公开(公告)号：US08639340B2

公开(公告)日：2014-01-28

申请号：US10635166

申请日：2003-08-06

申请人： John L. Sommer ,  Douglas S. Hine ,  Douglas N. Hess

发明人： John L. Sommer ,  Douglas S. Hine ,  Douglas N. Hess

IPC分类号： A61N1/375

CPC分类号： A61N1/3752

摘要： A connector sleeve includes a lumen adapted to receive a medical lead connector wherein a retention element engages a retention edge formed at a distal end of a connector element included on the lead connector. The connector sleeve further includes a contact element adapted to electrically engage the lead connector element within the lumen and an external conductive surface electrically coupled to the contact element and adapted for electrical engagement within the connector bore of an implantable medical device.

摘要翻译： 连接器套管包括适于接收医疗引线连接器的内腔，其中保持元件接合形成在包括在引线连接器上的连接器元件的远端处的保持边缘。 连接器套筒还包括适于电连接腔内的引线连接器元件的接触元件和电耦合到接触元件的外部导电表面，并且适于电连接在可植入医疗器械的连接器孔内。

公开(公告)号：US08509893B2

公开(公告)日：2013-08-13

申请号：US12913354

申请日：2010-10-27

申请人： Yong-Fu Xiao ,  John L. Sommer ,  Scott J. Brabec ,  Lepeng Zeng ,  Jon F. Urban

发明人： Yong-Fu Xiao ,  John L. Sommer ,  Scott J. Brabec ,  Lepeng Zeng ,  Jon F. Urban

IPC分类号： A61N1/372

CPC分类号： A61N1/3622 ,  A61N1/36564 ,  A61N1/368

摘要： Various techniques for delivering atrial pacing and supraventricular stimulation to achieve a desired ventricular rate and/or cardiac output are described. One example method described includes delivering a pacing signal configured to cause an atrial depolarization to a heart of a patient, wherein the atrial depolarization results in an associated refractory period during the cardiac cycle, and delivering a signal to a supraventricular portion of the heart of the patient subsequent to the atrial refractory period and during a ventricular refractory period of the cardiac cycle.

摘要翻译： 描述用于递送心房起搏和室上性刺激以实现期望的心室率和/或心输出量的各种技术。 所描述的一个示例性方法包括递送起搏信号，所述起搏信号被配置成对患者的心脏进行心房去极化，其中所述心房去极化在心脏周期期间导致相关联的不应期，并将信号传递到心脏的心脏的室上部分 患者在心房不良期后和心动周期心室不应期。

公开(公告)号：US20130006332A1

公开(公告)日：2013-01-03

申请号：US13616300

申请日：2012-09-14

申请人： John L. Sommer ,  David Wayne Bourn ,  Mark T. Marshall ,  Michael D. Eggen ,  Gabriela C. Miyazawa

发明人： John L. Sommer ,  David Wayne Bourn ,  Mark T. Marshall ,  Michael D. Eggen ,  Gabriela C. Miyazawa

IPC分类号： A61N1/37 ,  A61N1/36

CPC分类号： A61N1/36514 ,  A61N1/056 ,  A61N1/36114 ,  A61N1/36185 ,  A61N1/3684 ,  A61N1/3686 ,  A61N2001/0585

摘要： A medical system comprises a plurality of electrodes; at least one sensor configured to output at least one signal based on at least one physiological parameter of a patient; and a processor. The processor is configured to control delivery of stimulation to the patient using a plurality of electrode configurations. Each of the electrode configurations comprises at least one of the plurality of electrodes. For each of the electrode configurations, the processor is configured to determine a first response of target tissue to the stimulation based on the signals, and a second response of non-target tissue to the stimulation based on the signals. The processor is also configured to select at least one of the electrode configurations for delivery of stimulation to the patient based on the first and second responses for the electrode configurations. As examples, the target tissue may be a left ventricle or vagus nerve.

