Method of treating birds
    2.
    发明授权
    Method of treating birds 失效
    鸟类处理方法

    公开(公告)号:US5698193A

    公开(公告)日:1997-12-16

    申请号:US364484

    申请日:1994-12-27

    IPC分类号: A01K45/00 A61K38/19 A61K38/20

    CPC分类号: A01K45/007 A61K38/19

    摘要: A method of combatting microbial infections, including Escherichia coli and Salmonella infections, in immature birds by in ovo administration of an immune lymphokine (ILK) containing preparation in an amount effective to combat microbial infections in immature birds. A method of combatting microbial infections in immature birds by upregulating the production of endogenous Interleukin-8 (IL-8) in the bird. A method of combatting microbial infections in immature birds by in ovo administration of immune lymphokine (ILK).

    摘要翻译: 通过卵内施用含有有效防治未成熟鸟类微生物感染的量的免疫淋巴因子(ILK)制剂来防治未成熟鸟类的微生物感染(包括大肠杆菌和沙门氏菌感染)的方法。 通过上调鸟中内源性白细胞介素-8(IL-8)的产生来防治未成熟鸟类微生物感染的方法。 通过免疫淋巴细胞毒素(ILK)的免疫作用来防治未成熟鸟类中的微生物感染的方法。

    Probiotic for control of Salmonella
    5.
    发明授权
    Probiotic for control of Salmonella 失效
    益生菌用于控制沙门氏菌

    公开(公告)号:US5308615A

    公开(公告)日:1994-05-03

    申请号:US822505

    申请日:1992-01-17

    摘要: Salmonella colonization of fowl may be effectively controlled or inhibited using a defined composition of anaerobic bacteria (i.e., probiotic). the probiotic includes a first culture of substantially pure anaerobic bacteria effective for fermenting lactic acid to produce volatile organic acids including acetic, propionic and/or butyric acids. A second culture of at least one anaerobic bacteria effective for fermenting carbonhydrates to produce lactic acid is also employed in combination with the above-mentioned first cuture. Suitable organisms for use in this first culture include bacteria of the genera Veillonella, Megasphaera, and mixtures thereof. These first and second cultures are administered to the subject fowl in amounts effective for inhibiting Salmonella colonization thereof. In one embodiment, the above-mentioned probiotic may be combined with a conventional feed, providing a novel feed product which may be orally ingested by the fowl.

    摘要翻译: 可以使用规定的厌氧细菌组合物(即益生菌)有效地控制或抑制家禽的沙门氏菌定植。 益生菌包括有效用于发酵乳酸以产生包括乙酸,丙酸和/或丁酸的挥发性有机酸的基本纯净的厌氧细菌的第一培养物。 至少一种有效用于发酵碳水化合物以产生乳酸的至少一种厌氧细菌的第二种培养物也与上述第一种切割剂组合使用。 用于该第一培养物中的合适的生物体包括韦勒氏菌属,大戟科及其混合物的细菌。 将这些第一和第二培养物以有效抑制其沙门氏菌定植的量给予受试禽。 在一个实施方案中,上述益生菌可以与常规饲料组合,提供可以由家禽口服摄取的新型饲料产品。

    Monoclonal antibodies to ceftiofur
    8.
    发明授权
    Monoclonal antibodies to ceftiofur 失效
    头孢噻呋的单克隆抗体

    公开(公告)号:US5908781A

    公开(公告)日:1999-06-01

    申请号:US766250

    申请日:1996-12-10

    摘要: Hybridoma cell lines have been generated which produce and secrete monoclonal antibodies which selectively bind to the ceftiofur. These hybridomas may be obtained by using as an immunization agent or immunogen, desfuroyl ceftiofur which has been conjugated to an immunogenic carrier. Ceftiofur in biological samples may be detected and quantified by contacting the sample with the antibodies to form a ceftiofur/antibody immunocomplex when ceftiofur is present, which immunocomplex may then be detected. The monoclonal antibodies may also be incorporated into kits for the detection and quantification of ceftiofur.

