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    3.4-diaryl thiophenes and analogs thereof having use as antiinflammatory agents
    3.
    发明授权
    3.4-diaryl thiophenes and analogs thereof having use as antiinflammatory agents 失效
    具有用作抗炎剂的3,4-二芳基噻吩及其类似物

    公开(公告)号：US06492413B2

    公开(公告)日：2002-12-10

    申请号：US09528934

    申请日：2000-03-20

    申请人： John J. Talley ,  Stephen R Bertenshaw ,  Paul W Collins ,  Thomas D. Penning ,  David B. Reitz ,  Roland S Rogers

    发明人： John J. Talley ,  Stephen R Bertenshaw ,  Paul W Collins ,  Thomas D. Penning ,  David B. Reitz ,  Roland S Rogers

    IPC分类号： A61K314025

    CPC分类号： C07D307/38 ,  A61K31/341 ,  A61K31/365 ,  C07D307/58 ,  C07D333/16 ,  C07D333/18 ,  C07D333/28 ,  C07D333/38 ,  C07D409/04

    摘要： A class of 3,4-diaryl substituted thiophene, furan and pyrrole derivatives and analogs thereof, pharmaceutical compositions containing them and methods of using them to treat inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula I: wherein Y is selected from O, S and NR1; wherein R1 is selected from hydrido and lower alkyl; wherein X is one or two substituent selected from hydrido, halo, lower alkoxycarbonyl and carboxyl; wherein R2 and R3 are independently aryl or heteroaryl; and wherein R2 and R3 are optionally substituted at a substitutable position with one or more radicals selected from sulfamyl, alkylsulfonyl, halo, lower alkoxy and lower alkyl; or a pharmaceutically-acceptable salt thereof.

    摘要翻译： 一类3,4-二芳基取代的噻吩，呋喃和吡咯衍生物及其类似物，含有它们的药物组合物和使用它们治疗炎症和炎症相关疾病的方法。 特别感兴趣的化合物由式I定义：其中Y选自O，S和NR1; 其中R1选自氢和低级烷基; 其中X是一个或两个选自氢，卤素，低级烷氧基羰基和羧基的取代基; 其中R2和R3独立地是芳基或杂芳基; 并且其中R2和R3任选在可取代的位置被一个或多个选自磺酰胺基，烷基磺酰基，卤素，低级烷氧基和低级烷基的基团取代; 或其药学上可接受的盐。

    3,4-diaryl thiopenes and analogs thereof having use as antiinflammatory agents
    4.
    发明授权
    3,4-diaryl thiopenes and analogs thereof having use as antiinflammatory agents 失效
    具有用作抗炎剂的3,4-二芳基呋喃及其类似物

    公开(公告)号：US06599934B1

    公开(公告)日：2003-07-29

    申请号：US09711737

    申请日：2000-11-13

    申请人： John J. Talley ,  Stephen R Bertenshaw ,  Paul W Collins ,  Thomas D. Penning ,  David B. Reitz ,  Roland S Rogers

    发明人： John J. Talley ,  Stephen R Bertenshaw ,  Paul W Collins ,  Thomas D. Penning ,  David B. Reitz ,  Roland S Rogers

    IPC分类号： C07D30702

    CPC分类号： C07D307/38 ,  A61K31/341 ,  A61K31/365 ,  C07D307/58 ,  C07D333/16 ,  C07D333/18 ,  C07D333/28 ,  C07D333/38 ,  C07D409/04

    摘要： A class of 3,4-diaryl substituted thiophene, furan and pyrrole derivatives and analogs thereof, pharmaceutical compositions containing them and methods of using them to treat inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula I: wherein Y is selected from O, S and NR1; wherein R1 is selected from hydrido and lower alkyl; wherein X is one or two substituent selected from hydrido, halo, lower alkoxycarbonyl and carboxyl; wherein R2 and R3 are independently aryl or heteroaryl; and wherein R2 and R3 are optionally substituted at a substitutable position with one or more radicals selected from sulfamyl, alkylsulfonyl, halo, lower alkoxy and lower alkyl; or a pharmaceutically-acceptable salt thereof.

    摘要翻译： 一类3,4-二芳基取代的噻吩，呋喃和吡咯衍生物及其类似物，含有它们的药物组合物和使用它们治疗炎症和炎症相关疾病的方法。 特别感兴趣的化合物由式I定义：其中Y选自O，S和NR1; 其中R1选自氢和低级烷基; 其中X是一个或两个选自氢，卤素，低级烷氧基羰基和羧基的取代基; 其中R2和R3独立地是芳基或杂芳基; 并且其中R2和R3任选在可取代的位置被一个或多个选自磺酰胺基，烷基磺酰基，卤素，低级烷氧基和低级烷基的基团取代; 或其药学上可接受的盐。