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4 条记录 (耗时 0.031 秒)

    6-(4-substituted-anilino)pyrimidine derivatives, method for preparation thereof and antiviral pharmaceutical composition comprising the same
    1.
    发明授权
    6-(4-substituted-anilino)pyrimidine derivatives, method for preparation thereof and antiviral pharmaceutical composition comprising the same 失效
    6-（4-取代 - 苯胺基）嘧啶衍生物，其制备方法和包含其的抗病毒药物组合物

    公开(公告)号：US07276501B2

    公开(公告)日：2007-10-02

    申请号：US10508306

    申请日：2003-03-25

    申请人： Jong-Woo Kim ,  Sang-Wook Lee ,  Geun-Hyung Lee ,  Jae-Jin Han ,  Sang-Jin Park ,  Eul-Yong Park ,  Joong-Chul Shin

    发明人： Jong-Woo Kim ,  Sang-Wook Lee ,  Geun-Hyung Lee ,  Jae-Jin Han ,  Sang-Jin Park ,  Eul-Yong Park ,  Joong-Chul Shin

    IPC分类号： A61K31/5377 ,  C07D413/14

    CPC分类号： C07D239/48 ,  C07D401/12

    摘要： The present invention relates to 6-(4-substituted-anilino)pyrimidine derivatives useful as an antiviral agent, and more particularly novel 6-(4-substituted-anilino)pyrimidine derivatives having an excellent inhibitory effect on replication of Hepatitis C virus; HCV), represented by the following formula I: in which R represents a C1-C4 straight or branched alkoxycarbonyl group, heterocycliccarbonyl group or carboxyalkyl group; and pharmaceutically acceptable salts thereof, a preparation method thereof, and an antiviral pharmaceutical composition comprising the compound as an effective ingredient. The 6-(4-substituted-anilino)pyrimidine derivatives according to the present invention have an excellent inhibitory effect on replication of Hepatitis C virus (HCV) and thus can be advantageously used as a therapeutic or prophylactic agent of hepatitis C.

    摘要翻译： 本发明涉及可用作抗病毒剂的6-（4-取代 - 苯胺基）嘧啶衍生物，更特别地涉及对丙型肝炎病毒复制具有优异抑制作用的更特别新颖的6-（4-取代苯胺基）嘧啶衍生物。 HCV），其由下式I表示：其中R表示C 1 -C 4直链或支链烷氧基羰基，杂环羰基或羧基烷基; 及其药学上可接受的盐，其制备方法和包含该化合物作为有效成分的抗病毒药物组合物。 根据本发明的6-（4-取代苯胺基）嘧啶衍生物对丙型肝炎病毒（HCV）的复制具有优异的抑制作用，因此可有利地用作丙型肝炎的治疗或预防剂。

    6-(4-substituted-anilino)pyrimidine derivates, method for preparation thereof and antiviral pharmaceutical composition comprising the same
    2.
    发明申请
    6-(4-substituted-anilino)pyrimidine derivates, method for preparation thereof and antiviral pharmaceutical composition comprising the same 失效
    6-（4-取代 - 苯胺基）嘧啶衍生物，其制备方法和包含其的抗病毒药物组合物

    公开(公告)号：US20050222150A1

    公开(公告)日：2005-10-06

    申请号：US10508306

    申请日：2003-03-25

    申请人： Jong-Woo Kim ,  Sang-Wook Lee ,  Geun-Hyung Lee ,  Jae-Jin Han ,  Sang-Jin Park ,  Eul-Yong Park ,  Joong-Chul Shin

    发明人： Jong-Woo Kim ,  Sang-Wook Lee ,  Geun-Hyung Lee ,  Jae-Jin Han ,  Sang-Jin Park ,  Eul-Yong Park ,  Joong-Chul Shin

