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    MACROCYCLIC LACTONE COMPOUNDS AND METHODS FOR THEIR USE
    1.
    发明申请
    MACROCYCLIC LACTONE COMPOUNDS AND METHODS FOR THEIR USE 有权
    MACROCYCLIC LACTONE化合物及其使用方法

    公开(公告)号：US20120093891A1

    公开(公告)日：2012-04-19

    申请号：US13333526

    申请日：2011-12-21

    申请人： John Yan ,  Xiaoxia Zheng ,  Vinayak D. Bhat

    发明人： John Yan ,  Xiaoxia Zheng ,  Vinayak D. Bhat

    IPC分类号： A61K31/436 ,  A61K9/00 ,  A61F2/82 ,  A61M25/00 ,  A61P7/02 ,  A61P29/00 ,  A61P35/00 ,  A61P37/06 ,  A61M25/10 ,  C07D498/16 ,  A61F2/02 ,  B82Y5/00

    CPC分类号： A61K31/787 ,  A61L27/34 ,  A61L27/54 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/416 ,  A61K2300/00

    摘要： The present invention provides a pharmaceutical composition comprising a pharmaceutically acceptable excipient and a compound of the formula: wherein R1, R2, R3, R5, R6 and R8 are each independently a member selected from the group consisting of H, C1-6 alkyl and OH; R4, R7 and R9 are each independently selected from the group consisting of C1-6 alkoxy and OH; R10 is a member selected from the group consisting of H, —OH, —OP(O)Me2, —O—(CH2)n—OH and —O—(CH2)m—O—(CH2)o—CH3, wherein subscripts n and m are each independently from 2 to 8 and subscript o is from 1 to 6; each of L1 and L4 are independently selected from the group consisting of: each of L2 and L3 are independently selected from the group consisting of: and salts, hydrates, isomers, metabolites and prodrugs thereof.

    摘要翻译： 本发明提供包含药学上可接受的赋形剂和下式化合物的药物组合物：其中R 1，R 2，R 3，R 5，R 6和R 8各自独立地选自H，C 1-6烷基和OH ; R 4，R 7和R 9各自独立地选自C 1-6烷氧基和OH; R 10是选自H，-OH，-OP（O）Me 2，-O-（CH 2）n -OH和-O-（CH 2）m -O-（CH 2）o -CH 3的成员，其中 下标n和m各自独立地为2至8，下标o为1至6; L1和L4中的每一个独立地选自以下各项：L2和L3各自独立地选自：和其盐，水合物，异构体，代谢物和前药。

    MACROCYCLIC LACTONE COMPOUNDS AND METHODS FOR THEIR USE
    3.
    发明申请
    MACROCYCLIC LACTONE COMPOUNDS AND METHODS FOR THEIR USE 有权
    MACROCYCLIC LACTONE化合物及其使用方法

    公开(公告)号：US20080138375A1

    公开(公告)日：2008-06-12

    申请号：US11854312

    申请日：2007-09-12

    申请人： John Yan ,  Xiaoxia Zheng ,  Vinayak D. Bhat

    发明人： John Yan ,  Xiaoxia Zheng ,  Vinayak D. Bhat

    IPC分类号： A61F2/02 ,  A61K31/4353 ,  C07D221/06 ,  A61P43/00

    CPC分类号： A61K31/787 ,  A61L27/34 ,  A61L27/54 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/416 ,  A61K2300/00

    摘要： The present invention provides a pharmaceutical composition comprising a pharmaceutically acceptable excipient and a compound of the formula: wherein R1, R2, R3, R5, R6 and R8 are each independently a member selected from the group consisting of H, C1-6 alkyl and OH; R4, R7 and R9 are each independently selected from the group consisting of C1-6 alkoxy and OH; R10 is a member selected from the group consisting of H, —OH, —OP(O)Me2, —O—(CH2)n—OH and —O—(CH2)m—O—(CH2)o— CH3, wherein subscripts n and m are each independently from 2 to 8 and subscript o is from 1 to 6; each of L1 and L4 are independently selected from the group consisting of: each of L2 and L3 are independently selected from the group consisting of: salts, hydrates, isomers, metabolites and prodrugs thereof.

    摘要翻译： 本发明提供一种药物组合物，其包含药学上可接受的赋形剂和下式化合物：其中R 1，R 2，R 3， R 5，R 6和R 8各自独立地是选自H，C 1-6， 烷基和OH; R 4，R 7和R 9各自独立地选自C 1-6 - 烷氧基 和OH; R 10是选自H，-OH，-OP（O）Me 2，-O - （CH 2/2）， OH）和-O-（CH 2 CH 2）m -O - （CH 2 CH 2） 其中下标n和m各自独立地为2至8，下标o为1至6; L 1和L 4中的每一个独立地选自：L 2和L 3中的每一个， 独立地选自：其盐，水合物，异构体，代谢物和前药。

    MACROCYCLIC LACTONE COMPOUNDS AND METHODS FOR THEIR USE
    5.
    发明申请
    MACROCYCLIC LACTONE COMPOUNDS AND METHODS FOR THEIR USE 有权
    MACROCYCLIC LACTONE化合物及其使用方法