    摘要翻译: 已经产生产生和分泌选择性结合头孢噻呋的单克隆抗体的杂交瘤细胞系。 这些杂交瘤可以通过使用已经与免疫原性载体缀合的免疫剂或免疫原,脱氧呋喃甲基头孢噻呋来获得。 生物样品中的头孢噻呋可以通过使样品与抗体接触以形成头孢噻呋/抗体免疫复合物,当头孢噻呋存在时可以检测和定量,然后可以检测该免疫复合物。 单克隆抗体也可以并入用于检测和定量头孢噻呋的试剂盒中。

    Probiotic for control of salmonella
    9.
    发明授权
    Probiotic for control of salmonella 失效
    益生菌用于控制沙门氏菌

    公开(公告)号:US5478557A

    公开(公告)日:1995-12-26

    申请号:US166779

    申请日:1993-12-13

    摘要: A defined probiotic or composition of anaerobic bacteria effective for controlling or inhibiting Salmonella colonization of fowl. The probiotic includes populations or cultures of 29 substantially biologically pure bacteria. In use, the probiotic is administered to the subject fowl in an amount effective for increasing resistance to Salmonella colonization thereof.The invention also relates to a novel method for isolating probiotics which are effective for controlling or inhibiting Salmonella colonization of domestic animals, from fecal droppings, cecal contents or large intestines of the adult animals. The droppings, cecal contents or large intestine are combined with a culture medium and incubated without dilution (i.e. batch culture) under anaerobic conditions. Following this preliminary incubation, the resultant culture is subjected to continuous flow conditions until a steady state is achieved, after which time the steady state culture may be recovered for use as a probiotic.

    摘要翻译: 定义的有益于控制或抑制家禽沙门氏菌定居的厌氧细菌的益生菌或组合物。 益生菌包括29种基本上生物纯的细菌的种群或培养物。 在使用中,将益生菌以有效增加对沙门氏杆菌定植的抗性的量施用于家禽。 本发明还涉及一种用于分离有益于控制或抑制家畜的沙门氏菌定殖的益生菌的新方法,来自成年动物的粪便粪便,盲肠内容物或大肠。 将粪便,盲肠内容物或大肠与培养基组合,并在无氧条件下进行稀释(即分批培养)孵育。 在该初步温育之后,将所得培养物进行连续流动条件直到达到稳定状态,此后可以恢复稳态培养物以用作益生菌。

    Probiotic for control of salmonella
    10.
    发明授权
    Probiotic for control of salmonella 失效
    益生菌用于控制沙门氏菌

    公开(公告)号:US5340577A

    公开(公告)日:1994-08-23

    申请号:US921173

    申请日:1992-07-29

    摘要: A defined probiotic or composition of anaerobic bacteria effective for controlling or inhibiting Salmonella colonization of fowl. The probiotic includes populations or cultures of substantially biologically pure bacteria, which bacteria include:(a) at least one Lactobacillus species;(b) one or both of:Lactococcus lactis, andCitrobacter freundii; and(c) at least one of:one or more Enterococcus species,one or more Bifidobacterium species,one or more Propionibacterium species, andone or more Escherichia species.In use, the probiotic is administered to the subject fowl in an amount effective for inhibiting Salmonella colonization thereof.The invention also relates to a novel method for isolating probiotics which are effective for controlling or inhibiting Salmonella colonization of fowl, from fecal droppings or cecal contents of adult fowl. The droppings or cecal contents are combined with a culture medium and incubated without dilution (i.e. batch culture) under anaerobic conditions. Following this preliminary incubation, the resultant culture is subjected to continuous flow conditions until a steady state is achieved, after which time the steady state culture may be recovered for use as a probiotic.

    摘要翻译: 定义的有益于控制或抑制家禽沙门氏菌定居的厌氧细菌的益生菌或组合物。 益生菌包括基本上生物纯的细菌的群体或培养物,该细菌包括:(a)至少一种乳杆菌属物种; (b)以下之一或两者:乳酸乳球菌和弗氏氟柠檬酸杆菌; 和(c)至少一种:一种或多种肠球菌属物种,一种或多种双歧杆菌属物种,一种或多种丙酸杆菌属物种和一种或多种埃希氏杆菌属物种。 在使用中,将益生菌以有效抑制其沙门氏菌定植的量给予受试禽。 本发明还涉及一种用于分离有益于控制或抑制家禽的沙门氏菌定殖的益生菌的新方法,来自粪便粪便或成年禽类的盲肠内容物。 将粪便或盲肠内容物与培养基组合,并在无氧条件下进行稀释(即分批培养)孵育。 在该初步温育之后,将所得培养物进行连续流动条件直到达到稳定状态,此后可以恢复稳态培养物以用作益生菌。