公开(公告)号：US20110190763A1

公开(公告)日：2011-08-04

申请号：US12696239

申请日：2010-01-29

申请人： Jon F. Urban ,  Vinod Sharma ,  Mark T. Stewart

发明人： Jon F. Urban ,  Vinod Sharma ,  Mark T. Stewart

IPC分类号： A61B18/14

CPC分类号： A61N1/0575 ,  A61B5/042 ,  A61B5/6848 ,  A61B5/6852 ,  A61B2017/00053 ,  A61M25/0084 ,  A61M2025/0089 ,  A61M2025/0091

摘要： A system and associated method measure monophasic action potential signals for identifying a targeted tissue location and delivering a therapy to the targeted tissue location. The system includes a hollow needle having a sharpened distal tip, a first electrode at the distal tip and a fluid delivery lumen extending through the needle from a proximal needle end to an opening in the sharpened distal tip.

摘要翻译： 系统和相关联的方法测量用于识别目标组织位置并将治疗递送到目标组织位置的单相动作电位信号。 该系统包括具有锐化的远端尖端的中空针头，远侧末端处的第一电极和从近端针端延伸穿过尖锐远端的开口的流体输送腔。

公开(公告)号：US09144685B2

公开(公告)日：2015-09-29

申请号：US13357646

申请日：2012-01-25

申请人： Yong-Fu Xiao ,  Jeffrey M. Gillberg ,  Paul J. DeGroot ,  Eduardo N. Warman ,  Scott J. Brabec ,  John L. Sommer ,  Jon F. Urban ,  Lepeng Zeng

发明人： Yong-Fu Xiao ,  Jeffrey M. Gillberg ,  Paul J. DeGroot ,  Eduardo N. Warman ,  Scott J. Brabec ,  John L. Sommer ,  Jon F. Urban ,  Lepeng Zeng

IPC分类号： A61N1/00 ,  A61N1/365 ,  A61N1/362

CPC分类号： A61N1/365 ,  A61N1/3622 ,  A61N1/36585

摘要： An apparatus and method to discriminate cardiac events by sensing atrial and ventricular depolarizations having associated refractory periods thereafter. A fast ventricular rate is detected in response to the sensed ventricular depolarizations. Responsive to detecting the fast ventricular rate, at least one stimulus pulse is delivered to atrial tissue within the associated refractory period of the ventricle but outside of an associated refractory period of the stimulated atrial tissue. A ventricular response to the atrial tissue stimulus pulse is determined, and the cardiac event is discriminated based on the ventricular response to the atrial tissue stimulus pulse.

摘要翻译： 通过感应心房和心室去极化来区分心脏事件的装置和方法，其后具有相关联的不良期。 响应于感测到的心室去极化，检测到快速心室率。 响应于检测快速心室率，至少一个刺激脉冲被输送到心室的相关不应期内但在受刺激的心房组织的相关不应期内之外的心房组织。 确定对心房组织刺激脉冲的心室反应，并且基于对心房组织刺激脉冲的心室响应来区分心脏事件。

公开(公告)号：US20120232605A1

公开(公告)日：2012-09-13

申请号：US13357646

申请日：2012-01-25

申请人： Yong-Fu Xiao ,  Jeffrey M. Gillberg ,  Paul J. DeGroot ,  Eduardo N. Warman ,  Scott J. Brabec ,  John L. Sommer ,  Jon F. Urban ,  Lepeng Zeng

发明人： Yong-Fu Xiao ,  Jeffrey M. Gillberg ,  Paul J. DeGroot ,  Eduardo N. Warman ,  Scott J. Brabec ,  John L. Sommer ,  Jon F. Urban ,  Lepeng Zeng

IPC分类号： A61N1/365

CPC分类号： A61N1/365 ,  A61N1/3622 ,  A61N1/36585

摘要： An apparatus and method to discriminate cardiac events by sensing atrial and ventricular depolarizations having associated refractory periods thereafter. A fast ventricular rate is detected in response to the sensed ventricular depolarizations. Responsive to detecting the fast ventricular rate, at least one stimulus pulse is delivered to atrial tissue within the associated refractory period of the ventricle but outside of an associated refractory period of the stimulated atrial tissue. A ventricular response to the atrial tissue stimulus pulse is determined, and the cardiac event is discriminated based on the ventricular response to the atrial tissue stimulus pulse.

