公开(公告)号：US20120244614A1

公开(公告)日：2012-09-27

申请号：US13513743

申请日：2010-12-08

Applicant: Jae-Jin Han

Inventor： Jae-Jin Han

IPC: C12N5/07

CPC classification number: C12N5/0602 ,  C12N5/0018 ,  C12N2500/76

Abstract: Provided is a method for culturing cells, which prevents the possibility of mycoplasma contamination by culturing the cells using biomass extract obtained by culturing a strain with amphidinol productivity, preferably a strain such as Amphidinium klebsii, Amphididinium carterae, and the like belonging to Dinoflagellates, or using a fraction obtained from the extract; and a method for removing mycoplasma contamination of the cells by culturing the cells contaminated by mycoplasma using the amphidinol derivatives. In addition, provided is a method for removing mycoplasma contamination of the cells, including a combination of single cell-isolating enzyme solution treatment and cell aggregate removal.

Abstract translation: 本发明提供一种培养细胞的方法，其通过利用通过培养具有阿奇霉素生产力的菌株获得的生物质提取物优选培养细胞来防止支原体污染的可能性，优选菌株如属于鞭毛藻的as螨属（Amphidinium klebsii），镰孢菌纲（Amphididinium carterae）等，或 使用从提取物获得的级分; 以及通过使用二甲啶醇衍生物培养受支原体污染的细胞来去除细胞的支原体污染的方法。 此外，提供了除去细胞的支原体污染的方法，包括单细胞分离酶溶液处理和细胞聚集体去除的组合。

公开(公告)号：US20060288139A1

公开(公告)日：2006-12-21

申请号：US11439945

申请日：2006-05-25

Applicant: Jae-soon Lee ,  Jae-jin Han ,  Joon Lee ,  Hae-jin Hwang

Inventor： Jae-soon Lee ,  Jae-jin Han ,  Joon Lee ,  Hae-jin Hwang

IPC: G06F13/38

CPC classification number: G06F1/16 ,  G06F1/1601 ,  G06F1/181 ,  H01R9/032 ,  H01R27/00

Abstract: A computer system includes a computer main body provided with a plurality of main body input-output ports; a monitor main body to display an image; a console stand having a console casing with an accommodating space inside and supporting the monitor main body, console input-output ports outside the console casing and connectable to an external device, an integrated port outside the console casing, and a control module controlling an interface between the integrated port and the console input-output port; and a main body/console cable having main body connectors respectively connected to the main body input-output ports, a console connector connected to the integrated port, an integrated cable electrically connecting the plurality of main body connectors and the console connector.

Abstract translation: 计算机系统包括具有多个主体输入输出端口的计算机主体; 显示器主体，用于显示图像; 具有控制台壳体的控制台，其具有内部的容纳空间并且支撑监视器主体，控制台壳体外部的控制台输入输出端口并且可连接到外部设备，控制台壳体外部的集成端口以及控制接口的控制模块 集成端口和控制台输入输出端口之间; 主体/控制台电缆，其主体连接器分别连接到主体输入输出端口，连接到集成端口的控制台连接器，电连接多个主体连接器和控制台连接器的集成电缆。

公开(公告)号：US20050222150A1

公开(公告)日：2005-10-06

申请号：US10508306

申请日：2003-03-25

Applicant: Jong-Woo Kim ,  Sang-Wook Lee ,  Geun-Hyung Lee ,  Jae-Jin Han ,  Sang-Jin Park ,  Eul-Yong Park ,  Joong-Chul Shin

Inventor： Jong-Woo Kim ,  Sang-Wook Lee ,  Geun-Hyung Lee ,  Jae-Jin Han ,  Sang-Jin Park ,  Eul-Yong Park ,  Joong-Chul Shin

