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1.发明授权Process for encapsulating additives in resealed erythrocytes for disseminating chemicals via the circulatory system 失效在再密封的红细胞中包封添加剂以通过循环系统传播化学物质的方法
公开(公告)号：US4327710A
公开(公告)日：1982-05-04
申请号：US160753
申请日：1980-06-18
CPC分类号： A61D7/00 , A61K35/18 , A61K9/5068
摘要： An apparatus and a process for encapsulating additives in resealed erythrocytes from the blood of certain mammals. The invention provides a means of preparing material in substantial quantities, to be employed as vaccine which, when reinjected into these mammals, provides a systemic protection against blood-sucking insects or other parasites.
摘要翻译： 一种用于将某些哺乳动物的血液中的添加剂包封在再密封的红细胞中的装置和方法。 本发明提供了大量制备材料的方法，用作疫苗，当被重新注入这些哺乳动物时，其提供了针对吸血昆虫或其他寄生虫的全身保护。
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公开(公告)号：US4517080A
公开(公告)日：1985-05-14
申请号：US332906
申请日：1981-12-21
CPC分类号： A61K35/18 , A61D7/00 , A61K9/5068
摘要： An apparatus for encapsulating additives in resealed erythrocytes using dialysis is disclosed. A specimen holder, provided with vertical rotation means, is immersed in a dialyzing solution. Means are also provided for: agitation, cooling, heating, temperature control and measurement of the dialyzing solution.
摘要翻译： 公开了一种使用透析将添加剂包封在重新密封的红细胞中的装置。 将具有垂直旋转装置的样品架浸入透析溶液中。 还提供了用于：搅拌，冷却，加热，温度控制和透析溶液测量的手段。
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3.发明授权Method of providing systemic protection from bloodsucking insects and other parasites using encapsulated additives in resealed erythrocytes 失效使用包封的添加剂在重新密封的红细胞中提供全身保护免受吸血昆虫和其他寄生虫的方法
公开(公告)号：US4389209A
公开(公告)日：1983-06-21
申请号：US332905
申请日：1981-12-21
CPC分类号： A61K35/18
摘要： A process for encapsulating additives in resealed erythrocytes from the blood of certain mammals. The invention provides a method of preparing material in substantial quantities, to be employed as vaccine which, when reinjected into these mammals, provides a systemic protection against bloodsucking insects or other parasites.
摘要翻译： 一种从某些哺乳动物的血液中将添加剂包封在再密封的红细胞中的方法。 本发明提供了大量制备材料的方法，用作疫苗，当被重新注入这些哺乳动物时，其提供了防止吸血昆虫或其它寄生虫的全身防护。
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公开(公告)号：US5677176A
公开(公告)日：1997-10-14
申请号：US404372
申请日：1995-03-15
IPC分类号： A61K9/10 , A61K9/127 , A61K9/50 , A61K31/70 , A61K35/12 , A61K35/18 , A61K35/74 , A61K38/00 , A61K38/16 , A61K38/46 , A61K39/00 , A61K45/08 , A61P31/12 , A61P43/00 , C12N5/06 , G01N33/543 , G01N33/544 , G01N33/555 , G01N33/569 , C07K14/00
CPC分类号： B82Y5/00 , A61K35/18 , A61K38/168 , A61K9/1271 , A61K9/5068 , G01N33/5432 , G01N33/555 , G01N33/56988
摘要： This invention comprises animal derived cells, especially erythrocytes, which have been artificially modified (and referred to as engineered erythrocytes or RBCs) so as to incorporate in their plasma membranes an antigen, CD4 protein derived from lymphocytes) which will cause them to selectively seek out and fuse with other cells that are infected with a virus, especially the AIDS virus. These modified cells can be further altered so as to contain in their cytoplasm a cytotoxic agent which, after the cell has fused with a target cell, will result in the pooling of their respective cytoplasms and the death of both cells. Such modified cells can be used as a basis for an in vitro diagnostic assay involving cells derived from the blood of patients suspected of having AIDS.
摘要翻译： 本发明包括动物来源的细胞，特别是红细胞，其被人工修饰（并称为工程红细胞或RBC），以便在其质膜中掺入抗原，来源于淋巴细胞的CD4蛋白），这将导致它们选择性地寻找 并与感染病毒的其他细胞，特别是艾滋病病毒融合。 这些修饰的细胞可以进一步改变，以便在其细胞质中含有细胞毒剂，其在细胞与靶细胞融合后将导致其各自细胞质的汇集和两种细胞的死亡。 这种修饰的细胞可以用作涉及来自怀疑患有AIDS的患者的血液的细胞的体外诊断测定的基础。
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