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1.发明申请公开(公告)号：US20120156763A1
公开(公告)日：2012-06-21
申请号：US13218287
申请日：2011-08-25
申请人： John P. Wikswo , Franz J. Baudenbacher , R. Robert Balcarcel , Theodore A. Bapty , David Cliffel , Sven Eklund , Owen McGuinness , Todd Monroe , Ales Prokop , Mark Andrew Stremler , Andreas Augustinus Werdich , Yang Yuansheng
发明人： John P. Wikswo , Franz J. Baudenbacher , R. Robert Balcarcel , Theodore A. Bapty , David Cliffel , Sven Eklund , Owen McGuinness , Todd Monroe , Ales Prokop , Mark Andrew Stremler , Andreas Augustinus Werdich , Yang Yuansheng
IPC分类号： C12M1/34
CPC分类号： G01N33/5005 , C12M41/32 , G01N33/5023 , G01N33/5038 , G01N33/5041 , G01N2015/1006 , Y10T436/115831
摘要： An apparatus and methods for using biological material to discriminate an agent. In one embodiment of the present invention, the method includes the steps of providing at least one cell, exposing at least one cell to an agent, measuring the response of the cell to the agent in terms of a physical quantity related to at least one of the cellular physiological activities of the cell, and identifying the agent from the measured response. The method further includes the step of quantifying the agent from the measured response.
摘要翻译： 用于使用生物材料来鉴别试剂的装置和方法。 在本发明的一个实施方案中，该方法包括以下步骤：提供至少一个细胞，将至少一个细胞暴露于药剂，根据与下列中的至少一个相关的物理量测量细胞对药剂的反应： 细胞的细胞生理活性，以及根据测定的反应鉴定药剂。 该方法还包括从所测量的响应量化试剂的步骤。
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2.发明申请Apparatus and methods for monitoring the status of a metabolically active cell 有权用于监测代谢活性细胞状态的装置和方法公开(公告)号：US20090305319A1
公开(公告)日：2009-12-10
申请号：US10213049
申请日：2002-08-06
申请人： Franz J. Baudenbacher , John P. Wikswo , R. Robert Balcarcel , David Cliffel , Sven Eklund , Jonathan Mark Gilligan , Owen McGuinness , Todd Monroe , Ales Prokop , Mark Andrew Stremler , Andreas Augustinus Werdich
发明人： Franz J. Baudenbacher , John P. Wikswo , R. Robert Balcarcel , David Cliffel , Sven Eklund , Jonathan Mark Gilligan , Owen McGuinness , Todd Monroe , Ales Prokop , Mark Andrew Stremler , Andreas Augustinus Werdich
CPC分类号： G01N33/5005 , C12M41/32 , G01N33/5023 , G01N33/5038 , G01N33/5041 , G01N2015/1006 , Y10T436/115831
摘要： An apparatus and methods for monitoring the status of a cell that consumes oxygen. In one embodiment of the present invention, the method includes the steps of confining the cell in a sensing volume, measuring dynamically intracellular or extracellular signaling of the cell, and determining the status of the cell from the measured intracellular or extracellular signaling of the cell.
摘要翻译： 用于监测消耗氧气的电池的状态的装置和方法。 在本发明的一个实施方案中，该方法包括以下步骤：将细胞限制在感测体积中，动态地测量细胞内的细胞内或细胞外信号传导，以及根据测定的细胞内或细胞外信号传导确定细胞的状态。
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3.发明授权Apparatus and methods for monitoring the status of a metabolically active cell 有权用于监测代谢活性细胞状态的装置和方法公开(公告)号：US07704745B2
公开(公告)日：2010-04-27
申请号：US10213049
申请日：2002-08-06
申请人： Franz Baudenbacher , John P. Wikswo , R. Robert Balcarcel , David Cliffel , Sven Eklund , Jonathan Mark Gilligan , Owen McGuinness , Todd Monroe , Ales Prokop , Mark Andrew Stremler , Andreas Augustinus Werdich
发明人： Franz Baudenbacher , John P. Wikswo , R. Robert Balcarcel , David Cliffel , Sven Eklund , Jonathan Mark Gilligan , Owen McGuinness , Todd Monroe , Ales Prokop , Mark Andrew Stremler , Andreas Augustinus Werdich
IPC分类号： G01N33/00
CPC分类号： G01N33/5005 , C12M41/32 , G01N33/5023 , G01N33/5038 , G01N33/5041 , G01N2015/1006 , Y10T436/115831
摘要： An apparatus and methods for monitoring the status of a cell that consumes oxygen. In one embodiment of the present invention, the method includes the steps of confining the cell in a sensing volume, measuring dynamically intracellular or extracellular signaling of the cell, and determining the status of the cell from the measured intracellular or extracellular signaling of the cell.
摘要翻译： 用于监测消耗氧气的电池的状态的装置和方法。 在本发明的一个实施方案中，该方法包括以下步骤：将细胞限制在感测体积中，动态地测量细胞内的细胞内或细胞外信号传导，以及根据测量的细胞内或细胞外信号传导确定细胞的状态。
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4.发明授权Device and methods for detecting the response of a plurality of cells to at least one analyte of interest 有权用于检测多个细胞对至少一种感兴趣分析物的响应的装置和方法公开(公告)号：US07713733B2
公开(公告)日：2010-05-11
申请号：US10483466
申请日：2002-08-06
申请人： David Cliffel , Franz J. Baudenbacher , John P. Wikswo , Sven Eklund , R. Robert Balcarcel , Jonathan M. Gilligan
发明人： David Cliffel , Franz J. Baudenbacher , John P. Wikswo , Sven Eklund , R. Robert Balcarcel , Jonathan M. Gilligan
CPC分类号： G01N33/5005 , C12M41/32 , G01N33/5023 , G01N33/5038 , G01N33/5041 , G01N2015/1006 , Y10T436/115831
摘要： An apparatus and methods for detecting at least one analyte of interest either produced or consumed by a plurality of cell. In one embodiment of the present invention, the method includes the steps of providing a housing defining a chamber, placing a plurality of cells in the chamber, and simultaneously detecting at least two analytes of interest either produced or consumed by the plurality of cells in the chamber.
摘要翻译： 一种用于检测由多个细胞产生或消耗的至少一种感兴趣分析物的装置和方法。 在本发明的一个实施例中，该方法包括以下步骤：提供限定腔室的壳体，将多个细胞放置在腔室中，同时检测至少两种感兴趣的分析物，所述分析物是由多个细胞产生或消耗的 房间。
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