IPC: C07D413/14 ,  A61K31/505 ,  A61K31/506 ,  A61P1/16 ,  A61P31/20 ,  C07D239/48 ,  C07D401/12 ,  A61K31/5377

CPC classification number: C07D239/48 ,  C07D401/12

Abstract: The present invention relates to 6-(4-substituted-anilino)pyrimidine derivatives useful as an antiviral agent, and more particularly novel 6-(4-substituted-anilino)pyrimidine derivatives having an excellent inhibitory effect on replication of Hepatitis C virus; HCV), represented by the following formula I: in which R represents a C1-C4 straight or branched alkoxycarbonyl group, heterocycliccarbonyl group or carboxyalkyl group; and pharmaceutically acceptable salts thereof, a preparation method thereof, and an antiviral pharmaceutical composition comprising the compound as an effective ingredient. The 6-(4-substituted-anilino)pyrimidine derivatives according to the present invention have an excellent inhibitory effect on replication of Hepatitis C virus (HCV) and thus can be advantageously used as a therapeutic or prophylactic agent of hepatitis C.

Abstract translation: 本发明涉及可用作抗病毒剂的6-（4-取代 - 苯胺基）嘧啶衍生物，更特别地涉及对丙型肝炎病毒复制具有优异抑制作用的更特别新颖的6-（4-取代苯胺基）嘧啶衍生物。 HCV），其由下式I表示：其中R表示C 1 -C 4直链或支链烷氧基羰基，杂环羰基或羧基烷基; 及其药学上可接受的盐，其制备方法和包含该化合物作为有效成分的抗病毒药物组合物。 根据本发明的6-（4-取代苯胺基）嘧啶衍生物对丙型肝炎病毒（HCV）的复制具有优异的抑制作用，因此可有利地用作丙型肝炎的治疗或预防剂。

公开(公告)号：US08815565B2

公开(公告)日：2014-08-26

申请号：US13513743

申请日：2010-11-24

Applicant: Jae-Jin Han

Inventor： Jae-Jin Han

IPC: C12N1/00

CPC classification number: C12N5/0602 ,  C12N5/0018 ,  C12N2500/76

Abstract: Provided is a method for culturing cells, which prevents the possibility of mycoplasma contamination by culturing the cells using biomass extract obtained by culturing a strain with amphidinol productivity, preferably a strain such as Amphidinium klebsii, Amphididinium carterae, and the like belonging to Dinoflagellates, or using a fraction obtained from the extract; and a method for removing mycoplasma contamination of the cells by culturing the cells contaminated by mycoplasma using the amphidinol derivatives. In addition, provided is a method for removing mycoplasma contamination of the cells, including a combination of single cell-isolating enzyme solution treatment and cell aggregate removal.

Abstract translation: 本发明提供一种培养细胞的方法，其通过利用通过培养具有阿奇霉素生产力的菌株获得的生物质提取物优选培养细胞来防止支原体污染的可能性，优选菌株如属于鞭毛藻的as螨属（Amphidinium klebsii），镰孢菌纲（Amphididinium carterae）等，或 使用从提取物获得的级分; 以及通过使用二甲啶醇衍生物培养受支原体污染的细胞来去除细胞的支原体污染的方法。 此外，提供了除去细胞的支原体污染的方法，包括单细胞分离酶溶液处理和细胞聚集体去除的组合。

公开(公告)号：US08809034B2

公开(公告)日：2014-08-19

申请号：US14090768

申请日：2013-11-26

Applicant: Jae-Jin Han

Inventor： Jae-Jin Han

IPC: C12N1/00

CPC classification number: C12N5/0602 ,  C12N5/0018 ,  C12N2500/76

Abstract: Provided is a method for culturing cells, which prevents the possibility of mycoplasma contamination by culturing the cells using biomass extract obtained by culturing a strain with amphidinol productivity, preferably a strain such as Amphidinium klebsii, Amphididinium carterae, and the like belonging to Dinoflagellates, or using a fraction obtained from the extract; and a method for removing mycoplasma contamination of the cells by culturing the cells contaminated by mycoplasma using the amphidinol derivatives. In addition, provided is a method for removing mycoplasma contamination of the cells, including a combination of single cell-isolating enzyme solution treatment and cell aggregate removal.