    公开(公告)号：US20120071500A1

    公开(公告)日：2012-03-22

    申请号：US13302588

    申请日：2011-11-22

    申请人： John Yan ,  Xiaoxia Zheng ,  Vinayak D. Bhat

    发明人： John Yan ,  Xiaoxia Zheng ,  Vinayak D. Bhat

    IPC分类号： A61K31/4741

    CPC分类号： A61K31/436 ,  A61K9/0004 ,  A61K31/439 ,  A61K31/4525 ,  A61K45/06

    摘要： The present invention provides a pharmaceutical composition comprising a pharmaceutically acceptable excipient and a compound of the formula: wherein R1, R2, R3, R5, R6, R8, M1, M2, M3, M4, M5, M6 and M7 are each independently a member selected from the group consisting of H, C1-6 alkyl, OH and C1-6 hydroxyalkyl; R4, R7 and R9 are each independently selected from the group consisting of C1-6 alkoxy and OH; R10 is a member selected from the group consisting of H, —OH, —OP(O)Me2, —O—(CH2)n—OH and —O—(CH2)m—O—(CH2)o—CH3, wherein subscripts n and m are each independently from 2 to 8 and subscript o is from 1 to 6; each of L1 and L4 are independently selected from the group consisting of: wherein each M8 is independently a member selected from the group consisting of C1-6 alkyl, OH and C1-6 hydroxyalkyl; each of L2 and L3 are independently selected from the group consisting of: and salts, hydrates, isomers, metabolites, N-oxides and prodrugs thereof.

    摘要翻译： 本发明提供包含药学上可接受的赋形剂和下式化合物的药物组合物：其中R1，R2，R3，R5，R6，R8，M1，M2，M3，M4，M5，M6和M7各自独立地为成员 选自H，C 1-6烷基，OH和C 1-6羟基烷基; R 4，R 7和R 9各自独立地选自C 1-6烷氧基和OH; R 10是选自H，-OH，-OP（O）Me 2，-O-（CH 2）n -OH和-O-（CH 2）m -O-（CH 2）o -CH 3的成员，其中 下标n和m各自独立地为2至8，下标o为1至6; L1和L4各自独立地选自：其中每个M8独立地是选自C 1-6烷基，OH和C 1-6羟基烷基的成员; L2和L3中的每一个独立地选自：其盐，水合物，异构体，代谢物，N-氧化物和前药。

    MACROCYCLIC LACTONE COMPOUNDS AND METHODS FOR THEIR USE
    7.
    发明申请
    MACROCYCLIC LACTONE COMPOUNDS AND METHODS FOR THEIR USE 有权
    MACROCYCLIC LACTONE化合物及其使用方法

    公开(公告)号：US20080234309A1

    公开(公告)日：2008-09-25

    申请号：US12046024

    申请日：2008-03-11

    申请人： John Yan ,  Xiaoxia Zheng ,  Vinayak D. Bhat

    发明人： John Yan ,  Xiaoxia Zheng ,  Vinayak D. Bhat

    IPC分类号： A61K31/4525 ,  A61P27/02 ,  C07D491/052

    CPC分类号： A61K31/436 ,  A61K9/0004 ,  A61K31/439 ,  A61K31/4525 ,  A61K45/06

    摘要： The present invention provides a pharmaceutical composition comprising a pharmaceutically acceptable excipient and a compound of the formula: wherein R1, R2, R3, R5, R6, R8, M1, M2, M3, M4, M5, M6 and M7 are each independently a member selected from the group consisting of H, C1-6 alkyl, OH and C1-6 hydroxyalkyl; R4, R7 and R9 are each independently selected from the group consisting of C1-6 alkoxy and OH; R10 is a member selected from the group consisting of H, —OH, —OP(O)Me2, —O—(CH2)n—OH and —O—(CH2)m—O—(CH2)o—CH3, wherein subscripts n and m are each independently from 2 to 8 and subscript o is from 1 to 6; each of L1 and L4 are independently selected from the group consisting of: wherein each M8 is independently a member selected from the group consisting of C1-6 alkyl, OH and C1-6 hydroxyalkyl; each of L2 and L3 are independently selected from the group consisting of: and salts, hydrates, isomers, metabolites, N-oxides and prodrugs thereof.

    摘要翻译： 本发明提供一种药物组合物，其包含药学上可接受的赋形剂和下式化合物：其中R 1，R 2，R 3， R 5，R 6，R 8，M 1，M 2， M 3，M 4，M 5，M 6和M 7均为 各自独立地是选自H，C 1-6烷基，OH和C 1-6 1-6羟基烷基的成员; R 4，R 7和R 9各自独立地选自C 1-6 - 烷氧基 和OH; R 10是选自H，-OH，-OP（O）Me 2，-O - （CH 2/2）， OH）和-O-（CH 2 CH 2）m -O - （CH 2 CH 2） 其中下标n和m各自独立地为2至8，下标o为1至6; L 1和L 4中的每一个独立地选自：其中每个M 8独立地是选自以下的成员： 的C 1-6烷基，OH和C 1-6烷基羟基烷基; L 2和L 3中的每一个独立地选自：其盐，水合物，异构体，代谢物，N-氧化物和前药。