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公开(公告)号:US20120010262A1
公开(公告)日:2012-01-12
申请号:US13144031
申请日:2010-01-08
申请人: John Y.L. Chung , Yanfeng Zhang , Laura Artino , Jennifer Baxter , Aaron S. Cote , Donal Desmond , Jeremy Scott , Yekaterina Vaynshteyn
发明人: John Y.L. Chung , Yanfeng Zhang , Laura Artino , Jennifer Baxter , Aaron S. Cote , Donal Desmond , Jeremy Scott , Yekaterina Vaynshteyn
IPC分类号: A61K31/404 , A61P3/10 , C07D209/20
CPC分类号: C07D209/18 , C07B2200/13
摘要: The present invention relates to polymorphic forms of a compound of formula A: This compound is useful as a glucagon receptor antagonist and serves as a pharmaceutically active ingredient for the treatment of type 2 diabetes and related conditions, such as hyperglycemia, obesity, dyslipidemia, and the metabolic syndrome. Hydrates, hemihydrates, anhydrates and similar polymorphic forms are included.
摘要翻译: 本发明涉及式A化合物的多晶型物质:该化合物可用作胰高血糖素受体拮抗剂并用作用于治疗2型糖尿病和相关病症的药物活性成分,例如高血糖症,肥胖症,血脂异常和 代谢综合征。 包括水合物,半水合物,水合物和类似的多晶型物质。
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公开(公告)号:US08697740B2
公开(公告)日:2014-04-15
申请号:US13144031
申请日:2010-01-08
申请人: John Y. L. Chung , Yanfeng Zhang , Laura Artino , Jennifer Baxter , Aaron S. Cote , Yekaterina Vaynshteyn , Donal Desmond , Jeremy Scott
发明人: John Y. L. Chung , Yanfeng Zhang , Laura Artino , Jennifer Baxter , Aaron S. Cote , Yekaterina Vaynshteyn , Donal Desmond , Jeremy Scott
IPC分类号: A61K31/405 , C07D209/12
CPC分类号: C07D209/18 , C07B2200/13
摘要: The present invention relates to polymorphic forms of a compound of formula A: This compound is useful as a glucagon receptor antagonist and serves as a pharmaceutically active ingredient for the treatment of type 2 diabetes and related conditions, such as hyperglycemia, obesity, dyslipidemia, and the metabolic syndrome. Hydrates, hemihydrates, anhydrates and similar polymorphic forms are included.
摘要翻译: 本发明涉及式A化合物的多晶型物质:该化合物可用作胰高血糖素受体拮抗剂并用作用于治疗2型糖尿病和相关病症的药物活性成分,例如高血糖症,肥胖症,血脂异常和 代谢综合征。 包括水合物,半水合物,水合物和类似的多晶型物质。
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公开(公告)号:US20140206605A1
公开(公告)日:2014-07-24
申请号:US14239389
申请日:2012-08-16
申请人: Gregory L. Beutner , Robert M. Wenslow, JR. , Eric J. Choi , Clinton Scott Shultz , Jeremy Scott , Juan D. Arredondo , Laura Artino
发明人: Gregory L. Beutner , Robert M. Wenslow, JR. , Eric J. Choi , Clinton Scott Shultz , Jeremy Scott , Juan D. Arredondo , Laura Artino
IPC分类号: C07K5/12
CPC分类号: C07C35/04 , A61K38/00 , C07C67/14 , C07C69/013 , C07C69/12 , C07C269/04 , C07C271/34 , C07D403/12 , C07D498/16 , C07K5/0808 , C07K5/126
摘要: The present invention relates to different forms of a HCV inhibitory compound.
