Rifamycin analogs and uses thereof
    1.
    发明授权
    Rifamycin analogs and uses thereof 失效
    利妥霉素类似物及其用途

    公开(公告)号:US07488726B2

    公开(公告)日:2009-02-10

    申请号:US11591971

    申请日:2006-11-02

    CPC分类号: C07D498/18

    摘要: The present invention features rifamycin analogs that can be used as therapeutics for treating or preventing a variety of microbial infections. In one form, the analogs are acetylated at the 25-position, as is rifamycin. In another form, the analogs are deacetylated at the 25-position. In yet other forms, benzoxazinorifamycin, benzthiazinorifamycin, and benzdiazinorifamycin analogs are derivatized at various positions of the benzene ring, including 3′-hydroxy analogs, 5′-halo and/or alkoxy analogs, and various 4′- and/or 6′-substituents that incorporate a cyclic amine moiety.

    摘要翻译: 本发明的特征是利福霉素类似物可用作治疗或预防各种微生物感染的治疗剂。 在一种形式中,类似物在25位被乙酰化,就像利福霉素一样。 在另一种形式中,类似物在25位脱乙酰化。 在其他形式中,苯并恶嗪利霉素,苯并噻嗪可的霉素和苯并二氮霉素类似物在苯环的不同位置衍生化,包括3'-羟基类似物,5'-卤素和/或烷氧基类似物,以及各种4'-和/或6'- 引入环胺部分的取代基。