    IPC分类号： C07D413/14 ,  A61K31/505 ,  A61K31/506 ,  A61P1/16 ,  A61P31/20 ,  C07D239/48 ,  C07D401/12 ,  A61K31/5377

    CPC分类号： C07D239/48 ,  C07D401/12

    摘要： The present invention relates to 6-(4-substituted-anilino)pyrimidine derivatives useful as an antiviral agent, and more particularly novel 6-(4-substituted-anilino)pyrimidine derivatives having an excellent inhibitory effect on replication of Hepatitis C virus; HCV), represented by the following formula I: in which R represents a C1-C4 straight or branched alkoxycarbonyl group, heterocycliccarbonyl group or carboxyalkyl group; and pharmaceutically acceptable salts thereof, a preparation method thereof, and an antiviral pharmaceutical composition comprising the compound as an effective ingredient. The 6-(4-substituted-anilino)pyrimidine derivatives according to the present invention have an excellent inhibitory effect on replication of Hepatitis C virus (HCV) and thus can be advantageously used as a therapeutic or prophylactic agent of hepatitis C.

    摘要翻译： 本发明涉及可用作抗病毒剂的6-（4-取代 - 苯胺基）嘧啶衍生物，更特别地涉及对丙型肝炎病毒复制具有优异抑制作用的更特别新颖的6-（4-取代苯胺基）嘧啶衍生物。 HCV），其由下式I表示：其中R表示C 1 -C 4直链或支链烷氧基羰基，杂环羰基或羧基烷基; 及其药学上可接受的盐，其制备方法和包含该化合物作为有效成分的抗病毒药物组合物。 根据本发明的6-（4-取代苯胺基）嘧啶衍生物对丙型肝炎病毒（HCV）的复制具有优异的抑制作用，因此可有利地用作丙型肝炎的治疗或预防剂。

    6-Methylpyridine derivatives, method for preparing thereof and antiviral pharmaceutical composition comprising the same
    3.
    发明授权
    6-Methylpyridine derivatives, method for preparing thereof and antiviral pharmaceutical composition comprising the same 失效
    6-甲基吡啶衍生物，其制备方法和包含其的抗病毒药物组合物

    公开(公告)号：US07244731B2

    公开(公告)日：2007-07-17

    申请号：US10528461

    申请日：2003-10-02

    申请人： Jong-Woo Kim ,  Sang-Wook Lee ,  Geun-Hyung Lee ,  Jae-Jin Han ,  Sang-Jin Park ,  Eul-Yong Park ,  Joong-Chul Shin

    发明人： Jong-Woo Kim ,  Sang-Wook Lee ,  Geun-Hyung Lee ,  Jae-Jin Han ,  Sang-Jin Park ,  Eul-Yong Park ,  Joong-Chul Shin

    IPC分类号： A61K31/5377 ,  C07D413/02

    CPC分类号： C07D213/80

    摘要： The present invention relates to 6-methylpyridine derivatives useful as an antiviral agent. More particularly, the present invention relates to novel 6-methylpyridine derivatives having an excellent inhibitory effect on replication of Hepatitis C virus (HCV), or pharmaceutically acceptable salts thereof, to a method for preparing thereof, and to an antiviral pharmaceutical composition comprising the compound as an active ingredient. The 6-methylpyridine derivatives of the present invention have an excellent inhibitory effect on replication of hepatitis C virus and thus can be advantageously used as a therapeutic or prophylactic agent of hepatitis C

    摘要翻译： 本发明涉及可用作抗病毒剂的6-甲基吡啶衍生物。 更具体地说，本发明涉及对丙型肝炎病毒（HCV）的复制或其药学上可接受的盐对其制备方法具有优异抑制作用的新型6-甲基吡啶衍生物，以及含有该化合物的抗病毒药物组合物 作为活性成分。 本发明的6-甲基吡啶衍生物对丙型肝炎病毒的复制具有优异的抑制作用，因此可有利地用作丙型肝炎的治疗或预防药物