摘要翻译: 本发明涉及不同形式的HCV抑制化合物。
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公开(公告)号:US09242917B2
公开(公告)日:2016-01-26
申请号:US14239389
申请日:2012-08-16
申请人: Gregory L Beutner , Robert M Wenslow, Jr. , Eric J Choi , Clinton Scott Shultz , Jeremy Scott , Juan D Arredondo , Laura Artino
发明人: Gregory L Beutner , Robert M Wenslow, Jr. , Eric J Choi , Clinton Scott Shultz , Jeremy Scott , Juan D Arredondo , Laura Artino
IPC分类号: C07K5/08 , C07C35/04 , C07K5/083 , C07D403/12 , C07D498/16 , C07K5/12 , C07C67/14 , C07C69/013 , C07C69/12 , C07C269/04 , C07C271/34 , A61K38/00
CPC分类号: C07C35/04 , A61K38/00 , C07C67/14 , C07C69/013 , C07C69/12 , C07C269/04 , C07C271/34 , C07D403/12 , C07D498/16 , C07K5/0808 , C07K5/126
摘要: The present invention relates to different forms of a HCV inhibitory compound.
摘要翻译: 本发明涉及不同形式的HCV抑制化合物。
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公开(公告)号:US09238604B2
公开(公告)日:2016-01-19
申请号:US14239393
申请日:2012-08-16
申请人: Feng Xu , Guy Humphrey , Tao Pei , Zhiguo Jake Song , Tao Wang , Laura Artino
发明人: Feng Xu , Guy Humphrey , Tao Pei , Zhiguo Jake Song , Tao Wang , Laura Artino
IPC分类号: C07K5/08 , C07K5/10 , C07K5/12 , C07D401/12 , C07C35/04 , C07K5/083 , C07D403/12 , C07D498/16 , C07C67/14 , C07C69/013 , C07C69/12 , C07C269/04 , C07C271/34 , A61K38/00
CPC分类号: C07C35/04 , A61K38/00 , C07C67/14 , C07C69/013 , C07C69/12 , C07C269/04 , C07C271/34 , C07D403/12 , C07D498/16 , C07K5/0808 , C07K5/126
摘要: The present invention includes compounds useful as intermediates in the preparation of macrolactams, methods for preparing the intermediates, and methods for preparing macrolactams from the intermediates. One use of the methods and intermediates described herein is in the production of macrolactam compounds able to inhibit HCV NS3 protease activity. HCV NS3 inhibitory compounds have therapeutic and research applications.
摘要翻译: 本发明包括可用作制备中性物质的中间体的化合物,制备中间体的方法,以及从中间体制备大环内酯的方法。 本文描述的方法和中间体的一个用途是制备能够抑制HCV NS3蛋白酶活性的大环内酰胺化合物。 HCV NS3抑制化合物具有治疗和研究应用。
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公开(公告)号:US20140200343A1
公开(公告)日:2014-07-17
申请号:US14239393
申请日:2012-08-16
申请人: Feng Xu , Guy Humphrey , Tao Pei , Zhiguo Jake Song , Tao Wang , Laura Artino
发明人: Feng Xu , Guy Humphrey , Tao Pei , Zhiguo Jake Song , Tao Wang , Laura Artino
IPC分类号: C07D498/16 , C07D403/12
CPC分类号: C07C35/04 , A61K38/00 , C07C67/14 , C07C69/013 , C07C69/12 , C07C269/04 , C07C271/34 , C07D403/12 , C07D498/16 , C07K5/0808 , C07K5/126
摘要: The present invention includes compounds useful as intermediates in the preparation of macrolactams, methods for preparing the intermediates, and methods for preparing macrolactams from the intermediates. One use of the methods and intermediates described herein is in the production of macrolactam compounds able to inhibit HCV NS3 protease activity. HCV NS3 inhibitory compounds have therapeutic and research applications.
摘要翻译: 本发明包括可用作制备大新戊酰胺的中间体的化合物,制备中间体的方法和从中间体制备大环内酯的方法。 本文描述的方法和中间体的一个用途是制备能够抑制HCV NS3蛋白酶活性的大环内酰胺化合物。 HCV NS3抑制化合物具有治疗和研究应用。
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