
    Preparation of thiocycloalkno [3,2-b] pyridines 失效
    硫代环烷基[3,2-b]吡啶的制备

    公开(公告)号：US4879384A

    公开(公告)日：1989-11-07

    申请号：US220134

    申请日：1988-06-15

    申请人： Charles F. Schwender ,  John H. Dodd

    发明人： Charles F. Schwender ,  John H. Dodd

    IPC分类号： C07D495/04

    CPC分类号： C07D495/04

    摘要： Novel substituted thiacycloalkeno [3,2-b] pyridines are described. These compounds are useful as calcium channel antagonists with cardiovascular, antiasthmatic and antibronchoconstrictor activity.

    摘要翻译： 描述了新的取代的硫杂环己烯并[3,2-b]吡啶。 这些化合物可用作具有心血管，抗哮喘和抗纤维支配作用的钙通道拮抗剂。

    Substituted thiacycloalkeno [3,2-b] pyridines
    7.
    发明授权
    Substituted thiacycloalkeno [3,2-b] pyridines 失效
    取代的噻唑烷并[3,2-b]吡啶

    公开(公告)号：US4845225A

    公开(公告)日：1989-07-04

    申请号：US191676

    申请日：1988-05-09

    申请人： Charles F. Schwender ,  John H. Dodd

    发明人： Charles F. Schwender ,  John H. Dodd

    IPC分类号： C07D495/04

    CPC分类号： C07D495/04

    摘要： Novel substituted thiacycloalkeno [3,2-b] pyridines are described. These compounds are useful as calcium channel antagonists with cardiovascular, antiasthmatic and antibronchoconstrictor activity.

    摘要翻译： 描述了新的取代的硫杂环己烯并[3,2-b]吡啶。 这些化合物可用作具有心血管，抗哮喘和抗纤维支配作用的钙通道拮抗剂。

    Oxathiepino[6,5-b]dihydropyridines, and related compositions and methods
    8.
    发明授权
    Oxathiepino[6,5-b]dihydropyridines, and related compositions and methods 有权
    Oxathiepino [6,5-b]二氢吡啶类，以及相关组合物和方法

    公开(公告)号：US06476022B1

    公开(公告)日：2002-11-05

    申请号：US09603262

    申请日：2000-06-23

    申请人： John H. Dodd ,  James R. Henry ,  Kenneth C. Rupert ,  James L. Bullington ,  Daniel A. Hall

    发明人： John H. Dodd ,  James R. Henry ,  Kenneth C. Rupert ,  James L. Bullington ,  Daniel A. Hall

    IPC分类号： C07D49704

    CPC分类号： C07D497/04

    摘要： This invention provides novel oxathiepino[6,5-b]dihydropyridines. These compounds are useful as calcium channel antagonists with cardiovascular, antiasthmatic and antibronchoconstriction activity. Thus, this invention also provides pharmaceutical compositions, as well as methods, for preventing and treating disorders such as hypersensitivity, allergy, asthma, bronchospasm, dysmenorrhea, esophageal spasm, glaucoma, premature labor, urinary tract disorders, gastrointestinal motility disorders and cardiovascular disorders.

    摘要翻译： 本发明提供了新的氧硫杂环庚烯[6,5-b]二氢吡啶。 这些化合物可用作具有心血管，抗哮喘和抗纤维支配作用的钙通道拮抗剂。 因此，本发明还提供了用于预防和治疗诸如超敏反应，过敏，哮喘，支气管痉挛，痛经，食管痉挛，青光眼，早产，尿路障碍，胃肠蠕动障碍和心血管疾病等疾病的药物组合物以及方法。

    Dithiepino[6,5-b]pyridines, and related compositions and methods
    9.
    发明授权
    Dithiepino[6,5-b]pyridines, and related compositions and methods 有权
    Dithiepino [6,5-b]吡啶，以及相关组合物和方法

    公开(公告)号：US06291454B1

    公开(公告)日：2001-09-18

    申请号：US09580882

    申请日：2000-05-30

    申请人： James L. Bullington ,  John H. Dodd ,  Daniel A. Hall

    发明人： James L. Bullington ,  John H. Dodd ,  Daniel A. Hall

    IPC分类号： A61K3154

    CPC分类号： C07D495/04

    摘要： This invention provides novel dithiepino[6,5-b]pyridines of the following formulae. These compounds are useful as calcium channel antagonists with cardiovascular, antiasthinatic and antibronchoconstriction activity. Thus, this invention also provides pharmaceutical compositions, as well as methods, for preventing and treating disorders such as hypersensitivity, allergy, asthma, bronchospasm, dysmenorrhea, esophageal spasm, glaucoma, premature labor, urinary tract disorders, gastrointestinal motility disorders and cardiovascular disorders.

    摘要翻译： 本发明提供下列通式的新型二硫杂环庚烯[6,5-b]吡啶。这些化合物可用作具有心血管，抗衰老和抗纤维支配作用的钙通道拮抗剂。 因此，本发明还提供了用于预防和治疗诸如超敏反应，过敏，哮喘，支气管痉挛，痛经，食管痉挛，青光眼，早产，尿路障碍，胃肠蠕动障碍和心血管疾病等疾病的药物组合物以及方法。

    Benzosulfones and related compositions and methods
    10.
    发明授权
    Benzosulfones and related compositions and methods 有权
    苯并砜及相关组合物和方法

    公开(公告)号：US06410553B1

    公开(公告)日：2002-06-25

    申请号：US09751005

    申请日：2000-12-28

    申请人： John H. Dodd ,  Kenneth C. Rupert ,  James L. Bullington ,  Daniel A. Hall

    发明人： John H. Dodd ,  Kenneth C. Rupert ,  James L. Bullington ,  Daniel A. Hall

    IPC分类号： A61K3155

    CPC分类号： C07D495/04

    摘要： This invention provides novel benzosulfones of the following formulae: These compounds are useful as calcium channel antagonists with cardiovascular, antiasthmatic and antibronchoconstriction activity. Thus, this invention also provides pharmaceutical compositions, as well as methods, for preventing and treating disorders such as hypersensitivity, allergy, asthma, bronchospasm, dysmenorrhea, esophageal spasm, glaucoma, premature labor, urinary tract disorders, gastrointestinal motility disorders and cardiovascular disorders.

    摘要翻译： 本发明提供新的下式的苯并砜：这些化合物可用作具有心血管，止喘和抗纤维支配作用的钙通道拮抗剂。 因此，本发明还提供了用于预防和治疗诸如超敏反应，过敏，哮喘，支气管痉挛，痛经，食管痉挛，青光眼，早产，尿路障碍，胃肠蠕动障碍和心血管疾病等疾病的药物组合物以及方法。