Methods for treatment of periodontal diseases and lesions using bone morphogenetic proteins
    3.
    发明授权
    Methods for treatment of periodontal diseases and lesions using bone morphogenetic proteins 失效
    使用骨形态发生蛋白治疗牙周病和病变的方法

    公开(公告)号:US06620406B1

    公开(公告)日:2003-09-16

    申请号:US08379813

    申请日:1995-01-27

    IPC分类号: A61K716

    CPC分类号: A61K38/1875 C07K14/51

    摘要: Methods and compositions are provided for the treatment of periodontal disease and bone lesions. Preferred methods comprise administering a composition containing one or more osteogenic and/or ligament-inducing bone morphogenetic protein and a suitable carrier. The method results in the regeneration of alveolar bone in both a vertical and horizontal direction, and can result in the regeneration of bone, cementum and ligamentous structure between said regenerated bone and the tooth root surface, such that minimal ankylosis and root resorption results. The method and composition are useful for the repair of supraalveolar periodontal lesions and defects, mandibular and maxillary class II and III furcations and interproximal defects, and augmentation of the alveolar ridge of these structures.

    摘要翻译: 提供方法和组合物用于治疗牙周病和骨损伤。 优选的方法包括施用含有一种或多种成骨和/或韧带诱导骨形态发生蛋白和合适载体的组合物。 该方法导致在垂直和水平方向上再生牙槽骨,并且可以导致所述再生骨与牙根表面之间的骨,牙骨质和韧带结构的再生,从而导致最小的强直和根吸收。 该方法和组合物可用于修复上述肺泡牙周病变和缺损,下颌和上颌第二类和第三类分支和间质缺损,并增加这些结构的牙槽嵴。

    Bone morphogenetic protein-11 (BMP-11) compositions
    4.
    发明授权
    Bone morphogenetic protein-11 (BMP-11) compositions 失效
    骨形态发生蛋白-11(BMP-11)组成

    公开(公告)号:US06437111B1

    公开(公告)日:2002-08-20

    申请号:US08919850

    申请日:1997-08-28

    IPC分类号: C07H2104

    摘要: Purified BMP-11 proteins and processes for producing them are disclosed. Recombinant DNA molecules encoding the BMP-11 proteins are also disclosed. The proteins may be useful in regulating follicle stimulating hormone, such as for contraception. In addition, the proteins may be useful for the induction of bone, cartilage and/or other connective tissue.

    摘要翻译: 公开了纯化的BMP-11蛋白质及其生产方法。 还公开了编码BMP-11蛋白的重组DNA分子。 蛋白质可用于调节促卵泡激素,例如用于避孕。 此外,蛋白质可用于诱导骨,软骨和/或其它结缔组织。

    Receptor proteins
    10.
    发明授权
    Receptor proteins 失效
    受体蛋白

    公开(公告)号:US06610513B2

    公开(公告)日:2003-08-26

    申请号:US09874628

    申请日:2001-06-05

    IPC分类号: C12P2106

    CPC分类号: C07K14/71 A61K38/00 C07K14/51

    摘要: Novel serine/threonine receptor proteins and BMP receptor proteins are disclosed, as well as DNA molecules encoding these proteins and methods of using the receptor proteins. Further disclosed are truncated BMP receptor proteins and molecules which act as ligands to these BMP receptor proteins.

    摘要翻译: 公开了新的丝氨酸/苏氨酸受体蛋白质和BMP受体蛋白质,以及编码这些蛋白质的DNA分子和使用受体蛋白质的方法。 进一步公开的是截短的BMP受体蛋白质和作为这些BMP受体蛋白质的配体的分子。