公开(公告)号：US08340783B2

公开(公告)日：2012-12-25

申请号：US12825647

申请日：2010-06-29

申请人： John L. Sommer ,  Kenneth C. Gardeski ,  Xiaonan Shen ,  Jon D. Schell

发明人： John L. Sommer ,  Kenneth C. Gardeski ,  Xiaonan Shen ,  Jon D. Schell

IPC分类号： A61N1/05

CPC分类号： A61N1/056 ,  A61N1/05 ,  A61N1/0534 ,  A61N1/0551 ,  A61N1/0558 ,  A61N1/086

摘要： An implantable lead including a lead body including an outer surface, a proximal end, a distal end, and at least one electrode; an electrically insulating member that extends axially over a first portion of the outer surface of the lead body between the proximal end and distal end, the electrically insulating member defining at least one aperture that exposes a first portion of the at least one electrode when in a first position over the lead body; and a reinforcement member formed at least partially of a different material than the insulating member and coupled to the insulating member, the reinforcement member extending axially over the outer surface of the lead body between the insulating member and proximal end. The reinforcement member may be configured to transfer at least one of a radial or axial force from a proximal portion of the reinforcement member to the insulating member, wherein the at least one of radial or axial force transferred to the insulating member is sufficient to move the insulating member over the outer surface of the lead body. In some examples, the lead may further include a deployable lobe member configured to anchor the reinforcement member and insulating member adjacent a tissue site within a patient.

摘要翻译： 一种可植入引线，包括：引线本体，其包括外表面，近端，远端和至少一个电极; 电绝缘构件，其在所述近端和远端之间轴向延伸到所述引线本体的外表面的第一部分上方，所述电绝缘构件限定在至少一个孔处暴露所述至少一个电极的第一部分， 领先身体的第一位; 至少部分地由与所述绝缘构件不同的材料形成并且与所述绝缘构件连接的加强构件，所述加强构件在所述绝缘构件和所述绝缘构件与所述绝缘构件之间的所述引线本体的外表面上轴向延伸。 加强构件可以构造成将径向或轴向力中的至少一个从加强构件的近侧部分传递到绝缘构件，其中传递到绝缘构件的径向或轴向力中的至少一个足以使 绝缘构件在引线体的外表面上。 在一些示例中，引线还可包括可展开的隆起部件，其构造成将加强部件和绝缘部件固定在患者体内的组织部位附近。

公开(公告)号：US20120232606A1

公开(公告)日：2012-09-13

申请号：US13357659

申请日：2012-01-25

申请人： Yong-Fu Xiao ,  Jeffrey M. Gillberg ,  Paul J. DeGroot ,  Eduardo N. Warman ,  Scott J. Brabec ,  John L. Sommer ,  Jon F. Urban ,  Lepeng Zeng

发明人： Yong-Fu Xiao ,  Jeffrey M. Gillberg ,  Paul J. DeGroot ,  Eduardo N. Warman ,  Scott J. Brabec ,  John L. Sommer ,  Jon F. Urban ,  Lepeng Zeng

IPC分类号： A61N1/365

CPC分类号： A61N1/365 ,  A61N1/3622 ,  A61N1/36585

摘要： An apparatus and method to discriminate cardiac events by sensing atrial and ventricular depolarizations having associated refractory periods thereafter. A fast ventricular rate is detected in response to the sensed ventricular depolarizations. Responsive to detecting the fast ventricular rate, at least one stimulus pulse is delivered to atrial tissue within the associated refractory period of the ventricle but outside of an associated refractory period of the stimulated atrial tissue. A ventricular response to the atrial tissue stimulus pulse is determined, and the cardiac event is discriminated based on the ventricular response to the atrial tissue stimulus pulse.

公开(公告)号：US08019420B2

公开(公告)日：2011-09-13

申请号：US10646545

申请日：2003-08-21

申请人： Douglas S. Hine ,  John L. Sommer ,  John Gurley

发明人： Douglas S. Hine ,  John L. Sommer ,  John Gurley

IPC分类号： A61N1/375

CPC分类号： H01R13/5224 ,  H01R31/06

摘要： A lead connector including a connector element array is fitted into a selected adaptor from a plurality of adaptors to electrically couple one or more elements of the connector element array, corresponding to one or more selected electrodes from an array of lead electrodes, to one or more contact zones of the selected adaptor in order to facilitate electrical connection with an implantable medical device.

摘要翻译： 将包括连接器元件阵列的引线连接器从多个适配器装配到所选择的适配器中，以将来自引线电极阵列的一个或多个所选电极的连接器元件阵列的一个或多个元件电耦合到一个或多个 接触区域，以便于与可植入医疗设备的电连接。

公开(公告)号：US07860580B2

公开(公告)日：2010-12-28

申请号：US11379849

申请日：2006-04-24

申请人： Jeffrey G. Falk ,  Douglas N. Hess ,  John L. Sommer

发明人： Jeffrey G. Falk ,  Douglas N. Hess ,  John L. Sommer

IPC分类号： A61N1/362

CPC分类号： A61N1/0573 ,  A61N2001/0585

摘要： A medical electrical lead includes a proximal insulation segment, a distal insulation segment, a conductor extending within the proximal and distal segments, and an electrode coupled to the conductor and disposed in proximity to a distal end of the distal insulation segment. A fixation element of the lead is coupled to a distal end of the proximal insulation segment and includes a wire wound in a helix, which extends distally from the proximal segment, over the distal insulation segment.

