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1.发明申请Acylthiols and component thiol compositions as anti-hiv and anti-retroviral agents 有权酰基硫醇和组分硫醇组合物作为抗HIV和抗逆转录病毒剂公开(公告)号：US20050020831A1
公开(公告)日：2005-01-27
申请号：US10485165
申请日：2002-07-25
申请人： John Inman , Atul Goel , Ettore Appella , Jim Turpin , Marco Schito
发明人： John Inman , Atul Goel , Ettore Appella , Jim Turpin , Marco Schito
IPC分类号： C07C323/62 , C07C329/10 , C07C329/20 , C07C333/08 , C07C333/24 , C07D213/06 , C07D213/20 , C07
CPC分类号： C07D213/20 , C07C323/62 , C07C329/10 , C07C329/20 , C07C333/08 , C07C333/24 , C07D213/06
摘要： Certain thiol and acylthiol compounds inhibit retrovirus growth by attacking the highly conserved zinc finger regions of essential viral proteins. These compounds, compositions containing them, and methods of using them to treat retroviral infections such as HIV are described. These compounds are also useful for preparation of vaccines comprised of inactivated retroviruses such as HIV, prevention of the transmission of such retroviruses, and detection of retroviral proteins.
摘要翻译： 某些硫醇和酰基硫醇化合物通过攻击基本病毒蛋白的高度保守的锌指区域来抑制逆转录病毒的生长。 描述了这些化合物，含有它们的组合物和使用它们治疗逆转录病毒感染如HIV的方法。 这些化合物也可用于制备包括灭活的逆转录病毒如HIV的疫苗，预防这种逆转录病毒的传播，以及检测逆转录病毒蛋白质。
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2.发明授权Acylthiols and component thiol compositions as anti-HIV and anti-retroviral agents 有权酰基硫醇和组分硫醇组合物作为抗HIV和抗逆转录病毒剂公开(公告)号：US07528274B2
公开(公告)日：2009-05-05
申请号：US10485165
申请日：2002-07-25
申请人： John K. Inman , Atul Goel , Ettore Appella , Jim Turpin , Marco Schito
发明人： John K. Inman , Atul Goel , Ettore Appella , Jim Turpin , Marco Schito
IPC分类号： C07C327/16 , A61K31/21
CPC分类号： C07D213/20 , C07C323/62 , C07C329/10 , C07C329/20 , C07C333/08 , C07C333/24 , C07D213/06
摘要： Certain thiol and acylthiol compounds inhibit retrovirus growth by attacking the highly conserved zinc finger regions of essential viral proteins. These compounds, compositions containing them, and methods of using them to treat retroviral infections such as HIV are described. These compounds are also useful for preparation of vaccines comprised of inactivated retroviruses such as HIV, prevention of the transmission of such retroviruses, and detection of retroviral proteins.
摘要翻译： 某些硫醇和酰基硫醇化合物通过攻击基本病毒蛋白的高度保守的锌指区域来抑制逆转录病毒的生长。 描述了这些化合物，含有它们的组合物和使用它们治疗逆转录病毒感染如HIV的方法。 这些化合物也可用于制备包括灭活的逆转录病毒如HIV的疫苗，预防这种逆转录病毒的传播，以及检测逆转录病毒蛋白质。
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3.发明申请ACYTHIOLS AND COMPONENT THIOL COMPOSITIONS AS ANTI-HIV AND ANTI-RETROVIRAL AGENTS 有权ACYTHIOLS和组分THIOL组合物作为抗HIV和抗逆转录病毒公开(公告)号：US20090247473A1
公开(公告)日：2009-10-01
申请号：US12414321
申请日：2009-03-30
申请人： John K. Inman , Atul Goel , Ettore Appella , Jim Turpin , Marco Schito
发明人： John K. Inman , Atul Goel , Ettore Appella , Jim Turpin , Marco Schito
IPC分类号： A61K38/05 , C07K1/00 , C12N7/00 , G01N33/20 , C12N7/06 , A61K31/4425 , A61K31/708
CPC分类号： C07D213/20 , C07C323/62 , C07C329/10 , C07C329/20 , C07C333/08 , C07C333/24 , C07D213/06
摘要： Certain thiol and acylthiol compounds inhibit retrovirus growth by attacking the highly conserved zinc finger regions of essential viral proteins. These compounds, compositions containing them, and methods of using them to treat retroviral infections such as HIV are described. These compounds are also useful for preparation of vaccines comprised of inactivated retroviruses such as HIV, prevention of the transmission of such retroviruses, and detection of retroviral proteins.
摘要翻译： 某些硫醇和酰基硫醇化合物通过攻击基本病毒蛋白的高度保守的锌指区域来抑制逆转录病毒的生长。 描述了这些化合物，含有它们的组合物和使用它们治疗逆转录病毒感染如HIV的方法。 这些化合物也可用于制备包括灭活的逆转录病毒如HIV的疫苗，预防这种逆转录病毒的传播，以及检测逆转录病毒蛋白质。
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公开(公告)号：US5213970A
公开(公告)日：1993-05-25
申请号：US6814
申请日：1987-01-23
摘要： Disclosed herein is a novel antitumor factor, termed Human Monocyte Toxin, obtained by the precise activation of cells of monocyte/macrophage lineage. Monocytes are isolated in the absence of endotoxin by counterflow elutriation. HMT release can be triggered by exposure to low levels of 6-0-stearoyl muramyl dipeptide, lipopolysaccharide, phorbol myristate acetate or other known macrophage activating agents. Triggering results in the rapid release of HMT which requires transcription, translation, and intact secretory apparatus. The requirement for precise control of the triggering agent concentration is disclosed.The government may have certain rights in the present invention pursuant to NIH grant BRSG 5511.
摘要翻译： 本文公开了一种称为人单核细胞毒素的新型抗肿瘤因子，其通过单核细胞/巨噬细胞谱系的细胞的精确激活获得。 通过逆流淘析在不存在内毒素的情况下分离单核细胞。 HMT释放可以通过暴露于低水平的6-0硬脂酰胞壁酰二肽，脂多糖，佛波醇肉豆蔻酸乙酸酯或其它已知的巨噬细胞活化剂来触发。 触发导致需要转录，翻译和完整分泌装置的HMT的快速释放。 公开了对触发剂浓度的精确控制的要求。 基于使用常规或HPLC色谱法的分子筛分，无血清上清液中的HMT可以分解成两种不同的物种：100-120Kd的少量物种，称为α，主要形式β为60-70Kd。 通过色谱聚焦和HP离子交换LC进一步表征β-HMT，其表明中等酸性。 β-HMT在体外显示针对人和鼠细胞系的细胞毒性（细胞溶解和/或细胞抑制）活性。 靶点的β-HMT介导的裂解不涉及可检测的生成H 2 O 2或O 2 - ，也不能通过用TLCK预处理毒素而被阻断; 然而，当与靶细胞和β-HMT重合时，可逆蛋白酶抑制剂部分阻断裂解。
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