摘要翻译： 通过感应心房和心室去极化来区分心脏事件的装置和方法，其后具有相关联的不良期。 响应于感测到的心室去极化，检测到快速心室率。 响应于检测快速心室率，至少一个刺激脉冲被输送到心室的相关不应期内但在受刺激的心房组织的相关不应期内之外的心房组织。 确定对心房组织刺激脉冲的心室反应，并且基于对心房组织刺激脉冲的心室响应来区分心脏事件。

公开(公告)号：US08509893B2

公开(公告)日：2013-08-13

申请号：US12913354

申请日：2010-10-27

申请人： Yong-Fu Xiao ,  John L. Sommer ,  Scott J. Brabec ,  Lepeng Zeng ,  Jon F. Urban

发明人： Yong-Fu Xiao ,  John L. Sommer ,  Scott J. Brabec ,  Lepeng Zeng ,  Jon F. Urban

IPC分类号： A61N1/372

CPC分类号： A61N1/3622 ,  A61N1/36564 ,  A61N1/368

摘要： Various techniques for delivering atrial pacing and supraventricular stimulation to achieve a desired ventricular rate and/or cardiac output are described. One example method described includes delivering a pacing signal configured to cause an atrial depolarization to a heart of a patient, wherein the atrial depolarization results in an associated refractory period during the cardiac cycle, and delivering a signal to a supraventricular portion of the heart of the patient subsequent to the atrial refractory period and during a ventricular refractory period of the cardiac cycle.

摘要翻译： 描述用于递送心房起搏和室上性刺激以实现期望的心室率和/或心输出量的各种技术。 所描述的一个示例性方法包括递送起搏信号，所述起搏信号被配置成对患者的心脏进行心房去极化，其中所述心房去极化在心脏周期期间导致相关联的不应期，并将信号传递到心脏的心脏的室上部分 患者在心房不良期后和心动周期心室不应期。

公开(公告)号：US20120232606A1

公开(公告)日：2012-09-13

申请号：US13357659

申请日：2012-01-25

申请人： Yong-Fu Xiao ,  Jeffrey M. Gillberg ,  Paul J. DeGroot ,  Eduardo N. Warman ,  Scott J. Brabec ,  John L. Sommer ,  Jon F. Urban ,  Lepeng Zeng

发明人： Yong-Fu Xiao ,  Jeffrey M. Gillberg ,  Paul J. DeGroot ,  Eduardo N. Warman ,  Scott J. Brabec ,  John L. Sommer ,  Jon F. Urban ,  Lepeng Zeng

IPC分类号： A61N1/365

CPC分类号： A61N1/365 ,  A61N1/3622 ,  A61N1/36585

摘要： An apparatus and method to discriminate cardiac events by sensing atrial and ventricular depolarizations having associated refractory periods thereafter. A fast ventricular rate is detected in response to the sensed ventricular depolarizations. Responsive to detecting the fast ventricular rate, at least one stimulus pulse is delivered to atrial tissue within the associated refractory period of the ventricle but outside of an associated refractory period of the stimulated atrial tissue. A ventricular response to the atrial tissue stimulus pulse is determined, and the cardiac event is discriminated based on the ventricular response to the atrial tissue stimulus pulse.

公开(公告)号：US20120109237A1

公开(公告)日：2012-05-03

申请号：US12913354

申请日：2010-10-27

申请人： Yong-Fu Xiao ,  John L. Sommer ,  Scott J. Brabec ,  Lepeng Zeng ,  Jon F. Urban

发明人： Yong-Fu Xiao ,  John L. Sommer ,  Scott J. Brabec ,  Lepeng Zeng ,  Jon F. Urban

IPC分类号： A61N1/368 ,  A61N1/39 ,  A61N1/362

CPC分类号： A61N1/3622 ,  A61N1/36564 ,  A61N1/368

摘要： Various techniques for delivering atrial pacing and supraventricular stimulation to achieve a desired ventricular rate and/or cardiac output are described. One example method described includes delivering a pacing signal configured to cause an atrial depolarization to a heart of a patient, wherein the atrial depolarization results in an associated refractory period during the cardiac cycle, and delivering a signal to a supraventricular portion of the heart of the patient subsequent to the atrial refractory period and during a ventricular refractory period of the cardiac cycle.

摘要翻译： 描述用于递送心房起搏和室上性刺激以实现期望的心室率和/或心输出量的各种技术。 所描述的一个示例性方法包括递送起搏信号，所述起搏信号被配置成对患者的心脏进行心房去极化，其中所述心房去极化在心脏周期期间导致相关联的不应期，并将信号传递到心脏的心脏的室上部分 患者在心房不良期后和心动周期心室不应期。