公开(公告)号：US20050096740A1

公开(公告)日：2005-05-05

申请号：US10979838

申请日：2004-11-01

申请人： Jonathan Langberg ,  Michael Lesh ,  Erik van der Burg

发明人： Jonathan Langberg ,  Michael Lesh ,  Erik van der Burg

IPC分类号： A61F2/24

CPC分类号： A61F2/2451 ,  A61F2/2466

摘要： A mitral annuloplasty and left ventricle restriction device is designed to be transvenously advanced and deployed within the coronary sinus and in some embodiments other coronary veins The device places tension on adjacent structures, reducing the diameter and/or limiting expansion of the mitral annulus and/or limiting diastolic expansion of the left ventricle. These effects may be beneficial for patients with dilated cardiomyopathy.

摘要翻译： 二尖瓣成形术和左心室限制装置被设计成在冠状窦内被递送和展开，并且在一些实施例中被设计为其他冠状静脉。该装置将张力放置在相邻结构上，减小直径和/或限制二尖瓣环的扩张和/或 限制左心室的舒张期扩张。 这些影响可能对扩张型心肌病患者有益。

公开(公告)号：US20080262578A1

公开(公告)日：2008-10-23

申请号：US11969769

申请日：2008-01-04

申请人： Edwin Langberg ,  Julia Langberg ,  Jonathan Langberg

发明人： Edwin Langberg ,  Julia Langberg ,  Jonathan Langberg

IPC分类号： A61F7/00

CPC分类号： A61B18/1492 ,  A61B2018/00666 ,  A61B2018/00791

摘要： A tissue hyperthermia system and method improves temperature monitoring and control along an energy emitter such as an RF electrode. A two-phase heat transfer system includes a material within an enclosed vessel that is thermally coupled to the electrode. Energizing the electrode to an operating condition emits energy into tissue and heats at least to a threshold temperature wherein the material undergoes a phase transformation within the vessel between a liquid phase and a vapor phase. The phase change assists in cooling, monitoring, and control of emitter temperature. Algorithms estimate maximum temperature either at the emitter or in tissue adjacent the emitter based on monitored parameters at the vessel. Multivariate algorithms use simultaneous power and temperature readings to estimate actual regional temperature, including electrode or tissue hot-spot temperature. A multivariate algorithm is based in particular upon time-dependent aspects of a pulsed RF operating mode. The multi-variate algorithms benefit temperature monitoring and control either together with the two-phase heat transfer system or with other more conventional devices.

摘要翻译： 组织热疗系统和方法改善了诸如RF电极之类的能量发射器的温度监测和控制。 两相传热系统包括与密封容器内的热耦合到电极的材料。 将电极充电到操作条件将能量发射到组织中并加热至少至阈值温度，其中材料在液相和气相之间在容器内经历相变。 相变有助于冷却，监测和控制发射器温度。 算法在发射器或发射器附近的组织中估计最大温度，这取决于船上监测的参数。 多变量算法使用同时的功率和温度读数来估计实际区域温度，包括电极或组织热点温度。 多变量算法特别地基于脉冲RF操作模式的时间相关方面。 多变量算法可以与两相传热系统或其他更传统的设备一起有利于温度监测和控制。

公开(公告)号：US11114070B2

公开(公告)日：2021-09-07

申请号：US15516386

申请日：2015-10-06

申请人： Jonathan Langberg

发明人： Jonathan Langberg

IPC分类号： G10D3/046 ,  G10D1/08 ,  G10D3/00

摘要： An accessory for changing the timbre of a stringed instrument is provided, comprising a body having a vertical opening and a horizontal slot formed in the bottom surface from one edge into the vertical opening; an adjustment rod within the horizontal slot; and a dampener within the vertical opening associated with at least one string of the stringed instrument to which the accessory is attached. The adjustment rod has an upwardly angled inner end within the vertical opening in the body. The dampener comprises a dampener body; a soft fabric covering a top surface; and a bottom surface having a horizontal groove with a downwardly angled top surface matching the angle of the angle of the adjustment rod. Moving the adjustment rod inwardly moves the dampener upward and applies pressure to the string; moving the adjustment rod outwardly moves the dampener downward and reduces the pressure on the string.

公开(公告)号：US20120141587A1

公开(公告)日：2012-06-07

申请号：US13382771

申请日：2010-08-25

申请人： Dale Yoo ,  Sean Parick Whalen ,  Jonathan Langberg

发明人： Dale Yoo ,  Sean Parick Whalen ,  Jonathan Langberg

IPC分类号： A61K31/58 ,  A61K9/00 ,  A61P29/00

CPC分类号： A61K9/0024

摘要： Compositions, methods and kits for treatment or prevention of post operative organ or tissue inflammation are provided. The compositions contain an effective amount for local delivery, of an anti-inflammatory agent, alone or in combination with other pharmacologic agents, embedded within a polymeric matrix or gel. The polymeric matrix or gel may be a formed from natural or synthetic precursor components. The compositions are applied locally to an organ or tissue for the treatment or prevention of post inflammation resulting from surgical intervention.

摘要翻译： 提供了用于治疗或预防术后器官或组织炎症的组合物，方法和试剂盒。 组合物含有局部递送的有效量，抗炎剂，单独或与嵌入聚合物基质或凝胶内的其它药物组合。 聚合物基质或凝胶可以由天然或合成的前体组分形成。 将组合物局部施用于器官或组织用于治疗或预防由外科手术引起的炎症后炎症。

公开(公告)号：US20100069983A1

公开(公告)日：2010-03-18

申请号：US12436968

申请日：2009-05-07

申请人： James C. Peacock, III ,  Jonathan Langberg ,  Sean Patrick Whalen

发明人： James C. Peacock, III ,  Jonathan Langberg ,  Sean Patrick Whalen

IPC分类号： A61N1/05 ,  A61N1/362

CPC分类号： A61N1/057 ,  A61N1/0573

摘要： A cardiac stimulation system and method delivers a left ventricle stimulator from a right ventricle lead system in the right ventricle chamber, into a right side of an interventricular septum at a first location, and transmuscularly from the first location to a second location along the left side of the septum. The left ventricle stimulator is affixed at the second location for transmuscular stimulation of the left ventricle conduction system. A biventricular stimulation system further includes a right ventricle stimulator also delivered by the right ventricle lead system to the first location along the right side of the septum for right ventricular stimulation. An energy source is coupled to the transmuscular stimulation system, i.e., a pacemaker, and/or defibrillator, or to enhance contractility, and may be coupled directly or via “leadless” system(s). Various highly beneficial particular arrangements of stimulators and leads are further described.

摘要翻译： 心脏刺激系统和方法将右心室引导系统的右心室刺激器的左心室刺激器输送到第一位置处的室间隔的右侧，并且从左侧的第一位置到第二位置 的隔膜。 左心室刺激器固定在第二位置，用于左心室传导系统的多重刺激。 双心室刺激系统还包括右心室刺激器，其也由右心室引导系统递送到沿隔膜右侧的第一位置用于右心室刺激。 能量源耦合到多重刺激系统，即起搏器和/或去纤颤器，或增强收缩性，并且可以直接或经由“无引线”系统耦合。 进一步描述了刺激器和引线的各种非常有益的特定布置。