公开(公告)号：US07276501B2

公开(公告)日：2007-10-02

申请号：US10508306

申请日：2003-03-25

Applicant: Jong-Woo Kim ,  Sang-Wook Lee ,  Geun-Hyung Lee ,  Jae-Jin Han ,  Sang-Jin Park ,  Eul-Yong Park ,  Joong-Chul Shin

Inventor： Jong-Woo Kim ,  Sang-Wook Lee ,  Geun-Hyung Lee ,  Jae-Jin Han ,  Sang-Jin Park ,  Eul-Yong Park ,  Joong-Chul Shin

IPC: A61K31/5377 ,  C07D413/14

CPC classification number: C07D239/48 ,  C07D401/12

Abstract: The present invention relates to 6-(4-substituted-anilino)pyrimidine derivatives useful as an antiviral agent, and more particularly novel 6-(4-substituted-anilino)pyrimidine derivatives having an excellent inhibitory effect on replication of Hepatitis C virus; HCV), represented by the following formula I: in which R represents a C1-C4 straight or branched alkoxycarbonyl group, heterocycliccarbonyl group or carboxyalkyl group; and pharmaceutically acceptable salts thereof, a preparation method thereof, and an antiviral pharmaceutical composition comprising the compound as an effective ingredient. The 6-(4-substituted-anilino)pyrimidine derivatives according to the present invention have an excellent inhibitory effect on replication of Hepatitis C virus (HCV) and thus can be advantageously used as a therapeutic or prophylactic agent of hepatitis C.

Abstract translation: 本发明涉及可用作抗病毒剂的6-（4-取代 - 苯胺基）嘧啶衍生物，更特别地涉及对丙型肝炎病毒复制具有优异抑制作用的更特别新颖的6-（4-取代苯胺基）嘧啶衍生物。 HCV），其由下式I表示：其中R表示C 1 -C 4直链或支链烷氧基羰基，杂环羰基或羧基烷基; 及其药学上可接受的盐，其制备方法和包含该化合物作为有效成分的抗病毒药物组合物。 根据本发明的6-（4-取代苯胺基）嘧啶衍生物对丙型肝炎病毒（HCV）的复制具有优异的抑制作用，因此可有利地用作丙型肝炎的治疗或预防剂。

公开(公告)号：US06306860B1

公开(公告)日：2001-10-23

申请号：US09674844

申请日：2000-11-07

Applicant: Sung Joon Yoon ,  Sang Wook Lee ,  Hyeong Su Sim ,  Yong Kyun Park ,  Wang Yong Yang ,  Jong Woo Kim ,  Jae Jin Han ,  Je In Yoon ,  Sang Jin Park ,  Hee Jeoung Park ,  Dong Hyuk Sin ,  Hwan Bong Chang

Inventor： Sung Joon Yoon ,  Sang Wook Lee ,  Hyeong Su Sim ,  Yong Kyun Park ,  Wang Yong Yang ,  Jong Woo Kim ,  Jae Jin Han ,  Je In Yoon ,  Sang Jin Park ,  Hee Jeoung Park ,  Dong Hyuk Sin ,  Hwan Bong Chang

IPC: C07D40114

CPC classification number: C07D213/82 ,  C07D401/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14

Abstract: Anti-viral agents of formula (1) have been identified. Their preparation method is described. These 2,5-pyridinedicarboxylic acid derivatives or their pharmaceutically acceptable salts are useful in countering the proliferation of viruses such as hepatitis B virus and human immunodeficiency virus.

Abstract translation: 已经鉴定了式（1）的抗病毒剂。 描述了它们的制备方法。 这些2,5-吡啶二羧酸衍生物或其药学上可接受的盐可用于对抗乙型肝炎病毒和人类免疫缺陷病毒等病毒的增殖。

公开(公告)号：US08871749B2

公开(公告)日：2014-10-28

申请号：US13643803

申请日：2011-04-25

Applicant: Jae-Jin Han

Inventor： Jae-Jin Han

IPC: A61K31/60 ,  A61K31/235 ,  A61K31/618 ,  A61L27/50 ,  C07C69/84 ,  A61C8/02 ,  C07C65/03

CPC classification number: A61C8/0006 ,  A61L27/50 ,  A61L2430/02 ,  A61L2430/12 ,  C07C65/03 ,  C07C69/84

Abstract: Provided is a bone-transplant or bone-filling composition, which comprises a dihydroxybenzoic acid derivative which has been newly demonstrated to increase the activity of osteoblasts and so induce bone formation.

