公开(公告)号：US06187742B1

公开(公告)日：2001-02-13

申请号：US09274575

申请日：1999-03-23

申请人： John M. Wozney ,  Scott A. Rodeo ,  Jo A. Hannafin ,  Russell F. Warren

发明人： John M. Wozney ,  Scott A. Rodeo ,  Jo A. Hannafin ,  Russell F. Warren

IPC分类号： A61K3700

CPC分类号： C07K14/51 ,  A61K38/1875 ,  A61L27/227 ,  A61L27/24 ,  A61L27/54 ,  A61L27/56 ,  A61L2300/252 ,  A61L2300/414 ,  A61L2430/10

摘要： Methods and compositions are provided for the treatment of defects and disease involving the functional attachment of connective tissue, such as tendon or ligament, to bone. Preferred methods comprise administering a composition containing a bone morphogenetic protein and a suitable carrier. The method results in the regeneration of functional attachment between the connective tissue and bone, such that minimal fibrous or granulation tissue is formed at the interface between the regenerated bone and connective tissue. The method and composition are useful for augmenting tissue grafts in reconstructive surgery. The method and compositions result in closer apposition of bone to the connective tissue at earlier time points and increased strength of fixation at earlier time points.

摘要翻译： 提供了方法和组合物用于治疗涉及结缔组织（例如肌腱或韧带）到骨骼的功能性附着的缺陷和疾病。 优选的方法包括施用含有骨形态发生蛋白和合适载体的组合物。 该方法导致结缔组织与骨之间功能性附着的再生，使得在再生骨与结缔组织之间的界面处形成最小的纤维或肉芽组织。 该方法和组合物可用于在重建手术中增加组织移植物。 该方法和组合物在较早的时间点导致骨骼对结缔组织的更紧密的连接，并且在较早的时间点增加了固定的强度。