摘要翻译： 医疗电引线包括近端绝缘段，远侧绝缘段，在近端段和远侧区段内延伸的导体，以及耦合到导体并设置在远端绝缘区段的远端附近的电极。 引线的固定元件联接到近端绝缘节段的远端，并且包括缠绕在远端绝缘节段上的从近端段向远端延伸的螺旋线的线。

公开(公告)号：US20100114282A1

公开(公告)日：2010-05-06

申请号：US12683561

申请日：2010-01-07

申请人： Michael J. Ebert ,  John L. Sommer ,  Richard D. Ries ,  Jordan D. Honeck ,  Pedro A. Meregotte ,  Kenneth R. Brennen

发明人： Michael J. Ebert ,  John L. Sommer ,  Richard D. Ries ,  Jordan D. Honeck ,  Pedro A. Meregotte ,  Kenneth R. Brennen

IPC分类号： A61N1/05

CPC分类号： H01B3/306 ,  A61L31/10 ,  A61N1/056 ,  C08L79/08

摘要： An elongate medical electrical lead conductor includes a layer of hydrolytically stable polyimide formed thereover.

摘要翻译： 细长的医用电引线导体包括一层形成在其上的水解稳定的聚酰亚胺。

公开(公告)号：US20100114271A1

公开(公告)日：2010-05-06

申请号：US12262306

申请日：2008-10-31

申请人： John L. Sommer ,  Scott Brabec

发明人： John L. Sommer ,  Scott Brabec

IPC分类号： H01B3/44 ,  A61N1/04

CPC分类号： A61B5/0031 ,  A61B5/0006 ,  A61B2562/222 ,  A61N1/05 ,  A61N1/086

摘要： A lead for a medical device includes an elongate filar core member having an axis, which is operable for transmitting a lead signal. Furthermore, the lead includes an insulating layer disposed directly on the elongate filar core member and that extends along the axis. The lead also includes an electrically conductive layer disposed directly on the insulating layer and that extends along the axis.

摘要翻译： 用于医疗装置的引线包括具有轴的细长丝状芯构件，其可操作用于传送引导信号。 此外，引线包括绝缘层，其直接设置在细长丝状芯部件上并且沿轴线延伸。 引线还包括直接设置在绝缘层上并沿轴线延伸的导电层。

公开(公告)号：US20090054947A1

公开(公告)日：2009-02-26

申请号：US12195277

申请日：2008-08-20

申请人： David Wayne Bourn ,  John L. Sommer ,  Mark T. Marshall ,  Michael D. Eggen ,  Gabriela C. Miyazawa

发明人： David Wayne Bourn ,  John L. Sommer ,  Mark T. Marshall ,  Michael D. Eggen ,  Gabriela C. Miyazawa

IPC分类号： A61N1/362 ,  A61N1/05

CPC分类号： A61N1/368 ,  A61N1/0534 ,  A61N1/0551 ,  A61N1/056 ,  A61N1/36114 ,  A61N1/3684 ,  A61N2001/0585

摘要： A system includes an implantable electrical stimulation lead configured for intravenous introduction into a vessel proximate to a heart and an electrical stimulator. The lead comprises a lead body and at least three electrode segments. The electrical stimulator is coupled to the electrode segments and configures a first of the electrode segments as a first anode, a second of the electrode segments as a cathode, and a third of the electrode segments as a second anode, and delivers electrical stimulation to the heart via the cathode and first and second anodes. Additional techniques for delivering electrical stimulation include using multiple electrode segments as cathodes and electrically isolating other electrode segments. Other examples are directed to techniques for directing electrical therapy to a vagus nerve of a patient.

摘要翻译： 系统包括可植入的电刺激引线，其被配置为静脉内引入靠近心脏的血管和电刺激器。 引线包括引线体和至少三个电极段。 电刺激器耦合到电极段并且将第一电极段配置为第一阳极，将第二电极段作为阴极，将第三电极段作为第二阳极，并将电刺激传递到 心脏通过阴极和第一和第二阳极。 用于递送电刺激的附加技术包括使用多个电极段作为阴极并电隔离其它电极段。 其他实例涉及将电疗法引导到患者的迷走神经的技术。