Abstract translation: 提供了一种骨移植或骨填充组合物，其包含已被新证实增加成骨细胞活性并因此诱导骨形成的二羟基苯甲酸衍生物。

公开(公告)号：US07244731B2

公开(公告)日：2007-07-17

申请号：US10528461

申请日：2003-10-02

Applicant: Jong-Woo Kim ,  Sang-Wook Lee ,  Geun-Hyung Lee ,  Jae-Jin Han ,  Sang-Jin Park ,  Eul-Yong Park ,  Joong-Chul Shin

Inventor： Jong-Woo Kim ,  Sang-Wook Lee ,  Geun-Hyung Lee ,  Jae-Jin Han ,  Sang-Jin Park ,  Eul-Yong Park ,  Joong-Chul Shin

IPC: A61K31/5377 ,  C07D413/02

CPC classification number: C07D213/80

Abstract: The present invention relates to 6-methylpyridine derivatives useful as an antiviral agent. More particularly, the present invention relates to novel 6-methylpyridine derivatives having an excellent inhibitory effect on replication of Hepatitis C virus (HCV), or pharmaceutically acceptable salts thereof, to a method for preparing thereof, and to an antiviral pharmaceutical composition comprising the compound as an active ingredient. The 6-methylpyridine derivatives of the present invention have an excellent inhibitory effect on replication of hepatitis C virus and thus can be advantageously used as a therapeutic or prophylactic agent of hepatitis C

Abstract translation: 本发明涉及可用作抗病毒剂的6-甲基吡啶衍生物。 更具体地说，本发明涉及对丙型肝炎病毒（HCV）的复制或其药学上可接受的盐对其制备方法具有优异抑制作用的新型6-甲基吡啶衍生物，以及含有该化合物的抗病毒药物组合物 作为活性成分。 本发明的6-甲基吡啶衍生物对丙型肝炎病毒的复制具有优异的抑制作用，因此可有利地用作丙型肝炎的治疗或预防药物

公开(公告)号：US20060269609A1

公开(公告)日：2006-11-30

申请号：US10528461

申请日：2003-10-02

Applicant: Jong-Woo Kim ,  Sang-Wook Lee ,  Geun-Hyung Lee ,  Jae-Jin Han ,  Sang-Jin Park ,  Eul-Yong Park ,  Joong-Chul Shin

Inventor： Jong-Woo Kim ,  Sang-Wook Lee ,  Geun-Hyung Lee ,  Jae-Jin Han ,  Sang-Jin Park ,  Eul-Yong Park ,  Joong-Chul Shin

IPC: A61K36/254 ,  A61K36/82 ,  A61K36/16 ,  A61K36/13

CPC classification number: C07D213/80

Abstract: The present invention relates to 6-methylpyridine derivatives useful as an antiviral agent. More particularly, the present invention relates to novel 6-methylpyridine derivatives having an excellent inhibitory effect on replication of Hepatitis C virus (HCV), or pharmaceutically acceptable salts thereof, to a method for preparing thereof, and to an antiviral pharmaceutical composition comprising the compound as an active ingredient. The 6-methylpyridine derivatives of the present invention have an excellent inhibitory effect on replication of hepatitis C virus and thus can be advantageously used as a therapeutic or prophylactic agent of hepatitis C.

Abstract translation: 本发明涉及可用作抗病毒剂的6-甲基吡啶衍生物。 更具体地说，本发明涉及对丙型肝炎病毒（HCV）的复制或其药学上可接受的盐对其制备方法具有优异抑制作用的新型6-甲基吡啶衍生物，以及含有该化合物的抗病毒药物组合物 作为活性成分。 本发明的6-甲基吡啶衍生物对丙型肝炎病毒的复制具有优异的抑制作用，因此可有利地用作丙型肝炎的治疗或预防剂。